Musashi-2 (MSI2) supports TGF-β signaling and inhibits claudins to promote non-small cell lung cancer (NSCLC) metastasis

Transformation of the intestinal epithelium by the MSI2 RNA-binding protein

(2015) Shan Wang et al.   Nature Communications

An novel inhibitor of TGF-β type I receptor, IN-1130, blocks breast cancer lung metastasis through inhibition of epithelial–mesenchymal transition

(2014) Chul-Yong Park et al.   CANCER LETTERS

EGFR Blockade Enriches for Lung Cancer Stem-like Cells through Notch3-Dependent Signaling

(2014) R. R. Arasada et al.   CANCER RESEARCH

Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs

(2014) Sun-Mi Park et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intrinsic basal and luminal subtypes of muscle-invasive bladder cancer

(2014) Woonyoung Choi et al.   Nature Reviews Urology

Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer

(2014) Tim N. Beck et al.   PHYSIOLOGICAL GENOMICS

Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity

(2014) Aleix Prat et al.   Scientific Reports

Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state

(2014) Yarden Katz et al.   eLife

Cancer statistics, 2013

(2013) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Notch1 Is Required for Kras-Induced Lung Adenocarcinoma and Controls Tumor Cell Survival via p53

(2013) S. Licciulli et al.   CANCER RESEARCH

Notch Pathway Activity Identifies Cells with Cancer Stem Cell-like Properties and Correlates with Worse Survival in Lung Adenocarcinoma

(2013) K. A. Hassan et al.   CLINICAL CANCER RESEARCH

Emerging Roles of Claudins in Human Cancer

(2013) Mi Kwon   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential Inhibition of the TGF-β Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-β Receptor Type II

(2013) Francesco Dituri et al.   PLoS One

TGF-β1 exposure induces epithelial to mesenchymal transition both in CSCs and non-CSCs of the A549 cell line, leading to an increase of migration ability in the CD133+ A549 cell fraction

(2013) V Tirino et al.   Cell Death & Disease

Suppression of SCARA5 by Snail1 is essential for EMT-associated cell migration of A549 cells

(2013) J Liu et al.   Oncogenesis

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TGFβ induces the formation of tumour-initiating cells in claudinlow breast cancer

(2012) Alejandra Bruna et al.   Nature Communications

Msi-1 is a Predictor of Survival and a Novel Therapeutic Target in Colon Cancer

(2011) Dawei Li et al.   ANNALS OF SURGICAL ONCOLOGY

Claudin-7 inhibits human lung cancer cell migration and invasion through ERK/MAPK signaling pathway

(2011) Zhe Lu et al.   EXPERIMENTAL CELL RESEARCH

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

(2011) Thordur Oskarsson et al.   NATURE MEDICINE

Safety of bevacizumab (BV) plus docetaxel (D) in patients (pts) with locally recurrent (LR) or metastatic breast cancer (mBC) who developed brain metastases during the AVADO phase III study.

(2010) LY Dirix et al.   CANCER RESEARCH

Identification of Optimal Drug Combinations Targeting Cellular Networks: Integrating Phospho-Proteomics and Computational Network Analysis

(2010) S. Iadevaia et al.   CANCER RESEARCH

The overexpression of the putative gut stem cell marker Musashi-1 induces tumorigenesis through Wnt and Notch activation

(2010) A. Rezza et al.   JOURNAL OF CELL SCIENCE

Regulation of myeloid leukaemia by the cell-fate determinant Musashi

(2010) Takahiro Ito et al.   NATURE

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

(2010) Michael G Kharas et al.   NATURE MEDICINE

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

(2010) A Singh et al.   ONCOGENE

Reduced expression of claudin-7 is associated with poor outcome in non-small cell lung cancer

(2010) TAKETSUGU YAMAMOTO et al.   Oncology Letters

Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression

(2009) D. L. Gibbons et al.   GENES & DEVELOPMENT

Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression

(2009) Xiaoying Zhang et al.   HEPATOLOGY

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

(2009) C. J. Creighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment

(2009) G. Bertolini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional proteomic profiling of AML predicts response and survival

(2008) S. M. Kornblau et al.   BLOOD

The Melanoma-Associated Antigen A3 Mediates Fibronectin-Controlled Cancer Progression and Metastasis

(2008) W. Liu et al.   CANCER RESEARCH

Knockdown of RNA Binding Protein Musashi-1 Leads to Tumor Regression In Vivo

(2008) Sripathi M. Sureban et al.   GASTROENTEROLOGY