Insights into APC/C: from cellular function to diseases and therapeutics

Choose Delicately and Reuse Adequately: The Newly Revealed Process of Autophagy

(2015) Satoru Kobayashi   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Phosphorylation-dependent degradation of MEF2C contributes to regulate G2/M transition

(2015) Sara Badodi et al.   CELL CYCLE

Controlling the response to DNA damage by the APC/C-Cdh1

(2015) H. Rudolf de Boer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cyclin B3 Is a Mitotic Cyclin that Promotes the Metaphase-Anaphase Transition

(2015) Kai Yuan et al.   CURRENT BIOLOGY

Bub3–BubR1-dependent sequestration of Cdc20 Fizzy at DNA breaks facilitates the correct segregation of broken chromosomes

(2015) Nicolas Derive et al.   JOURNAL OF CELL BIOLOGY

Bub3 promotes Cdc20-dependent activation of the APC/C inS. cerevisiae

(2015) Yang Yang et al.   JOURNAL OF CELL BIOLOGY

Nek2A destruction marks APC/C activation at the prophase-to-prometaphase transition by spindle-checkpoint-restricted Cdc20

(2015) M. Boekhout et al.   JOURNAL OF CELL SCIENCE

Timely Degradation of Wip1 Phosphatase by APC/C Activator Protein Cdh1 is Necessary for Normal Mitotic Progression

(2015) Ho-Chang Jeong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain

(2015) Nora B. Cronin et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of an APC3–APC16 Complex: Insights into Assembly of the Anaphase-Promoting Complex/Cyclosome

(2015) Masaya Yamaguchi et al.   JOURNAL OF MOLECULAR BIOLOGY

Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages

(2015) Mingwei Min et al.   MOLECULAR BIOLOGY OF THE CELL

The Ubp15 deubiquitinase promotes timely entry into S phase in Saccharomyces cerevisiae

(2015) Denis Ostapenko et al.   MOLECULAR BIOLOGY OF THE CELL

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1

(2015) Seung Baek Lee et al.   MOLECULAR CELL

Atomic structure of the APC/C and its mechanism of protein ubiquitination

(2015) Leifu Chang et al.   NATURE

Spatiotemporal regulation of the anaphase-promoting complex in mitosis

(2015) Sushama Sivakumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Cdh1-APC/FMRP Ubiquitin Signaling Link Drives mGluR-Dependent Synaptic Plasticity in the Mammalian Brain

(2015) Ju Huang et al.   NEURON

Deubiquitinase inhibition as a cancer therapeutic strategy

(2015) Padraig D'Arcy et al.   PHARMACOLOGY & THERAPEUTICS

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

(2015) Nicholas G. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of autophagy induced by PTEN loss promotes intrinsic breast cancer resistance to trastuzumab therapy

(2015) Liao Ning et al.   TUMOR BIOLOGY

Degradation of Ndd1 by APC/CCdh1 generates a feed forward loop that times mitotic protein accumulation

(2015) Julia Sajman et al.   Nature Communications

CDC20 maintains tumor initiating cells

(2015) Qi Xie et al.   Oncotarget

A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells

(2015) Diane D. Mao et al.   Cell Reports

Casein Kinase 1δ Is an APC/CCdh1 Substrate that Regulates Cerebellar Granule Cell Neurogenesis

(2015) Clara Penas et al.   Cell Reports

Regulation of mRNA translation during mitosis

(2015) Marvin E Tanenbaum et al.   eLife

MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C

(2015) E. Voets et al.   Biology Open

Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1

(2015) Zhenghong Lin et al.   Cell Discovery

LATS1 and LATS2 Phosphorylate CDC26 to Modulate Assembly of the Tetratricopeptide Repeat Subcomplex of APC/C

(2015) Kenta Masuda et al.   PLoS One

Loss of Pten, a tumor suppressor, causes the strong inhibition of autophagy without affecting LC3 lipidation

(2014) Takashi Ueno et al.   Autophagy

Cyclin A/Cdk2 regulates Cdh1 and claspin during late S/G2 phase of the cell cycle

(2014) Vanessa Oakes et al.   CELL CYCLE

A novel Fizzy/Cdc20-dependent mechanism suppresses necrosis in neural stem cells

(2014) C. Kuang et al.   DEVELOPMENT

APCCdc20 Suppresses Apoptosis through Targeting Bim for Ubiquitination and Destruction

(2014) Lixin Wan et al.   DEVELOPMENTAL CELL

APC/CCdh1controls CtIP stability during the cell cycle and in response to DNA damage

(2014) Lorenzo Lafranchi et al.   EMBO JOURNAL

Cdh1, a Substrate-recruiting Component of Anaphase-promoting Complex/Cyclosome (APC/C) Ubiquitin E3 Ligase, Specifically Interacts with Phosphatase and Tensin Homolog (PTEN) and Promotes Its Removal from Chromatin

(2014) Byeong Hyeok Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plk1 Protein Phosphorylates Phosphatase and Tensin Homolog (PTEN) and Regulates Its Mitotic Activity during the Cell Cycle

(2014) Byeong Hyeok Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II

(2014) Deepak Adhikari et al.   JOURNAL OF CELL BIOLOGY

Glucose and glutamine metabolism control by APC and SCF during the G1-to-S phase transition of the cell cycle

(2014) Irving Omar Estévez-García et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Necessary and Sufficient Role for a Mitosis Skip in Senescence Induction

(2014) Yoshikazu Johmura et al.   MOLECULAR CELL

Ubiquitin Chain Elongation Requires E3-Dependent Tracking of the Emerging Conjugate

(2014) Aileen Kelly et al.   MOLECULAR CELL

Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly

(2014) Nicholas G. Brown et al.   MOLECULAR CELL

The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C

(2014) Daisuke Izawa et al.   NATURE

Molecular architecture and mechanism of the anaphase-promoting complex

(2014) Leifu Chang et al.   NATURE

Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C

(2014) Katharine L. Sackton et al.   NATURE

SCF ubiquitin ligase-targeted therapies

(2014) Jeffrey R. Skaar et al.   NATURE REVIEWS DRUG DISCOVERY

Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling

(2014) Joo Seok Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Synthetic Lethal Interaction between APC/C and Topoisomerase Poisons Uncovered by Proteomic Screens

(2014) Manuel Eguren et al.   Cell Reports

The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation

(2014) Shisako Shoji et al.   FEBS Open Bio

Autophagy-dependent ATP release from dying cells via lysosomal exocytosis

(2013) Yidan Wang et al.   Autophagy

Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition

(2013) Anna Budina-Kolomets et al.   CANCER BIOLOGY & THERAPY

The Cell-Cycle State of Stem Cells Determines Cell Fate Propensity

(2013) Siim Pauklin et al.   CELL

Targeting mitotic exit with hyperthermia or APC/C inhibition to increase paclitaxel efficacy

(2013) Serena Giovinazzi et al.   CELL CYCLE

Autophagy regulation by nutrient signaling

(2013) Ryan C Russell et al.   CELL RESEARCH

Regulation of Rad17 Protein Turnover Unveils an Impact of Rad17-APC Cascade in Breast Carcinogenesis and Treatment

(2013) Zhuan Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A tumor suppressor role of the Bub3 spindle checkpoint protein after apoptosis inhibition

(2013) Sara Morais da Silva et al.   JOURNAL OF CELL BIOLOGY

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

(2013) Zhen Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CDC20 overexpression predicts a poor prognosis for patients with colorectal cancer

(2013) Wen-jing Wu et al.   Journal of Translational Medicine

Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex

(2013) Weiping Wang et al.   NATURE CELL BIOLOGY

Mechanisms and function of substrate recruitment by F-box proteins

(2013) Jeffrey R. Skaar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown

(2013) Jeremiah J Frye et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Brain energy metabolism in glutamate-receptor activation and excitotoxicity: Role for APC/C-Cdh1 in the balance glycolysis/pentose phosphate pathway

(2013) Patricia Rodriguez-Rodriguez et al.   NEUROCHEMISTRY INTERNATIONAL

The Molecular Chaperone Hsp90 Is Required for Cell Cycle Exit in Drosophila melanogaster

(2013) Jennifer L. Bandura et al.   PLoS Genetics

The Ubiquitin System, an Immense Realm

(2012) Alexander Varshavsky   Annual Review of Biochemistry

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Recombinant expression, reconstitution and structure of human anaphase-promoting complex (APC/C)

(2012) Ziguo Zhang et al.   BIOCHEMICAL JOURNAL

Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair

(2012) Vincenzo D'Angiolella et al.   CELL

Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

(2012) Isabel Garcia-Cao et al.   CELL

Skp1-Cul1-F-box Ubiquitin Ligase (SCFβTrCP)-mediated Destruction of the Ubiquitin-specific Protease USP37 during G2-phase Promotes Mitotic Entry

(2012) Amy C. Burrows et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1

(2012) Nai-Jia Huang et al.   JOURNAL OF CELL BIOLOGY

HECT and RING finger families of E3 ubiquitin ligases at a glance

(2012) M. B. Metzger et al.   JOURNAL OF CELL SCIENCE

Overexpression of CDC20 predicts poor prognosis in primary non-small cell lung cancer patients

(2012) Tatsuya Kato et al.   JOURNAL OF SURGICAL ONCOLOGY

The Phosphatase-Transcription Activator EYA1 Is Targeted by Anaphase-Promoting Complex/Cdh1 for Degradation at M-to-G1 Transition

(2012) J. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Degradation of Human RAP80 is Cell Cycle Regulated by Cdc20 and Cdh1 Ubiquitin Ligases

(2012) H. J. Cho et al.   MOLECULAR CANCER RESEARCH

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

(2012) Darren J. Baker et al.   NATURE CELL BIOLOGY

An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination

(2012) Xing Zeng et al.   Nature Chemical Biology

DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase

(2012) F. Dotiwala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

(2011) Hyun-Seok Kim et al.   CANCER CELL

FoxM1 is degraded at mitotic exit in a Cdh1-dependent manner

(2011) Jamila Laoukili et al.   CELL CYCLE

Geminin Escapes Degradation in G1 of Mouse Pluripotent Cells and Mediates the Expression of Oct4, Sox2, and Nanog

(2011) Valerie S. Yang et al.   CURRENT BIOLOGY

APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage

(2011) Xiomaris M. Cotto-Rios et al.   JOURNAL OF CELL BIOLOGY

Tango between Ubiquitin Ligase and Deubiquitinase Keeps Cyclin A Tag Free

(2011) Hongtao Yu   MOLECULAR CELL

Deubiquitinase USP37 Is Activated by CDK2 to Antagonize APCCDH1 and Promote S Phase Entry

(2011) XiaoDong Huang et al.   MOLECULAR CELL

DNA Damage Signaling Triggers Degradation of Histone Methyltransferases through APC/CCdh1 in Senescent Cells

(2011) Akiko Takahashi et al.   MOLECULAR CELL

Cubism and the cell cycle: the many faces of the APC/C

(2011) Jonathon Pines   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Constructing and decoding unconventional ubiquitin chains

(2011) Christian Behrends et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Spindle assembly checkpoint: the third decade

(2011) A. Musacchio   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Cell cycle adaptations of embryonic stem cells

(2011) A. Ballabeni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis for the differential use of glucose and glutamine in cell proliferation as revealed by synchronized HeLa cells

(2011) S. L. Colombo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacologic Inhibition of the Anaphase-Promoting Complex Induces A Spindle Checkpoint-Dependent Mitotic Arrest in the Absence of Spindle Damage

(2010) Xing Zeng et al.   CANCER CELL

Targeting Mitotic Exit Leads to Tumor Regression In Vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ Phosphatase

(2010) Eusebio Manchado et al.   CANCER CELL

What Determines the Specificity and Outcomes of Ubiquitin Signaling?

(2010) Fumiyo Ikeda et al.   CELL

Regulation of APC/CCdh1ubiquitin ligase in differentiation of human embryonic stem cells

(2010) Ortal Bar-On et al.   CELL CYCLE

Anaphase-promoting complex/cyclosome controls HEC1 stability

(2010) L. Li et al.   CELL PROLIFERATION

Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress

(2010) Liyong Zhang et al.   EMBO JOURNAL

Phosphorylation of Mcl-1 by CDK1–cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest

(2010) Margaret E Harley et al.   EMBO JOURNAL

Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair

(2010) Annamaria Mocciaro et al.   JOURNAL OF CELL BIOLOGY

Anaphase-Promoting Complex/Cyclosome Participates in the Acute Response to Protein-Damaging Stress

(2010) J. K. Ahlskog et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulated Degradation of Spindle Assembly Factors by the Anaphase-Promoting Complex

(2010) Ling Song et al.   MOLECULAR CELL

K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody

(2010) Marissa L. Matsumoto et al.   MOLECULAR CELL

Catalysis of Lysine 48-Specific Ubiquitin Chain Assembly by Residues in E2 and Ubiquitin

(2010) Monica C. Rodrigo-Brenni et al.   MOLECULAR CELL

Interplay between Cdh1 and JNK activity during the cell cycle

(2010) Gustavo J. Gutierrez et al.   NATURE CELL BIOLOGY

APCCdh1 mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity

(2010) Amy K Y Fu et al.   NATURE NEUROSCIENCE

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

p53- and p21-dependent premature APC/C–Cdh1 activation in G2 is part of the long-term response to genotoxic stress

(2010) L Wiebusch et al.   ONCOGENE

ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint

(2010) S. Miniowitz-Shemtov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Evidence that Mitotic Exit Is a Better Cancer Therapeutic Target Than Spindle Assembly

(2009) Hsiao-Chun Huang et al.   CANCER CELL

A Centrosomal Cdc20-APC Pathway Controls Dendrite Morphogenesis in Postmitotic Neurons

(2009) Albert H. Kim et al.   CELL

Dissecting the role of ubiquitylation in the DNA damage response checkpoint in G2

(2009) F Bassermann et al.   CELL DEATH AND DIFFERENTIATION

Cdh1 Regulates Cell Cycle through Modulating the Claspin/Chk1 and the Rb/E2F1 Pathways

(2009) Daming Gao et al.   MOLECULAR BIOLOGY OF THE CELL

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation

(2009) A. Almeida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a physiological E2 module for the human anaphase-promoting complex

(2009) A. Williamson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Cdc20-APC Ubiquitin Signaling Pathway Regulates Presynaptic Differentiation

(2009) Y. Yang et al.   SCIENCE

Regulation of Skp2-p27 Axis by the Cdh1/Anaphase-Promoting Complex Pathway in Colorectal Tumorigenesis

(2008) Takeo Fujita et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of APC/C Activators in Mitosis and Meiosis

(2008) Jillian A. Pesin et al.   Annual Review of Cell and Developmental Biology

The Cdc14B-Cdh1-Plk1 Axis Controls the G2 DNA-Damage-Response Checkpoint

(2008) Florian Bassermann et al.   CELL

Mechanism of Ubiquitin-Chain Formation by the Human Anaphase-Promoting Complex

(2008) Lingyan Jin et al.   CELL

Control of autophagy by oncogenes and tumor suppressor genes

(2008) M C Maiuri et al.   CELL DEATH AND DIFFERENTIATION

Dissection of the APCCdh1-Skp2 Cascade in Breast Cancer

(2008) T. Fujita et al.   CLINICAL CANCER RESEARCH

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS

TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process

(2008) San San Lee et al.   EXPERIMENTAL CELL RESEARCH

Anaphase-Promoting Complex/Cyclosome-Cdh1-Mediated Proteolysis of the Forkhead Box M1 Transcription Factor Is Critical for Regulated Entry into S Phase

(2008) H. J. Park et al.   MOLECULAR AND CELLULAR BIOLOGY

Genomic stability and tumour suppression by the APC/C cofactor Cdh1

(2008) Irene García-Higuera et al.   NATURE CELL BIOLOGY

The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory

(2008) Min Li et al.   NATURE CELL BIOLOGY