标题
LSD1: biologic roles and therapeutic targeting
作者
关键词
-
出版物
Epigenomics
Volume 8, Issue 8, Pages 1103-1116
出版商
Future Medicine Ltd
发表日期
2016-08-02
DOI
10.2217/epi-2016-0009
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones
- (2016) Jonathan M. Burg et al. BIOCHEMISTRY
- Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes
- (2016) John P. McGrath et al. CANCER RESEARCH
- The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice
- (2015) S. Cui et al. BLOOD
- A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC
- (2015) Helai P. Mohammad et al. CANCER CELL
- Lysine Demethylase LSD1 Coordinates Glycolytic and Mitochondrial Metabolism in Hepatocellular Carcinoma Cells
- (2015) A. Sakamoto et al. CANCER RESEARCH
- A Systematic Review of Histone Lysine-Specific Demethylase 1 and Its Inhibitors
- (2015) Yi-Chao Zheng et al. MEDICINAL RESEARCH REVIEWS
- A Specific LSD1/KDM1A Isoform Regulates Neuronal Differentiation through H3K9 Demethylation
- (2015) Benoit Laurent et al. MOLECULAR CELL
- GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1
- (2015) Roshana Thambyrajah et al. NATURE CELL BIOLOGY
- Functional annotation of native enhancers with a Cas9–histone demethylase fusion
- (2015) Nicola A Kearns et al. NATURE METHODS
- LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control
- (2015) Jianxun Wang et al. NATURE NEUROSCIENCE
- Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma
- (2015) Melissa M. Singh et al. NEURO-ONCOLOGY
- HMG20A is required for SNAI1-mediated epithelial to mesenchymal transition
- (2015) S Rivero et al. ONCOGENE
- LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2
- (2015) Miki Takeuchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease
- (2015) Tamara Maes et al. Epigenomics
- LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice
- (2015) Jeesun Kim et al. Nature Communications
- Reversible LSD1 Inhibition Interferes with Global EWS/ETS Transcriptional Activity and Impedes Ewing Sarcoma Tumor Growth
- (2014) S. Sankar et al. CLINICAL CANCER RESEARCH
- Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells
- (2014) W Fiskus et al. LEUKEMIA
- Reversible Inhibitors of LSD1 as Therapeutic Agents in Acute Myeloid Leukemia: Clinical Significance and Progress to Date
- (2014) Daniel P. Mould et al. MEDICINAL RESEARCH REVIEWS
- Differential Properties of Transcriptional Complexes Formed by the CoREST Family
- (2014) A. P. Barrios et al. MOLECULAR AND CELLULAR BIOLOGY
- Destabilizing LSD1 by Jade-2 Promotes Neurogenesis: An Antibraking System in Neural Development
- (2014) Xiao Han et al. MOLECULAR CELL
- Phosphorylation of LSD1 by PKCα Is Crucial for Circadian Rhythmicity and Phase Resetting
- (2014) Hye Jin Nam et al. MOLECULAR CELL
- Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation
- (2014) G. Upadhyay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chromatin state dynamics during blood formation
- (2014) D. Lara-Astiaso et al. SCIENCE
- Lysine-Specific Demethylase 1 Has Dual Functions as a Major Regulator of Androgen Receptor Transcriptional Activity
- (2014) Changmeng Cai et al. Cell Reports
- Lsd1 Restricts the Number of Germline Stem Cells by Regulating Multiple Targets in Escort Cells
- (2014) Susan Eliazer et al. PLoS Genetics
- The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines
- (2013) Tracy Murray-Stewart et al. AMINO ACIDS
- Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors
- (2013) J. E. Welcker et al. DEVELOPMENT
- The histone demethylase LSD1/KDM1A promotes the DNA damage response
- (2013) Nima Mosammaparast et al. JOURNAL OF CELL BIOLOGY
- Nonpeptidic Propargylamines as Inhibitors of Lysine Specific Demethylase 1 (LSD1) with Cellular Activity
- (2013) Martin L. Schmitt et al. JOURNAL OF MEDICINAL CHEMISTRY
- Phosphorylation of neuronal Lysine-Specific Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2
- (2013) Emanuela Toffolo et al. JOURNAL OF NEUROCHEMISTRY
- Modification of Enhancer Chromatin: What, How, and Why?
- (2013) Eliezer Calo et al. MOLECULAR CELL
- Locus-specific editing of histone modifications at endogenous enhancers
- (2013) Eric M Mendenhall et al. NATURE BIOTECHNOLOGY
- Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction
- (2013) Lihong Shi et al. NATURE MEDICINE
- Histone lysine demethylases as targets for anticancer therapy
- (2013) Jonas W. Højfeldt et al. NATURE REVIEWS DRUG DISCOVERY
- Development and evaluation of selective, reversible LSD1 inhibitors derived from fragments
- (2013) James R. Hitchin et al. MedChemComm
- Synthesis and Evaluation of Novel Cyclic Peptide Inhibitors of Lysine-Specific Demethylase 1
- (2013) Isuru R. Kumarasinghe et al. ACS Medicinal Chemistry Letters
- Pluripotent Stem Cell Protein Sox2 Confers Sensitivity to LSD1 Inhibition in Cancer Cells
- (2013) Xiaoming Zhang et al. Cell Reports
- The Deubiquitinase USP28 Stabilizes LSD1 and Confers Stem-Cell-like Traits to Breast Cancer Cells
- (2013) Yadi Wu et al. Cell Reports
- Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation
- (2013) Marc A Kerenyi et al. eLife
- The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells
- (2012) William J. Harris et al. CANCER CELL
- Inhibiting Interactions of Lysine Demethylase LSD1 with Snail/Slug Blocks Cancer Cell Invasion
- (2012) G. Ferrari-Amorotti et al. CANCER RESEARCH
- LSD1 inhibition: a therapeutic strategy in cancer?
- (2012) James T Lynch et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Low Molecular Weight Amidoximes that Act as Potent Inhibitors of Lysine-Specific Demethylase 1
- (2012) Stuart Hazeldine et al. JOURNAL OF MEDICINAL CHEMISTRY
- Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation
- (2012) A Sprüssel et al. LEUKEMIA
- LSD2/KDM1B and Its Cofactor NPAC/GLYR1 Endow a Structural and Molecular Model for Regulation of H3K4 Demethylation
- (2012) Rui Fang et al. MOLECULAR CELL
- Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
- (2012) Tino Schenk et al. NATURE MEDICINE
- LSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition
- (2012) R. Baron et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure
- (2012) Shinjiro Hino et al. Nature Communications
- Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties
- (2011) J. Wang et al. CANCER RESEARCH
- CoREST/LSD1 Control the Development of Pyramidal Cortical Neurons
- (2011) Patricio Fuentes et al. CEREBRAL CORTEX
- Pioneer transcription factors: establishing competence for gene expression
- (2011) K. S. Zaret et al. GENES & DEVELOPMENT
- Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A
- (2011) Todd S. Macfarlan et al. GENES & DEVELOPMENT
- LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells
- (2011) Antonio Adamo et al. NATURE CELL BIOLOGY
- miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells
- (2011) GuoQiang Sun et al. Nature Communications
- The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1
- (2010) Yiwei Lin et al. EMBO JOURNAL
- Alternative Splicing of the Histone Demethylase LSD1/KDM1 Contributes to the Modulation of Neurite Morphogenesis in the Mammalian Nervous System
- (2010) C. Zibetti et al. JOURNAL OF NEUROSCIENCE
- Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases LSD1 and LSD2
- (2010) Claudia Binda et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Histone Demethylase LSD1 Regulates Neural Stem Cell Proliferation
- (2010) G. Sun et al. MOLECULAR AND CELLULAR BIOLOGY
- Lysine-Specific Demethylase 1 Regulates the Embryonic Transcriptome and CoREST Stability
- (2010) C. T. Foster et al. MOLECULAR AND CELLULAR BIOLOGY
- Lysine Methylation Regulates E2F1-Induced Cell Death
- (2010) Haroula Kontaki et al. MOLECULAR CELL
- Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition
- (2010) T Lin et al. ONCOGENE
- Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
- (2010) M.-C. Tsai et al. SCIENCE
- Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy
- (2009) J. H. Schulte et al. CANCER RESEARCH
- Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology
- (2009) Soyoung Lim et al. CARCINOGENESIS
- LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer
- (2009) Yan Wang et al. CELL
- A C. elegans LSD1 Demethylase Contributes to Germline Immortality by Reprogramming Epigenetic Memory
- (2009) David J. Katz et al. CELL
- Involvement of Histone Demethylase LSD1 in Blimp-1-Mediated Gene Repression during Plasma Cell Differentiation
- (2009) S.-T. Su et al. MOLECULAR AND CELLULAR BIOLOGY
- Direct Binding of CoREST1 to SUMO-2/3 Contributes to Gene-Specific Repression by the LSD1/CoREST1/HDAC Complex
- (2009) Jian Ouyang et al. MOLECULAR CELL
- Inhibition of the histone demethylase LSD1 blocks α-herpesvirus lytic replication and reactivation from latency
- (2009) Yu Liang et al. NATURE MEDICINE
- LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
- (2009) X. Hu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
- (2008) Jing Wang et al. NATURE GENETICS
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