Current advances of organocatalytic Michael–Michael cascade reaction in the synthesis of highly functionalized cyclic molecules

Stereoselective synthesis of spirooxindole derivatives using an organocatalyzed tandem Michael–Michael reaction

(2016) Huicai Huang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bifunctional Amine-Squaramides: Powerful Hydrogen-Bonding Organocatalysts for Asymmetric Domino/Cascade Reactions

(2015) Pankaj Chauhan et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric synthesis of pyrazoles and pyrazolones employing the reactivity of pyrazolin-5-one derivatives

(2015) Pankaj Chauhan et al.   CHEMICAL COMMUNICATIONS

Design and Synthesis of (E)-4-(2-Phenyl-2H-chromen-3-yl)but-3-en-2-ones and Evaluation of their In Vitro Antimicrobial Activity

(2015) Sabita Nayak et al.   LETTERS IN ORGANIC CHEMISTRY

Enantioselective cascade double Michael addition of 3-nitro-2H-chromenes and acyclic enones: efficient synthesis of functionalized tricyclic chroman derivatives

(2015) Jun-Hua Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Expanding the Scope of the Organocatalytic Addition of Fluorobis(phenylsulfonyl)methane to Enals: Enantioselective Cascade Synthesis of Fluoroindane and Fluorochromanol Derivatives

(2014) Young Sug Kim et al.   ADVANCED SYNTHESIS & CATALYSIS

Synergistic–cooperative combination of enamine catalysis with transition metal catalysis

(2014) Yongming Deng et al.   CHEMICAL COMMUNICATIONS

Organocatalyzed Cascade Aza-Michael/Michael Addition for the Asymmetric Construction of Highly Functionalized Spiropyrazolone Tetrahydroquinolines

(2014) Jun-Hua Li et al.   Chemistry-An Asian Journal

Regio- and Enantioselective Organocascade Michael-Michael Reactions: Construction of Chiral Trisubstituted Indanes

(2014) Ning Li et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of Aculeatin A via Double Intramolecular Oxa-Michael Addition of Secondary/Tertiary Alcohols

(2014) Hongliang Yao et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Asymmetric Michael–Michael Cascade for the Construction of Highly Functionalized N-Fused Piperidinoindoline Derivatives

(2014) Yong-Long Zhao et al.   ORGANIC LETTERS

An Organocatalytic Michael–Michael Cascade for the Enantioselective Construction of Spirocyclopentane Bioxindoles: Control of Four Contiguous Stereocenters

(2014) Wangsheng Sun et al.   ORGANIC LETTERS

Synthetic application of pipecolic acid

(2014) Seetaram Mohapatra et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies

(2014) Daojuan Cheng et al.   ACS Catalysis

An efficient catalyst free synthesis of nitrogen containing spiro heterocycles via [5 + 1] double Michael addition reaction

(2014) Komal Aggarwal et al.   RSC Advances

Organocatalytic Enantioselective Cascade Aza-Michael/Michael Addition for the Synthesis of Highly Functionalized Tetrahydroquinolines and Tetrahydrochromanoquinolines

(2013) Wen Yang et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis of Optically Enriched Spirocyclic Benzofuran-2-ones by Bifunctional Thiourea-Base Catalyzed Double-Michael Addition of Benzofuran-2-ones to Dienones

(2013) Xin Li et al.   Chemistry-An Asian Journal

Organocatalyzed Michael–Michael Cascade Reaction: Asymmetric Synthesis of Polysubstituted Chromans

(2013) Zhen-Xin Jia et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Synthesis of Trisubstituted Tetrahydrothiophenes Bearing a Quaternary Stereocenter via Double Michael Reaction Involving Dynamic Kinetic Resolution

(2013) Sara Meninno et al.   ORGANIC LETTERS

One-Pot Organocatalytic Enantioselective Domino Double-Michael Reaction and Pictet-Spengler–Lactamization Reaction. A Facile Entry to the “Inside Yohimbane” System with Five Contiguous Stereogenic Centers

(2013) Bor-Cherng Hong et al.   ORGANIC LETTERS

Organocatalytic Domino Reaction of Cyanosulfones: Access to Complex Cyclohexane Systems with Quaternary Carbon Centers

(2013) Sundaram Rajkumar et al.   ORGANIC LETTERS

Organocatalytic oxa/aza-Michael–Michael Cascade Strategy for the Construction of Spiro [Chroman/Tetrahydroquinoline-3,3′-oxindole] Scaffolds

(2013) Haibin Mao et al.   ORGANIC LETTERS

Squaramide–Tertiary Amine Catalyzed Asymmetric Cascade Sulfa-Michael/Michael Addition via Dynamic Kinetic Resolution: Access to Highly Functionalized Chromans with Three Contiguous Stereocenters

(2013) Wen Yang et al.   ORGANIC LETTERS

Asymmetric Domino Double Michael Addition of Nitroolefins and Aldehyde Esters with trans-Perhydroindolic Acid as an Organocatalyst

(2013) Delong Liu et al.   SYNTHESIS-STUTTGART

Expedient synthesis of bicyclo[3.2.1]octanes and bicyclo[3.3.1]nonanes via the double Michael addition to cyclic dienones

(2013) Aurélie Moulia et al.   RSC Advances

Organocatalytic tandem Michael addition reactions: A powerful access to the enantioselective synthesis of functionalized chromenes, thiochromenes and 1,2-dihydroquinolines

(2012) Chittaranjan Bhanja et al.   Beilstein Journal of Organic Chemistry

Organocatalytic Aza-Michael-Michael Cascade Reactions: A Flexible Approach to 2,3,4-Trisubstituted Tetrahydroquinolines

(2012) Zhen-Xin Jia et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Enantioselective Synthesis of Spiro[cyclohexanone-oxindoles] and Spiro[cyclohexanone-pyrazolones] by Asymmetric Cascade [5+1] Double Michael Reactions

(2012) Bin Wu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

An organocatalytic asymmetric double Michael cascade reaction of unsaturated ketones and unsaturated pyrazolones: highly efficient synthesis of spiropyrazolone derivatives

(2012) Jinyan Liang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Diastereo- and enantioselective synthesis of densely functionalized cyclohexanones via double Michael addition of curcumins with nitroalkenes

(2012) Narasimham Ayyagari et al.   TETRAHEDRON-ASYMMETRY

Efficient synthesis of optically active 4-nitro-cyclohexanones via bifunctional thiourea-base catalyzed double-Michael addition of nitromethane to dienones

(2011) Bin Wu et al.   CHEMICAL COMMUNICATIONS

Catalytic Asymmetric Aza-Michael−Michael Addition Cascade: Enantioselective Synthesis of Polysubstituted 4-Aminobenzopyrans

(2011) Xu-Fan Wang et al.   ORGANIC LETTERS

Chiral Counteranion Synergistic Organocatalysis under High Temperature: Efficient Construction of Optically Pure Spiro[cyclohexanone-oxindole] Backbone

(2011) Yu-Bao Lan et al.   ORGANIC LETTERS

Catalytic Asymmetric Construction of Spirocyclopentaneoxindoles by a Combined Ru-Catalyzed Cross-Metathesis/Double Michael Addition Sequence

(2011) Ying-Mei Li et al.   ORGANIC LETTERS

Organocatalytic enantioselective construction of nitrocyclohexanes containing multiple chiral centres via a cascade reaction

(2011) Sundaram Rajkumar et al.   Chemical Science

Recent advances in organocatalytic asymmetric Michael reactions

(2011) Yong Zhang et al.   Catalysis Science & Technology

Organocatalytic Asymmetric Sulfa-Michael/Michael Addition Reactions: A Strategy for the Synthesis of Highly Substituted Chromans with a Quaternary Stereocenter

(2010) Xu-Fan Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iminium-Allenamine Cascade Catalysis: One-Pot Access to Chiral 4H-Chromenes by a Highly Enantioselective Michael-Michael Sequence

(2010) Xinshuai Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic cascade reactions as a new tool in total synthesis

(2010) Christoph Grondal et al.   Nature Chemistry

Enantioselective Synthesis of Polysubstituted Cyclopentanones by Organocatalytic Double Michael Addition Reactions

(2010) Anqi Ma et al.   ORGANIC LETTERS

Asymmetric Organocatalytic Double-Conjugate Addition of Malononitrile to Dienones: Efficient Synthesis of Optically Active Cyclohexanones

(2010) Xue-ming Li et al.   ORGANIC LETTERS

Organocascade Reactions of Enones Catalyzed by a Chiral Primary Amine

(2009) Li-Yuan Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Highly Stereoselective Hydrogen-Bond-Mediated Michael–Michael Cascade Process through Dynamic Kinetic Resolution

(2008) Jian Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery and Application of Asymmetric Reaction by Multi-Functional Thioureas

(2008) Hideto Miyabe et al.   BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

Highly enantio- and diastereoselective organocatalytic cascade aza-Michael–Michael reactions: a direct method for the synthesis of trisubstituted chiral pyrrolidines

(2008) Hao Li et al.   CHEMICAL COMMUNICATIONS

Organocatalytic Double Michael Reaction of 7-Oxohept-2-enoates and Nitrostyrene – Formal Synthesis of (–)-α- and (–)-β-Lycorane

(2008) Bor-Cherng Hong et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The advent and development of organocatalysis

(2008) David W. C. MacMillan   NATURE

Control of Four Stereocenters in an Organocatalytic Domino Double Michael Reaction: Efficient Synthesis of Multisubstituted Cyclopentanes

(2008) Bin Tan et al.   ORGANIC LETTERS