Article
Chemistry, Applied
Baharak Divband, Marziyeh Aghazadeh, Zahraa Haleem Al-qaim, Mohammad Samiei, Falah H. Hussein, Alireza Shaabani, Shahriar Shahi, Roya Sedghi
Summary: Injectable hydrogels loaded with VEGF and BMP-2 promote proliferation and osteogenic differentiation of DPSCs, showing potential for bone defect treatment.
CARBOHYDRATE POLYMERS
(2021)
Review
Biotechnology & Applied Microbiology
Saba Salehi, Seyed Morteza Naghib, Hamid Reza Garshasbi, Sadegh Ghorbanzadeh, Wei Zhang
Summary: Hydrogels are widely used biomaterials for therapeutic agent delivery and tissue engineering due to their biocompatibility and similarity to natural body tissues. Some substances have injectable properties, allowing for minimally invasive administration. Gelation can be induced by stimuli, making the material stimuli-responsive. This article introduces various stimuli for gelation and investigates the mechanisms of solution-to-gel transformation, while also studying special structures such as nano gels or nanocomposite gels.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Senbo Zhu, Yong Li, Zeju He, Lichen Ji, Wei Zhang, Yu Tong, Junchao Luo, Dongsheng Yu, Qiong Zhang, Qing Bi
Summary: This paper reviews the research progress on advanced injectable hydrogels for repairing cartilage defects. It thoroughly discusses the cross-linking method and structure of injectable hydrogels, and reviews the commonly used polymers, cells, and stimulators in their preparation. Finally, it summarizes the research progress of the latest advanced hydrogels for cartilage repair and the future challenges for injectable hydrogels.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Pascal Bertsch, Mani Diba, David J. Mooney, Sander C. G. Leeuwenburgh
Summary: Biomaterials that can self-heal and maintain their structural integrity have significant advantages in biomedicine. Self-healing injectable hydrogels, a new type of biomaterial, have emerged in the past decade. These hydrogels can temporarily fluidize and then recover their mechanical properties under shear stress. They can be administered locally and minimally invasively, and have moldable properties for personalized medicine. Additionally, they facilitate tissue regeneration through their viscoelastic and diffusive nature. However, challenges remain in balancing self-healing and injectability with physical stability, establishing consensus on rheological characterization, and translating them into therapeutically effective formulations for specific tissues.
Article
Engineering, Biomedical
Melissa J. J. van Velthoven, Aksel N. Gudde, Evert Arendsen, Jan-Paul Roovers, Zeliha Guler, Egbert Oosterwijk, Paul H. J. Kouwer
Summary: With its involvement in cell proliferation, migration and differentiation, bFGF has potential for tissue engineering purposes. However, clinical translation of soluble bFGF-based therapies is unsuccessful due to high doses and adverse effects. Growth factor immobilization, such as in PIC-bFGF hydrogel, can enhance bioactivity. This study demonstrates the potential of simple biological conjugation procedures to induce additional bioactivity in synthetic cell culture matrices.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Mithun Rajendra Dethe, A. Prabakaran, Hafiz Ahmed, Mukta Agrawal, Upal Roy, Amit Alexander
Summary: Stimuli-responsive hydrogels have been extensively studied in biomedical applications due to their biodegradability and biocompatibility. The emergence of in situ stimuli-responsive hydrogels is the result of advancements in synthetic chemistry and materials science. The copolymer PCL-PEG, recognized by the FDA, can form thermosensitive injectable hydrogels that exhibit rapid and reversible gelation behavior.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biophysics
Reza Karimi-Soflou, Sara Nejati, Akbar Karkhaneh
Summary: Injectable in-situ forming electroconductive hydrogels with antioxidant activity have been successfully synthesized, showing improved rheological properties with the introduction of PEI and increased antioxidant activity and pore size by increasing polyaniline content. Cell studies demonstrated that the hydrogels supported neural cell growth, with neurite elongation observed in the presence of external electrical stimulus.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Pharmacology & Pharmacy
Svenja Meissner, Brad Raos, Darren Svirskis
Summary: Growth factors (GFs) have a wide range of biological functions and their potential in tissue engineering is still being explored. Incorporating GFs into hydrogels can improve their efficacy and target specific tissues. This review discusses the formation and key properties of GF-loaded hydrogels, as well as their in vivo performance and efficacy.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Xiang Lin, Jinglin Wang, Xiangyi Wu, Yuan Luo, Yongan Wang, Yuanjin Zhao
Summary: Marine organisms provide valuable resources for biomaterials, especially natural hydrogels, which have outstanding bioactivity and biocompatibility. These hydrogels can not only mimic tissue extracellular matrix but also be applied in biomedicine through various techniques. This review summarizes the classification and characteristics of marine-derived hydrogels, introduces their role in biomaterial development, and discusses the influence of hydrogel types on their functions in biomedical applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Engineering, Biomedical
Chaojie Yu, Fanglian Yao, Junjie Li
Summary: Recently, injectable conducting polymer-based hydrogels have gained attention in tissue engineering due to their controlled conductivity and minimally invasive procedures. Functional CPs play a crucial role in designing these hydrogels and have potential applications in neurological treatment, myocardial repair, and skeletal muscle regeneration.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Hongwei Pan, Wanxin Li, Yue Qu, Simei Li, Ayixiemu Yusufu, Jia Wang, Lihua Yin
Summary: This study successfully developed a series of injectable hydrogels for bone defect repair caused by trauma or tumor. The hydrogels exhibited excellent mechanical properties and biodegradability, and could provide a favorable microenvironment for the growth and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Review
Biochemistry & Molecular Biology
Parisa Ghandforoushan, Morteza Alehosseini, Nasim Golafshan, Miguel Castilho, Alireza Dolatshahi-Pirouz, Jalal Hanaee, Soodabeh Davaran, Gorka Orive
Summary: Millions of patients annually suffer from irreversible injury to organs or tissues due to accidents, aging, or disease. Injectable hydrogels combined with stem cell science have emerged as a solution, providing minimally invasive treatments to enhance tissue function. Hydrogels, made up of cross-linked polymers, mimic the moist environment of natural cells and can be used as needle-injectable stem cell carriers for tissue repair. With their versatile properties such as biocompatibility and tunable biological and physicochemical properties, hydrogels are increasingly being used to improve the quality of life for those with tissue-related diseases. This review highlights the applications of injectable hydrogel-based biomaterials, particularly in bone and cartilage tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Yunfei Tan, Lei Ma, Xiangyu Chen, Yaqin Ran, Qiulan Tong, Liwen Tang, Xudong Li
Summary: The interfacial mismatch between rigid hydroxyapatite and soft polysaccharide phase in natural polysaccharide/hydroxyapatite hydrogels remains a challenge in bone tissue engineering. In this study, hyaluronic acid was used as a template for biological mineralization to synthesize hyaluronic acid/hydroxyapatite hybrid particles. These particles were then introduced into hydroxyapatite composite hydrogels, which showed increased storage modulus and excellent cytocompatibility. The self-healing hydrogels, suitable for cell encapsulation, hold promise for bone defect repair.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
Arjan Atwal, Tina P. Dale, Martyn Snow, Nicholas R. Forsyth, Pooya Davoodi
Summary: The impairment of articular cartilage poses challenges, but recent advancements in regenerative medicine, particularly the use of injectable hydrogels, offer promising prospects for cartilage regeneration. Hydrogels can mimic the characteristics of native cartilage and provide minimally invasive delivery of bioactive agents to the damaged site, accelerating cartilage healing and modulating inflammation.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Article
Engineering, Biomedical
Omar Alheib, Lucilia P. da Silva, Alain da Silva Morais, Katia A. Mesquita, Rogerio P. Pirraco, Rui L. Reis, Vitor M. Conrelo
Summary: We developed an injectable gellan gum-based hydrogel that delivers C2C12 into a localized myopathic model. The gellan gum was biofunctionalized with a laminin-derived peptide to mimic the natural muscular extracellular matrix. Furthermore, the hydrogel was physically adjusted to replicate the mechanical properties of native tissue. This formula was utilized for the first time in the field of skeletal muscle tissue regeneration. The injectability of the hydrogel allowed for non-invasive administration, creating a reliable microenvironment that supported C2C12 with minimal inflammation. The treatment of skeletal muscle defects with the cell-laden hydrogel significantly enhanced regeneration of localized muscular trauma.
ACTA BIOMATERIALIA
(2022)
