MD-2 is required for disulfide HMGB1–dependent TLR4 signaling

Targeting HMGB1 in the treatment of sepsis

(2014) Haichao Wang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

(2013) Daniel J. Antoine et al.   HEPATOLOGY

Lipopolysaccharide Clearance, Bacterial Clearance, and Systemic Inflammatory Responses Are Regulated by Cell Type-Specific Functions of TLR4 during Sepsis

(2013) M. Deng et al.   JOURNAL OF IMMUNOLOGY

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

(2013) Huan Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Unknown

(2013) Daolin Tang et al.   MOLECULAR MEDICINE

High-Mobility Group Box 1 Mediates Persistent Splenocyte Priming in Sepsis Survivors

(2013) Sergio I. Valdés-Ferrer et al.   SHOCK

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

(2012) Daniel J. Antoine et al.   JOURNAL OF HEPATOLOGY

Unknown

(2012) Huan Yang et al.   MOLECULAR MEDICINE

Insights into binding modes of tumstatin peptide T7 with the active site of αvβ3integrin

(2012) Jinhang Zan et al.   MOLECULAR SIMULATION

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MD-2-mediated Ionic Interactions between Lipid A and TLR4 Are Essential for Receptor Activation

(2009) Jianmin Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-Like Receptor 4 Deficiency Increases Disease and Mortality after Mouse Hepatitis Virus Type 1 Infection of Susceptible C3H Mice

(2009) A. Khanolkar et al.   JOURNAL OF VIROLOGY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses

(2009) G.-Y. Chen et al.   SCIENCE

Isolation of Monomeric and Dimeric Secreted MD-2

(2008) Athmane Teghanemt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY