Review
Cell Biology
Flaminia Kaluthantrige Don, Nereo Kalebic
Summary: The expansion of the cerebral cortex is closely related to the acquisition of higher intellectual abilities that distinguish humans from their closest relatives. Recent studies using brain organoids have provided valuable insights into the molecular and cell biological features of basal radial glia (bRG), which can help understand the onset of neurodevelopmental disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Misaal Patel, Jeremy Anderson, Shunyao Lei, Zachary Finkel, Brianna Rodriguez, Fatima Esteban, Rebecca Risman, Ying Li, Ki-Bum Lee, Yi Lisa Lyu, Li Cai
Summary: Nkx6.1 expression in the adult injured spinal cord promotes cell proliferation and activation of endogenous neural stem/progenitor cells, leading to increased interneuron number, reduced reactive astrocytes, minimized glial scar formation, and repressed neuroinflammation. Transcriptomic analysis reveals upregulation of genes involved in cell proliferation, neural differentiation, and Notch signaling pathway, as well as downregulation of genes and pathways related to neuroinflammation, astrocyte activation, and glial scar formation. It supports the potential role of Nkx6.1 in neural regeneration in the adult injured spinal cord.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Cell & Tissue Engineering
Micheli Mainardi Pillat, Ana Carolina Ayupe, Guilherme Juvenal, Carine Meinerz, Talita Glaser, Diogo Vieira da Silva Pellegrina, Daisylea Souza Paiva, Carlos Fernando Mello, Beatriz Monteiro Longo, Eduardo Moraes Reis, Henning Ulrich
Summary: Proteins involved in AD, such as APP and PS1, have a critical role in CNS development and immune response. Mutations in these proteins lead to abnormal expression in NPCs and resemble the brain pathology in adult AD patients.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Neurosciences
Zhen-Hong Yang, Si-Jia Zhang, Hai-Ping Zhao, Fang-Fang Li, Zhen Tao, Yu-Min Luo, Rong-Liang Wang
Summary: This study investigated the effects of erythropoietin (EPO) on the differentiation of neural stem cells (NSCs)/neural progenitors (NPs) in hypoxic-ischemic injury. Results showed that EPO promoted the differentiation of NSCs/NPs into oligodendrocytes and astrocytes, while inhibiting neuronal differentiation. The EPO receptor/β common receptor heterodimer was found to be present on the surface of fetal NSCs/NPs and involved in glial differentiation. The study provides insights into the potential mechanisms of EPO in treating hypoxic-ischemic injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Tyler J. Dause, Jiyeon K. Denninger, Bryon M. Smith, Elizabeth D. Kirby
Summary: This review focuses on investigating the autocrine and paracrine functions of the endogenous NSC secretome across life. Evidence shows that the NSC secretome is critical for how endogenous NSCs regulate themselves and their niche, but there are gaps in current literature, particularly in the clinically-relevant domain of endogenous NSC paracrine function in the injured CNS.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biology
Emanuel Cura Costa, Leo Otsuki, Aida Rodrigo Albors, Elly M. Tanaka, Osvaldo Chara
Summary: Through a combination of modeling and experimental data, it was found that the regenerative response in Axolotls is associated with a specific signal that guides ependymal cell proliferation around the injury site; visualization of cell cycles using FUCCI technology revealed synchrony between cells, contributing to a better understanding of spinal cord regeneration.
Article
Biotechnology & Applied Microbiology
Hunter N. Bomba, Kevin T. Sheets, Alain Valdivia, Simon Khagi, Laura Ruterbories, Christopher L. Mariani, Luke B. Borst, Debra A. Tokarz, Shawn D. Hingtgen
Summary: This study represents a critical step towards clinical translation by generating the first personalized canine iNSCs, exploring their scale-up, persistence, and safety in autologous canine surgery models. The engineered iNSCs showed promising results in targeting and treating aggressive brain cancers, setting the stage for potential human patient testing in the future.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Review
Cell Biology
Tanner Clifford, Zachary Finkel, Brianna Rodriguez, Adelina Joseph, Li Cai
Summary: Spinal cord injury (SCI) leads to permanent and degenerating damage to the central nervous system (CNS). The formation of glial scar plays a role in segregating neural lesion and protecting surrounding healthy tissue, but it also inhibits regeneration. Therapeutic strategies have been developed to overcome the negative effects, including scar prevention, scar resolution, cell transplantation, and cell reprogramming. This review focuses on the molecular and cellular aspects of glial scar formation and discusses the advantages and disadvantages of different regeneration-promoting strategies after SCI.
Article
Cell Biology
Junchen Chen, Xiaoxue Dong, Xuejun Cheng, Qiang Zhu, Jinyu Zhang, Qian Li, Xiaoli Huang, Min Wang, Liping Li, Weixiang Guo, Binggui Sun, Qiang Shu, Wen Yi, Xuekun Li
Summary: Ogt deficiency in adult neural stem/progenitor cells leads to a decrease in the aNSPC pool, abnormal neurogenesis, and impaired cognitive function in adult mice. Mechanistic studies reveal that Ogt catalyzes the O-GlcNAc modification of the Notch TM/ICD fragment, which in turn affects neurogenic defects induced by Ogt deficiency.
Review
Cell & Tissue Engineering
Zijing Zhou, Ben Shi, Yaxing Xu, Jinyu Zhang, Xin Liu, Xinghong Zhou, Baofeng Feng, Jun Ma, Huixian Cui
Summary: This study evaluated the effectiveness of neural stem/progenitor cell (NSPC) therapy in rodent models of Alzheimer's disease (AD). The results showed that NSPC therapy significantly improved cognitive function and reduced pathological features (Aβ deposition and phosphorylated tau levels). Additionally, nanoformulation and genetic modification enhanced the effects of NSPC therapy. Further animal trials and clinical trials are needed to validate the efficacy of this treatment.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Neurosciences
Xiaosu Li, Guoping Liu, Lin Yang, Zhenmeiyu Li, Zhuangzhi Zhang, Zhejun Xu, Yuqun Cai, Heng Du, Zihao Su, Ziwu Wang, Yangyang Duan, Haotian Chen, Zicong Shang, Yan You, Qi Zhang, Miao He, Bin Chen, Zhengang Yang
Summary: The study elucidates the development of mouse cortical radial glial cells into intermediate progenitors and different subtypes of neural cells. It provides insights into the genetic logic underlying the specification and differentiation of cortical glial cells and OB interneurons.
NEUROSCIENCE BULLETIN
(2021)
Article
Cell Biology
Huimin Zhao, Jie Wei, Yanan Du, Peipei Chen, Xiaoquan Liu, Haochen Liu
Summary: Alzheimer's disease (AD) is an age-related neurological dysfunction and current treatments have limited clinical benefits. A study showed that DMP1 can induce cell-cycle arrest in neural progenitor cells and may affect cognitive function in Alzheimer-like mice. Silencing DMP1 increased the number of neural progenitor cells and improved cognitive function in Alzheimer-like mice.
Review
Biochemistry & Molecular Biology
JamesD Melrose
Summary: This study aimed to explore the recent developments in neural repair by using hyaluronan as a carrier of olfactory bulb stem cells and new bioscaffolds. Hyaluronan interacts with hyalectan proteoglycans in the brain to protect neurons and promote synaptic plasticity. Special stem cell niches called fractones migrate to the olfactory bulb from the dentate gyrus of the hippocampus, and these niches contain hyaluronan, perlecan, and laminin alpha 5, which regulate the activity of stem cells and aid in their participation in neural repair processes. Significant improvement in spinal cord injury and brain trauma repair has been achieved using this approach, and further advancements are expected with the use of recombinant perlecan domain I and domain V.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell & Tissue Engineering
Yifeng Zheng, Jun Zhou, Yisai Wang, Fanfan Fan, Shengwen Liu, Yu Wang
Summary: A meta-analysis of studies on rodent animal models of Parkinson's disease (PD) found that unmodified neural stem/progenitor cells (NSPCs) therapy can attenuate behavioral deficits and increase dopaminergic neurons, supporting the consideration of early-stage clinical trials of NSPCs in PD patients.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Lei Han, Xiaoyu Wei, Chuanyu Liu, Giacomo Volpe, Zhenkun Zhuang, Xuanxuan Zou, Zhifeng Wang, Taotao Pan, Yue Yuan, Xiao Zhang, Peng Fan, Pengcheng Guo, Yiwei Lai, Ying Lei, Xingyuan Liu, Feng Yu, Shuncheng Shangguan, Guangyao Lai, Qiuting Deng, Ya Liu, Liang Wu, Quan Shi, Hao Yu, Yunting Huang, Mengnan Cheng, Jiangshan Xu, Yang Liu, Mingyue Wang, Chunqing Wang, Yuanhang Zhang, Duo Xie, Yunzhi Yang, Yeya Yu, Huiwen Zheng, Yanrong Wei, Fubaoqian Huang, Junjie Lei, Waidong Huang, Zhiyong Zhu, Haorong Lu, Bo Wang, Xiaofeng Wei, Fengzhen Chen, Tao Yang, Wensi Du, Jing Chen, Shibo Xu, Juan An, Carl Ward, Zongren Wang, Zhong Pei, Chi-Wai Wong, Xiaolei Liu, Huafeng Zhang, Mingyuan Liu, Baoming Qin, Axel Schambach, Joan Isern, Liqiang Feng, Yan Liu, Xiangyu Guo, Zhen Liu, Qiang Sun, Patrick H. Maxwell, Nick Barker, Pura Munoz-Canoves, Ying Gu, Jan Mulder, Mathias Uhlen, Tao Tan, Shiping Liu, Huanming Yang, Jian Wang, Yong Hou, Xun Xu, Miguel A. Esteban, Longqi Liu
Summary: Studying tissue composition and function in non-human primates is crucial for understanding the nature of human species. This study presents a large-scale cell transcriptomic atlas of the non-human primate Macaca fascicularis, providing a vast annotated resource for studying a species closely related to humans. The atlas has been used to reconstruct cell-cell interaction networks, map the distribution of receptors for viruses causing human infectious diseases, and establish potential clinical associations with human genetic diseases.
Review
Cell & Tissue Engineering
M. Joana Osorio, David H. Rowitch, Paul Tesar, Marius Wernig, Martha S. Windrem, Steven A. Goldman
Editorial Material
Medicine, Research & Experimental
Steven A. Goldman
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Editorial Material
Biochemistry & Molecular Biology
Steven A. Goldman
Review
Cell & Tissue Engineering
Roger A. Barker, Melissa K. Carpenter, Stuart Forbes, Steven A. Goldman, Catriona Jamieson, Charles E. Murry, Jun Takahashi, Gordon Weir
Article
Cell & Tissue Engineering
Mikhail Osipovitch, Andrea Asenjo Martinez, John N. Mariani, Adam Cornwell, Simrat Dhaliwal, Lisa Zou, Devin Chandler-Militello, Su Wang, Xiaojie Li, Sarah-Jehanne Benraiss, Robert Agate, Andrea Lampp, Abdellatif Benraiss, Martha S. Windrem, Steven A. Goldman
Article
Cell Biology
Zhengshan Liu, Mikhail Osipovitch, Abdellatif Benraiss, Nguyen P. T. Huynh, Rossana Foti, Janna Bates, Devin Chandler-Militello, Robert L. Findling, Paul J. Tesar, Maiken Nedergaard, Martha S. Windrem, Steven A. Goldman
Review
Multidisciplinary Sciences
Steven A. Goldman
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2020)
Review
Multidisciplinary Sciences
Maiken Nedergaard, Steven A. Goldman
Article
Computer Science, Artificial Intelligence
Hans J. T. Stephensen, Anne Marie Svane, Carlos B. Villanueva, Steven A. Goldman, Jon Sporring
Summary: The paper introduces a theory on geometrical interaction between biological objects, describing the relation between a reference and an observed object, and defining measures on their intersections. These measures reveal further details about the shape of individual objects and their pairwise geometrical relation.
JOURNAL OF MATHEMATICAL IMAGING AND VISION
(2021)
Article
Neurosciences
Maria Joana Osorio, John N. Mariani, Lisa Zou, Steven J. Schanz, Kate Heffernan, Adam Cornwell, Steven A. Goldman
Summary: Genomic analyses reveal heterogeneity among glial progenitor cells (GPCs) in human grey and white brain matter, with distinct architecture and associated gene expression. White matter GPCs show lower expression of genes associated with astrocytic fate and have simpler morphology compared to grey matter GPCs. Human grey matter GPCs exhibit more complex morphology compared to white matter GPCs and their mouse counterparts.
Review
Multidisciplinary Sciences
Baljit S. Khakh, Steven A. Goldman
Summary: Huntington's disease (HD) is a fatal neurodegenerative disease caused by a mutation in the huntingtin gene. Astrocytes in the striatum, a brain region affected in HD, play a role in the pathology of the disease. Dysfunctions in astrocytes contribute to cellular and metabolic abnormalities in HD, suggesting the potential for therapeutic targeting of these cells to restore normal function.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Review
Multidisciplinary Sciences
Jeffrey A. Stogsdill, Corey C. Harwell, Steven A. Goldman
Summary: Astrocytes are crucial for the development, plasticity, and maintenance of neural circuits in the central nervous system. They have diverse functions and play integral roles in regulating neural activity. Dysfunction of astrocytes has been implicated in various neurodegenerative and neuropsychiatric disorders. This review focuses on the contributions of astrocytes to synaptic development and maturation, as well as their role in supporting myelin integrity and potential therapeutic strategies targeting these cells.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Multidisciplinary Sciences
Carlos Benitez Villanueva, Hans J. T. Stephensen, Rajmund Mokso, Abdellatif Benraiss, Jon Sporring, Steven A. Goldman
Summary: This study investigates the relationship between astroglial cells and medium spiny neurons (MSN) synapses in Huntington's disease (HD). The results show that HD astrocytes have impaired connection and function with synaptic sites compared to normal astrocytes, leading to striatal hyperexcitability and the development of HD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell & Tissue Engineering
Martha S. Windrem, Mikhail Osipovitch, Zhengshan Liu, Janna Bates, Devin Chandler-Militello, Lisa Zou, Jared Munir, Steven Schanz, Katherine Mccoy, Robert H. Miller, Su Wang, Maiken Nedergaard, Robert L. Findling, Paul J. Tesar, Steven A. Goldman
Article
Genetics & Heredity
Zachary S. Nevin, Daniel C. Factor, Robert T. Karl, Panagiotis Douvaras, Jeremy Laukka, Martha S. Windrem, Steven A. Goldman, Valentina Fossati, Grace M. Hobson, Paul J. Tesar
AMERICAN JOURNAL OF HUMAN GENETICS
(2017)