GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1

Distinct Sources of Hematopoietic Progenitors Emerge before HSCs and Provide Functional Blood Cells in the Mammalian Embryo

(2015) Kathleen E. McGrath et al.   Cell Reports

In Vivo Repopulating Activity Emerges at the Onset of Hematopoietic Specification during Embryonic Stem Cell Differentiation

(2015) Stella Pearson et al.   Stem Cell Reports

RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence

(2014) M. Lie-A-Ling et al.   BLOOD

Gfi-1 regulates the erythroid transcription factor network through Id2 repression in murine hematopoietic progenitor cells

(2014) W. Kim et al.   BLOOD

Progressive maturation toward hematopoietic stem cells in the mouse embryo aorta

(2014) J.-C. Boisset et al.   BLOOD

Reprogramming human endothelial cells to haematopoietic cells requires vascular induction

(2014) Vladislav M. Sandler et al.   NATURE

Direct Reprogramming of Murine Fibroblasts to Hematopoietic Progenitor Cells

(2014) Kiran Batta et al.   Cell Reports

Erythro-myeloid progenitors: “Definitive” hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells

(2013) Jenna M. Frame et al.   BLOOD CELLS MOLECULES AND DISEASES

Induction of a Hemogenic Program in Mouse Fibroblasts

(2013) Carlos-Filipe Pereira et al.   Cell Stem Cell

Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis

(2013) Victoria Moignard et al.   NATURE CELL BIOLOGY

The expression of Sox17 identifies and regulates haemogenic endothelium

(2013) Raedun L. Clarke et al.   NATURE CELL BIOLOGY

Smooth muscle cells largely develop independently of functional hemogenic endothelium

(2013) Monika Stefanska et al.   Stem Cell Research

Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level

(2013) Gemma Swiers et al.   Nature Communications

GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment

(2012) C. Lancrin et al.   BLOOD

The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells

(2012) William J. Harris et al.   CANCER CELL

SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development

(2012) G. Costa et al.   DEVELOPMENT

RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis

(2012) Monika Lichtinger et al.   EMBO JOURNAL

Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling

(2012) Jordi Guiu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Origin of blood cells and HSC production in the embryo

(2012) Guilherme Costa et al.   TRENDS IN IMMUNOLOGY

Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region

(2011) Stanislav Rybtsov et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Growth factor independence 1 (Gfi1) as a regulator of lymphocyte development and activation

(2011) Tarik Möröy et al.   SEMINARS IN IMMUNOLOGY

Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells

(2010) E. Y. N. Lam et al.   BLOOD

Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos

(2010) T. Yokomizo et al.   DEVELOPMENT

The Notch pathway in the developing hematopoietic system

(2010) Anna Bigas et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Gfi1 Expression Is Controlled by Five Distinct Regulatory Regions Spread over 100 Kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 Acting as Upstream Regulators in Early Hematopoietic Cells

(2010) N. K. Wilson et al.   MOLECULAR AND CELLULAR BIOLOGY

Lysine-Specific Demethylase 1 Regulates the Embryonic Transcriptome and CoREST Stability

(2010) C. T. Foster et al.   MOLECULAR AND CELLULAR BIOLOGY

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium

(2010) Jean-Charles Boisset et al.   NATURE

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

(2010) Karima Kissa et al.   NATURE

Haematopoietic stem cells derive directly from aortic endothelium during development

(2010) Julien Y. Bertrand et al.   NATURE

The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis

(2009) P. Sroczynska et al.   BLOOD

Blood cell generation from the hemangioblast

(2009) Christophe Lancrin et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

(2009) Michael J. Chen et al.   NATURE

Continuous single-cell imaging of blood generation from haemogenic endothelium

(2009) Hanna M. Eilken et al.   NATURE

The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage

(2009) Christophe Lancrin et al.   NATURE

Validated germline-competent embryonic stem cell lines from nonobese diabetic mice

(2009) Jennifer Nichols et al.   NATURE MEDICINE

Extensive Hematopoietic Stem Cell Generation in the AGM Region via Maturation of VE-Cadherin+CD45+ Pre-Definitive HSCs

(2008) Samir Taoudi et al.   Cell Stem Cell

Fate Tracing Reveals the Endothelial Origin of Hematopoietic Stem Cells

(2008) Ann C. Zovein et al.   Cell Stem Cell

Efficient Hematopoietic Differentiation of Human Embryonic Stem Cells on Stromal Cells Derived from Hematopoietic Niches

(2008) Maria H. Ledran et al.   Cell Stem Cell

Regulation of vascular permeability by sphingosine 1-phosphate

(2008) Lichun Wang et al.   MICROVASCULAR RESEARCH

The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

(2008) Jing Wang et al.   NATURE GENETICS