期刊
EPIGENOMICS
卷 7, 期 4, 页码 609-626出版社
FUTURE MEDICINE LTD
DOI: 10.2217/EPI.15.9
关键词
acute myeloid leukemia; ORY-1001; Alzheimer's disease; ORY-2001; SCLC; GSK2879552; histone lysine demethylases KDMs; Huntington's disease; oncology
资金
- Marie Curie Initial Training Network FP7-PEOPLE-ITN [PITN-GA-289880]
- Cancer Research UK [C5759/A12328]
- Cancer Research UK [19280] Funding Source: researchfish
Histone methylation and demethylation are important processes associated with the regulation of gene transcription, and alterations in histone methylation status have been linked to a large number of human diseases. Initially thought to be an irreversible process, histone methylation is now known to be reversed by two families of proteins containing over 30 members that act to remove methyl groups from specific lysine residues present in the tails of histone H3 and histone H4. A rapidly growing number of reports have implicated the FAD-dependent lysine specific demethylase (KDM1) family in cancer, and several small-molecule inhibitors are in development for the treatment of cancer. An additional role has emerged for KDM1 in brain function, offering additional opportunities for the development of novel therapeutic strategies in neurodegenerative disease. A decade after the identification of KDM1A as a histone demethylase, the first selective inhibitors have now reached the clinic.
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