Exposing the exposures responsible for type 2 diabetes and obesity

Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity

(2016) Kevin Dalgaard et al.   CELL

Putting the Genome in Context: Gene-Environment Interactions in Type 2 Diabetes

(2016) Paul W. Franks et al.   Current Diabetes Reports

Unravelling the complex mechanisms of transgenerational epigenetic inheritance

(2016) Georgina ET Blake et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Metabolic Effects of Monounsaturated Fatty Acid–Enriched Diets Compared With Carbohydrate or Polyunsaturated Fatty Acid–Enriched Diets in Patients With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials

(2016) Frank Qian et al.   DIABETES CARE

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

Population-level analysis of gut microbiome variation

(2016) Gwen Falony et al.   SCIENCE

Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota

(2016) Albert Palleja et al.   Genome Medicine

Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci

(2016) Samuel E. Jones et al.   PLoS Genetics

Personalized Nutrition by Prediction of Glycemic Responses

(2015) David Zeevi et al.   CELL

Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome

(2015) Siegfried Ussar et al.   Cell Metabolism

Genetic Predisposition to Weight Loss and Regain With Lifestyle Intervention: Analyses From the Diabetes Prevention Program and the Look AHEAD Randomized Controlled Trials

(2015) George D. Papandonatos et al.   DIABETES

Effect of Vitamin D Supplementation on Glycemic Control in Patients With Type 2 Diabetes (SUNNY Trial): A Randomized Placebo-Controlled Trial

(2015) Yvonne H.M. Krul-Poel et al.   DIABETES CARE

Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry

(2015) Jennifer A. Nettleton et al.   HUMAN MOLECULAR GENETICS

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

(2015) Kristoffer Forslund et al.   NATURE

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

(2015) Jian Yang et al.   NATURE GENETICS

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Greenlandic Inuit show genetic signatures of diet and climate adaptation

(2015) M. Fumagalli et al.   SCIENCE

Food Preference Patterns in a UK Twin Cohort

(2015) Tess Pallister et al.   Twin Research and Human Genetics

The Concordance and Heritability of Type 2 Diabetes in 34,166 Twin Pairs From International Twin Registers: The Discordant Twin (DISCOTWIN) Consortium

(2015) Gonneke Willemsen et al.   Twin Research and Human Genetics

Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study

(2015) Zheng Ye et al.   Lancet Diabetes & Endocrinology

Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study

(2015) John C Chambers et al.   Lancet Diabetes & Endocrinology

Human Genetics Shape the Gut Microbiome

(2014) Julia K. Goodrich et al.   CELL

Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences

(2014) Laura M. Cox et al.   CELL

FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals

(2014) Qibin Qi et al.   HUMAN MOLECULAR GENETICS

DNA methylation and body-mass index: a genome-wide analysis

(2014) Katherine J Dick et al.   LANCET

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

(2014) Ida Moltke et al.   NATURE

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

(2014) Anubha Mahajan et al.   NATURE GENETICS

Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies

(2014) Q. Qi et al.   BMJ-British Medical Journal

Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study

(2014) Claudia Langenberg et al.   PLOS MEDICINE

Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake

(2013) Toshiko Tanaka et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Inference of the Genetic Architecture Underlying BMI and Height with the Use of 20,240 Sibling Pairs

(2013) Gibran Hemani et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Gene × Environment Interactions in Obesity: The State of the Evidence

(2013) Shafqat Ahmad et al.   HUMAN HEREDITY

Parental diabetes and birthweight in 236 030 individuals in the UK Biobank Study

(2013) J. S. Tyrrell et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Gut metagenome in European women with normal, impaired and diabetic glucose control

(2013) Fredrik H. Karlsson et al.   NATURE

Evaluating empirical bounds on complex disease genetic architecture

(2013) Vineeta Agarwala et al.   NATURE GENETICS

Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry

(2013) Shafqat Ahmad et al.   PLoS Genetics

Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts

(2013) Karani S. Vimaleswaran et al.   PLOS MEDICINE

Television Watching, Leisure Time Physical Activity, and the Genetic Predisposition in Relation to Body Mass Index in Women and Men

(2012) Qibin Qi et al.   CIRCULATION

Cardiovascular mortality in relation to birth weight of children and grandchildren in 500 000 Norwegian families

(2012) Oyvind Naess et al.   EUROPEAN HEART JOURNAL

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

(2012) Anne Vrieze et al.   GASTROENTEROLOGY

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

Sugar-Sweetened Beverages and Genetic Risk of Obesity

(2012) Qibin Qi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Updated Genetic Score Based on 34 Confirmed Type 2 Diabetes Loci Is Associated With Diabetes Incidence and Regression to Normoglycemia in the Diabetes Prevention Program

(2011) M.-F. Hivert et al.   DIABETES

Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

(2011) Tuomas O. Kilpeläinen et al.   PLOS MEDICINE

Challenges in the Use of Literature-based Meta-Analysis to Examine Gene-Environment Interactions

(2010) L. Palla et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Developmental origins of metabolic disease: life course and intergenerational perspectives

(2010) Keith M. Godfrey et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study

(2009)   LANCET

Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates

(2009) Frank M. Sacks et al.   NEW ENGLAND JOURNAL OF MEDICINE

Strengthening causal inference in cardiovascular epidemiology through Mendelian randomization

(2008) George Davey Smith et al.   ANNALS OF MEDICINE

Association Between Maternal Diabetes in Utero and Age at Offspring's Diagnosis of Type 2 Diabetes

(2008) D. J. Pettitt et al.   DIABETES CARE