Designer protein delivery: From natural to engineered affinity-controlled release systems

Covalent Docking Predicts Substrates for Haloalkanoate Dehalogenase Superfamily Phosphatases

(2015) Nir London et al.   BIOCHEMISTRY

Challenges and opportunities for non-antibody scaffold drugs

(2015) Rodrigo Vazquez-Lombardi et al.   DRUG DISCOVERY TODAY

Mathematical model accurately predicts protein release from an affinity-based delivery system

(2015) Katarina Vulic et al.   JOURNAL OF CONTROLLED RELEASE

Economical analysis of saturation mutagenesis experiments

(2015) Carlos G. Acevedo-Rocha et al.   Scientific Reports

Affinity-Based Drug Delivery Systems for Tissue Repair and Regeneration

(2014) Katarina Vulic et al.   BIOMACROMOLECULES

Long-term delivery of protein therapeutics

(2014) Ravi Vaishya et al.   Expert Opinion on Drug Delivery

Incorporation of protein flexibility and conformational energy penalties in docking screens to improve ligand discovery

(2014) Marcus Fischer et al.   Nature Chemistry

Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

(2014) Samir Mitragotri et al.   NATURE REVIEWS DRUG DISCOVERY

Determination of protein binding affinities within hydrogel-based molecularly imprinted polymers (HydroMIPs)

(2014) Hazim F. EL-Sharif et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Computational Design of Binding Proteins to EGFR Domain II

(2014) Yoon Sup Choi et al.   PLoS One

Engineering of Bispecific Affinity Proteins with High Affinity for ERBB2 and Adaptable Binding to Albumin

(2014) Johan Nilvebrant et al.   PLoS One

Computational design of a pH-sensitive IgG binding protein

(2014) E.-M. Strauch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum Stable Natural Peptides Designed by mRNA Display

(2014) Shannon M. Howell et al.   Scientific Reports

In Vitro Selection of Shape-Changing DNA Nanostructures Capable of Binding-Induced Cargo Release

(2013) Seung Soo Oh et al.   ACS Nano

Incorporation of heparin into biomaterials

(2013) Shelly E. Sakiyama-Elbert   Acta Biomaterialia

Affinity-based release of chondroitinase ABC from a modified methylcellulose hydrogel

(2013) Malgosia M. Pakulska et al.   JOURNAL OF CONTROLLED RELEASE

Computational Design of a Protein-Based Enzyme Inhibitor

(2013) Erik Procko et al.   JOURNAL OF MOLECULAR BIOLOGY

Computational design of ligand-binding proteins with high affinity and selectivity

(2013) Christine E. Tinberg et al.   NATURE

Vascular endothelial growth factor in heart failure

(2013) Ziad Taimeh et al.   Nature Reviews Cardiology

First-in-Human Phase I Study of PRS-050 (Angiocal), an Anticalin Targeting and Antagonizing VEGF-A, in Patients with Advanced Solid Tumors

(2013) Klaus Mross et al.   PLoS One

Quantitative selection and parallel characterization of aptamers

(2013) M. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tolerance of the archaeal Sac7d scaffold protein to alternative library designs: characterization of anti-immunoglobulin G Affitins

(2013) G. Behar et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Enhanced Loading and Controlled Release of Antibiotics Using Nucleic Acids As an Antibiotic-Binding Effector in Hydrogels

(2012) Xiaolong Zhang et al.   BIOMACROMOLECULES

Synthetic antibodies: Concepts, potential and practical considerations

(2012) S. Miersch et al.   METHODS

Directed Evolution of a Fluorogen-Activating Single Chain Antibody for Function and Enhanced Brightness in the Cytoplasm

(2012) Bradley P. Yates et al.   MOLECULAR BIOTECHNOLOGY

Label-free measuring and mapping of binding kinetics of membrane proteins in single living cells

(2012) Wei Wang et al.   Nature Chemistry

Massively parallel measurements of molecular interaction kinetics on a microfluidic platform

(2012) M. Geertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reducing Codon Redundancy and Screening Effort of Combinatorial Protein Libraries Created by Saturation Mutagenesis

(2012) Sabrina Kille et al.   ACS Synthetic Biology

Experimental Studies and Modeling of Drug Release from a Tunable Affinity-Based Drug Delivery Platform

(2011) Andrew S. Fu et al.   ANNALS OF BIOMEDICAL ENGINEERING

Affinity-based growth factor delivery using biodegradable, photocrosslinked heparin-alginate hydrogels

(2011) Oju Jeon et al.   JOURNAL OF CONTROLLED RELEASE

Teaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 Scaffold

(2011) Akiko Koide et al.   JOURNAL OF MOLECULAR BIOLOGY

Tunable Growth Factor Delivery from Injectable Hydrogels for Tissue Engineering

(2011) Katarina Vulic et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor

(2011) Stuart L. Emanuel et al.   mAbs

A De Novo Protein Binding Pair By Computational Design and Directed Evolution

(2011) John Karanicolas et al.   MOLECULAR CELL

Protein engineering: navigating between chance and reason

(2011) Monya Baker   NATURE METHODS

MimoDB 2.0: a mimotope database and beyond

(2011) J. Huang et al.   NUCLEIC ACIDS RESEARCH

Computational design of protein–ligand interfaces: potential in therapeutic development

(2011) Andrew Morin et al.   TRENDS IN BIOTECHNOLOGY

Photopolymerizable Hydrogels Made from Polymer-Conjugated Albumin for Affinity-Based Drug Delivery

(2010) Liat Oss-Ronen et al.   ADVANCED ENGINEERING MATERIALS

Drug–protein binding: a critical review of analytical tools

(2010) Karine Vuignier et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Measurement of Protein−Ligand Binding Constants from Reaction-Diffusion Concentration Profiles

(2010) Yanhu Wei et al.   ANALYTICAL CHEMISTRY

Development of FRET Assay into Quantitative and High-throughput Screening Technology Platforms for Protein–Protein Interactions

(2010) Yang Song et al.   ANNALS OF BIOMEDICAL ENGINEERING

Developments in the therapeutic use of erythropoiesis stimulating agents

(2010) Wolfgang Jelkmann   BRITISH JOURNAL OF HAEMATOLOGY

Hydrogel functionalization with DNA aptamers for sustained PDGF-BB release

(2010) Boonchoy Soontornworajit et al.   CHEMICAL COMMUNICATIONS

Higher throughput calorimetry: opportunities, approaches and challenges

(2010) Francisco E Torres et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Design of an Optimized Scaffold for Affibody Molecules

(2010) Joachim Feldwisch et al.   JOURNAL OF MOLECULAR BIOLOGY

Parallel microfluidic surface plasmon resonance imaging arrays

(2010) Eric Ouellet et al.   LAB ON A CHIP

Affinity-Based Drug Delivery

(2010) Nick X. Wang et al.   MACROMOLECULAR BIOSCIENCE

The influence of the sequential delivery of angiogenic factors from affinity-binding alginate scaffolds on vascularization

(2009) Inbar Freeman et al.   BIOMATERIALS

Discovery and development of biopharmaceuticals: current issues

(2009) William R Strohl et al.   CURRENT OPINION IN BIOTECHNOLOGY

Anti-VEGF agents for age-related macular degeneration

(2009) Abdullah Özkiris   EXPERT OPINION ON THERAPEUTIC PATENTS

The osteogenic effect of bone morphogenetic protein-2 on the collagen scaffold conjugated with antibodies

(2009) Yannan Zhao et al.   JOURNAL OF CONTROLLED RELEASE

An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies

(2009) D. Schonfeld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymer-Based Sustained-Release Dosage Forms for Protein Drugs, Challenges, and Recent Advances

(2008) Fei Wu et al.   AAPS PHARMSCITECH

The effect of sulfation of alginate hydrogels on the specific binding and controlled release of heparin-binding proteins

(2008) Inbar Freeman et al.   BIOMATERIALS

A Decade of Yeast Surface Display Technology: Where Are We Now?

(2008) Eric Shusta et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

A review of stimuli-responsive nanocarriers for drug and gene delivery

(2008) Srinivas Ganta et al.   JOURNAL OF CONTROLLED RELEASE

Kemp elimination catalysts by computational enzyme design

(2008) Daniela Röthlisberger et al.   NATURE

De Novo Computational Design of Retro-Aldol Enzymes

(2008) L. Jiang et al.   SCIENCE