The lymphatic vasculature in disease

Signal transduction by vascular endothelial growth factor receptors

(2011) Sina Koch et al.   BIOCHEMICAL JOURNAL

An important role of lymphatic vessel activation in limiting acute inflammation

(2011) R. Huggenberger et al.   BLOOD

Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor

(2011) W. Zheng et al.   BLOOD

The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development

(2011) K. Niessen et al.   BLOOD

Biological Basis of Therapeutic Lymphangiogenesis

(2011) Camilla Norrmén et al.   CIRCULATION

Growth Factor Therapy and Autologous Lymph Node Transfer in Lymphedema

(2011) Markku Lähteenvuo et al.   CIRCULATION

CCBE1 Is Essential for Mammalian Lymphatic Vascular Development and Enhances the Lymphangiogenic Effect of Vascular Endothelial Growth Factor-C In Vivo

(2011) Frank L. Bos et al.   CIRCULATION RESEARCH

Role of the lymphatic system in the pathogenesis of Crohnʼs disease

(2011) Pierre-Yves von der Weid et al.   CURRENT OPINION IN GASTROENTEROLOGY

Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax

(2011) John D. Kanady et al.   DEVELOPMENTAL BIOLOGY

Structural analysis of vascular endothelial growth factor receptor-2/ligand complexes by small-angle X-ray solution scattering

(2011) Kaisa Kisko et al.   FASEB JOURNAL

T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel Formation

(2011) Raghu P. Kataru et al.   IMMUNITY

Do all roads lead to Rome? Routes to metastasis development

(2011) Jonathan P. Sleeman et al.   INTERNATIONAL JOURNAL OF CANCER

Molecular mechanisms of lymphangiogenesis in development and cancer

(2011) Imke Albrecht et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Association of Occult Metastases in Sentinel Lymph Nodes and Bone Marrow With Survival Among Women With Early-Stage Invasive Breast Cancer

(2011) Armando E. Giuliano et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Lymphatic vascular morphogenesis in development, physiology, and disease

(2011) Stefan Schulte-Merker et al.   JOURNAL OF CELL BIOLOGY

Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse

(2011) Dontscho Kerjaschki et al.   JOURNAL OF CLINICAL INVESTIGATION

Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice

(2011) Eleni Bazigou et al.   JOURNAL OF CLINICAL INVESTIGATION

DC mobilization from the skin requires docking to immobilized CCL21 on lymphatic endothelium and intralymphatic crawling

(2011) Orna Tal et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Critical Role for Dendritic Cells in the Formation of Lymphatic Vessels within Tertiary Lymphoid Structures

(2011) L. R. Muniz et al.   JOURNAL OF IMMUNOLOGY

An Antibody Targeted to VEGFR-2 Ig Domains 4-7 Inhibits VEGFR-2 Activation and VEGFR-2-Dependent Angiogenesis without Affecting Ligand Binding

(2011) J. Kendrew et al.   MOLECULAR CANCER THERAPEUTICS

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling

(2011) Tuomas Tammela et al.   NATURE CELL BIOLOGY

Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome)

(2011) Pia Ostergaard et al.   NATURE GENETICS

Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis

(2011) Francis X. McCormack et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Photodynamic Ablation of Lymphatic Vessels and Intralymphatic Cancer Cells Prevents Metastasis

(2011) T. Tammela et al.   Science Translational Medicine

Targeting Lymphangiogenesis After Islet Transplantation Prolongs Islet Allograft Survival

(2011) Na Yin et al.   TRANSPLANTATION

GJC2 Missense Mutations Cause Human Lymphedema

(2010) Robert E. Ferrell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Dermal Collagen and Lipid Deposition Correlate with Tissue Swelling and Hydraulic Conductivity in Murine Primary Lymphedema

(2010) Joseph M. Rutkowski et al.   AMERICAN JOURNAL OF PATHOLOGY

Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation

(2010) P. Uhrin et al.   BLOOD

Structural determinants of vascular endothelial growth factor-D receptor binding and specificity

(2010) V.-M. Leppanen et al.   BLOOD

Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling

(2010) C. C. Bertozzi et al.   BLOOD

Lymphotoxin-alpha contributes to lymphangiogenesis

(2010) R. H. Mounzer et al.   BLOOD

Double Antiangiogenic Protein, DAAP, Targeting VEGF-A and Angiopoietins in Tumor Angiogenesis, Metastasis, and Vascular Leakage

(2010) Young Jun Koh et al.   CANCER CELL

Effective Suppression of Vascular Network Formation by Combination of Antibodies Blocking VEGFR Ligand Binding and Receptor Dimerization

(2010) Denis Tvorogov et al.   CANCER CELL

In vivo Imaging of Inflammation- and Tumor-Induced Lymph Node Lymphangiogenesis by Immuno-Positron Emission Tomography

(2010) V. Mumprecht et al.   CANCER RESEARCH

CXCR4 Signaling Regulates Metastasis of Chemoresistant Melanoma Cells by a Lymphatic Metastatic Niche

(2010) M. Kim et al.   CANCER RESEARCH

Quantitative Imaging of Lymphatic Function with Liposomal Indocyanine Green

(2010) S. T. Proulx et al.   CANCER RESEARCH

Complementary Actions of Inhibitors of Angiopoietin-2 and VEGF on Tumor Angiogenesis and Growth

(2010) H. Hashizume et al.   CANCER RESEARCH

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

Targeting Lymphatic Vessel Activation and CCL21 Production by Vascular Endothelial Growth Factor Receptor-3 Inhibition Has Novel Immunomodulatory and Antiarteriosclerotic Effects in Cardiac Allografts

(2010) Antti I. Nykänen et al.   CIRCULATION

Transmural Flow Modulates Cell and Fluid Transport Functions of Lymphatic Endothelium

(2010) Dimana O. Miteva et al.   CIRCULATION RESEARCH

Endothelial Cell Adhesion to the Extracellular Matrix Induces c-Src–Dependent VEGFR-3 Phosphorylation Without the Activation of the Receptor Intrinsic Kinase Activity

(2010) Federico Galvagni et al.   CIRCULATION RESEARCH

Cancer Dissemination—Lessons from Leukocytes

(2010) Chris D. Madsen et al.   DEVELOPMENTAL CELL

Lymphatic vasculature is increased in heart valves, ischaemic and inflamed hearts and in cholesterol-rich and calcified atherosclerotic lesions

(2010) Ivana Kholová et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development

(2010) P. Saharinen et al.   GENES & DEVELOPMENT

The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells

(2010) R. S. Srinivasan et al.   GENES & DEVELOPMENT

Endothelial Heparan Sulfate Controls Chemokine Presentation in Recruitment of Lymphocytes and Dendritic Cells to Lymph Nodes

(2010) Xingfeng Bao et al.   IMMUNITY

Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells

(2010) Kathrin Schumann et al.   IMMUNITY

Inflammation-induced secretion of CCL21 in lymphatic endothelium is a key regulator of integrin-mediated dendritic cell transmigration

(2010) Louise A. Johnson et al.   INTERNATIONAL IMMUNOLOGY

Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo

(2010) Liang Song et al.   JOURNAL OF BIOMEDICAL OPTICS

Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3

(2010) Yunling Xu et al.   JOURNAL OF CELL BIOLOGY

Lymph node–resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation

(2010) Jarish N. Cohen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre-Clinical Models

(2010) DAI FUKUMURA et al.   MICROCIRCULATION

A Human Monoclonal Anti-ANG2 Antibody Leads to Broad Antitumor Activity in Combination with VEGF Inhibitors and Chemotherapy Agents in Preclinical Models

(2010) J. L. Brown et al.   MOLECULAR CANCER THERAPEUTICS

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

(2010) Peter J. Campbell et al.   NATURE

Structural determinants of growth factor binding and specificity by VEGF receptor 2

(2010) V.-M. Leppanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling

(2010) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21

(2010) J. D. Shields et al.   SCIENCE

Lymphatic lipid transport: sewer or subway?

(2010) J. Brandon Dixon   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hypercholesterolemic Mice Exhibit Lymphatic Vessel Dysfunction and Degeneration

(2009) Hwee Ying Lim et al.   AMERICAN JOURNAL OF PATHOLOGY

KSHV-induced notch components render endothelial and mural cell characteristics and cell survival

(2009) R. Liu et al.   BLOOD

Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution

(2009) R. P. Kataru et al.   BLOOD

Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells

(2009) Andrea T. Hooper et al.   Cell Stem Cell

Activated Forms of VEGF-C and VEGF-D Provide Improved Vascular Function in Skeletal Muscle

(2009) Andrey Anisimov et al.   CIRCULATION RESEARCH

Lymphatic imaging in humans with near-infrared fluorescence

(2009) John C Rasmussen et al.   CURRENT OPINION IN BIOTECHNOLOGY

The Control of Vascular Integrity by Endothelial Cell Junctions: Molecular Basis and Pathological Implications

(2009) Elisabetta Dejana et al.   DEVELOPMENTAL CELL

Clever-1/Stabilin-1 regulates lymphocyte migration within lymphatics and leukocyte entrance to sites of inflammation

(2009) Marika Karikoski et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The lymphatic system controls intestinal inflammation and inflammation-associated colon cancer through the chemokine decoy receptor D6

(2009) S. Vetrano et al.   GUT

Conduits Mediate Transport of Low-Molecular-Weight Antigen to Lymph Node Follicles

(2009) Ramon Roozendaal et al.   IMMUNITY

Genetic disparity between primary tumours, disseminated tumour cells, and manifest metastasis

(2009) Nikolas H. Stoecklein et al.   INTERNATIONAL JOURNAL OF CANCER

FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1

(2009) Camilla Norrmén et al.   JOURNAL OF CELL BIOLOGY

Lymphotoxin β receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of agedApoE−/−mice

(2009) Rolf Gräbner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels

(2009) Holger Pflicke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mast cell–derived particles deliver peripheral signals to remote lymph nodes

(2009) Christian A. Kunder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning

(2009) Trung H.M. Pham et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflamed Lymphatic Endothelium Suppresses Dendritic Cell Maturation and Function via Mac-1/ICAM-1-Dependent Mechanism

(2009) S. Podgrabinska et al.   JOURNAL OF IMMUNOLOGY

LT R Signaling Induces Cytokine Expression and Up-Regulates Lymphangiogenic Factors in Lymph Node Anlagen

(2009) M. F. Vondenhoff et al.   JOURNAL OF IMMUNOLOGY

Visualization of Tumor Blockage and Rerouting of Lymphatic Drainage in Penile Cancer Patients by Use of SPECT/CT

(2009) J. A.P. Leijte et al.   JOURNAL OF NUCLEAR MEDICINE

Inflammation in Atherosclerosis

(2009) Peter Libby et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Recent Advances in Breast Cancer-Related Lymphedema of the Arm: Lymphatic Pump Failure and Predisposing Factors

(2009) Anthony W.B. Stanton et al.   Lymphatic Research and Biology

ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

(2009) Benjamin M Hogan et al.   NATURE GENETICS

Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation

(2009) Tri Giang Phan et al.   NATURE IMMUNOLOGY

Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging

(2009) Benjamin J Vakoc et al.   NATURE MEDICINE

Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth

(2009) Romulo J C Albuquerque et al.   NATURE MEDICINE

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism

(2009) Agnes Machnik et al.   NATURE MEDICINE

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lymph node tumor metastases: more susceptible than primary tumors to CD8+ T-cell immune destruction

(2009) Emmanuel Contassot et al.   TRENDS IN IMMUNOLOGY

Lymphatic Precollectors Contain a Novel, Specialized Subpopulation of Podoplaninlow, CCL27-Expressing Lymphatic Endothelial Cells

(2008) Nikolaus Wick et al.   AMERICAN JOURNAL OF PATHOLOGY

The Link between Lymphatic Function and Adipose Biology

(2008) Natasha L. Harvey   Annals of the New York Academy of Sciences

Toll-like receptor 4 in lymphatic endothelial cells contributes to LPS-induced lymphangiogenesis by chemotactic recruitment of macrophages

(2008) S. Kang et al.   BLOOD

Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis

(2008) Maresa Caunt et al.   CANCER CELL

Lymph sacs are not required for the initiation of lymph node formation

(2008) M. F. Vondenhoff et al.   DEVELOPMENT

Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node

(2008) Friederike Pfeiffer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mechanisms and Consequences of Dendritic Cell Migration

(2008) David Alvarez et al.   IMMUNITY

Prevalence of Lymphedema in Women With Breast Cancer 5 Years After Sentinel Lymph Node Biopsy or Axillary Dissection: Objective Measurements

(2008) Sarah A. McLaughlin et al.   JOURNAL OF CLINICAL ONCOLOGY

The Lymphatic System in Health and Disease

(2008) Leah N. Cueni et al.   Lymphatic Research and Biology

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

(2008) Tuomas Tammela et al.   NATURE

Sox18 induces development of the lymphatic vasculature in mice

(2008) Mathias François et al.   NATURE

Rapid leukocyte migration by integrin-independent flowing and squeezing

(2008) Tim Lämmermann et al.   NATURE