The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells

Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle

(2015) Tiago C. Alves et al.   Cell Metabolism

Hyperglycemia promotes p53-Mdm2 interaction but reduces p53 ubiquitination in RINm5F cells

(2015) Barzalobre-Gerónimo Raúl et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes

(2015) Bengt-Frederik Belgardt et al.   NATURE MEDICINE

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation

(2014) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic  -cell function in diabetes

(2014) A. Hoshino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Endothelial p53 Improves Metabolic Abnormalities Related to Dietary Obesity

(2014) Masataka Yokoyama et al.   Cell Reports

TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt

(2013) Kenneth K. Y. Cheng et al.   BIOCHEMICAL JOURNAL

Metabolic Regulation by p53 Family Members

(2013) Celia R. Berkers et al.   Cell Metabolism

Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in β Cells

(2013) Sharona Tornovsky-Babeay et al.   Cell Metabolism

Global gene expression profiling of pancreatic islets in mice during streptozotocin-induced  -cell damage and pancreatic Glp-1 gene therapy

(2013) J. M. Tonne et al.   Disease Models & Mechanisms

Another fork in the road—life or death decisions by the tumour suppressor p53

(2013) Luis A Carvajal et al.   EMBO REPORTS

Toxicity generated through inhibition of pyruvate carboxylase and carnitine palmitoyl transferase-1 is similar to high glucose/palmitate-induced glucolipotoxicity in INS-1 beta cells

(2013) Ji-Hyun Lee et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Geniposide Regulates Glucose-Stimulated Insulin Secretion Possibly through Controlling Glucose Metabolism in INS-1 Cells

(2013) Jianhui Liu et al.   PLoS One

Regulation of GAD65 expression by SMAR1 and p53 upon Streptozotocin treatment

(2012) Sandeep Singh et al.   BMC MOLECULAR BIOLOGY

p53-Induced Adipose Tissue Inflammation Is Critically Involved in the Development of Insulin Resistance in Heart Failure

(2012) Ippei Shimizu et al.   Cell Metabolism

Rapid and simplified purification of recombinant adeno-associated virus

(2012) Ping Guo et al.   JOURNAL OF VIROLOGICAL METHODS

APPL1 potentiates insulin secretion in pancreatic   cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice

(2012) K. K. Y. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction in pancreatic β cells

(2012) Sachin Supale et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

 40 Isoform of p53 Controls  -Cell Proliferation and Glucose Homeostasis in Mice

(2011) C. Hinault et al.   DIABETES

Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway

(2011) Yuedan Zhou et al.   HUMAN MOLECULAR GENETICS

Inactivation ofarf-bp1Induces p53 Activation and Diabetic Phenotypes in Mice

(2011) Ning Kon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice

(2011) Takahiro Kodama et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamics of insulin secretion and the clinical implications for obesity and diabetes

(2011) Susumu Seino et al.   JOURNAL OF CLINICAL INVESTIGATION

The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism: Going round in circles?

(2011) Mary C. Sugden et al.   Islets

Regulation of insulin secretion: role of mitochondrial signalling

(2010) S. Jitrapakdee et al.   DIABETOLOGIA

Adipocyte Fatty Acid-binding Protein Modulates Inflammatory Responses in Macrophages through a Positive Feedback Loop Involving c-Jun NH2-terminal Kinases and Activator Protein-1

(2010) Xiaoyan Hui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose induces expression of rat pyruvate carboxylase through a carbohydrate response element in the distal gene promoter

(2009) Kim B. Pedersen et al.   BIOCHEMICAL JOURNAL

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

The multiple levels of regulation by p53 ubiquitination

(2009) J T Lee et al.   CELL DEATH AND DIFFERENTIATION

APPL1 Potentiates Insulin-Mediated Inhibition of Hepatic Glucose Production and Alleviates Diabetes via Akt Activation in Mice

(2009) Kenneth K.Y. Cheng et al.   Cell Metabolism

Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes

(2009) M. J. MacDonald et al.   DIABETOLOGIA

Peroxisome proliferator-activated receptor α (PPARα) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism

(2009) F. Frigerio et al.   DIABETOLOGIA

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

The role of pyruvate carboxylase in insulin secretion and proliferation in rat pancreatic beta cells

(2008) J. Xu et al.   DIABETOLOGIA

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY