Regulation of platelet lifespan by apoptosis

Regulating billions of blood platelets: glycans and beyond

(2015) R. Grozovsky et al.   BLOOD

Platelets induce apoptosis via membrane-bound FasL

(2015) R. I. Schleicher et al.   BLOOD

Coordinated Membrane Ballooning and Procoagulant Spreading in Human PlateletsClinical Perspective

(2015) Ejaife O. Agbani et al.   CIRCULATION

Hemoglobin interaction with GP1b  induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis

(2015) R. Singhal et al.   HAEMATOLOGICA

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

(2015) Joel D. Leverson et al.   Science Translational Medicine

BCL-2 is dispensable for thrombopoiesis and platelet survival

(2015) M A Debrincat et al.   Cell Death & Disease

Hemoglobin interaction with GP1b  induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis

(2015) R. Singhal et al.   HAEMATOLOGICA

Effect of thrombopoietin receptor agonists on the apoptotic profile of platelets in patients with chronic immune thrombocytopenia

(2014) William Beau Mitchell et al.   AMERICAN JOURNAL OF HEMATOLOGY

Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan

(2014) Z.-J. Liu et al.   BLOOD

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice

(2014) C J Vandenberg et al.   CELL DEATH AND DIFFERENTIATION

Platelet apoptosis in patients with acute coronary syndromes

(2014) Jinli Bao et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling

(2014) Renata Grozovsky et al.   NATURE MEDICINE

Insights into platelet-based control of coagulation

(2014) Susanne M. de Witt et al.   THROMBOSIS RESEARCH

Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL

(2014) Michael F. T. Koehler et al.   ACS Medicinal Chemistry Letters

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity

(2014) Zhi-Fu Tao et al.   ACS Medicinal Chemistry Letters

Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways

(2014) Emma C. Josefsson et al.   Nature Communications

Platelets: more than a sack of glue

(2014) A. S. Weyrich   Hematology-American Society of Hematology Education Program

Dengue induces platelet activation, mitochondrial dysfunction and cell death through mechanisms that involve DC-SIGN and caspases

(2013) E. D. Hottz et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structure-guided design of a selective BCL-XL inhibitor

(2013) Guillaume Lessene et al.   Nature Chemical Biology

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of Andrographolide-Induced Platelet Apoptosis in Human Platelets: Regulatory Roles of the Extrinsic Apoptotic Pathway

(2013) Li-Ming Lien et al.   PHYTOTHERAPY RESEARCH

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

(2013) J. Suzuki et al.   SCIENCE

Immune Thrombocytopenia Nomenclature, Consensus Reports, and Guidelines: What Are the Consequences for Daily Practice and Clinical Research?

(2013) Marc Michel   SEMINARS IN HEMATOLOGY

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice

(2012) E. Ottina et al.   BLOOD

The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways

(2012) J. M. Burkhart et al.   BLOOD

Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival

(2012) M. A. Debrincat et al.   BLOOD

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

(2012) M. J. White et al.   BLOOD

Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages

(2012) T Kodama et al.   CELL DEATH AND DIFFERENTIATION

Platelet Apoptosis and Apoptotic Platelet Clearance by Macrophages in Secondary Dengue Virus Infections

(2012) Maria Terrese G. Alonzo et al.   JOURNAL OF INFECTIOUS DISEASES

Paraneoplastic Thrombocytosis in Ovarian Cancer

(2012) Rebecca L. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiploid CD61+ Cells Are the Pre-Dominant Cell Lineage Infected during Acute Dengue Virus Infection in Bone Marrow

(2012) Kristina B. Clark et al.   PLoS One

Desialylation accelerates platelet clearance after refrigeration and initiates GPIb  metalloproteinase-mediated cleavage in mice

(2011) A. J. G. Jansen et al.   BLOOD

BCL2/BCL-XL inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation

(2011) M. Vogler et al.   BLOOD

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

(2011) S. M. Schoenwaelder et al.   BLOOD

Apoptosis in the anucleate platelet

(2011) Valery Leytin   BLOOD REVIEWS

Platelet apoptosis in paediatric immune thrombocytopenia is ameliorated by intravenous immunoglobulin

(2011) Jeannine Winkler et al.   BRITISH JOURNAL OF HAEMATOLOGY

Can the analysis of BH3-only protein knockout mice clarify the issue of ‘direct versus indirect’ activation of Bax and Bak?

(2011) A Villunger et al.   CELL DEATH AND DIFFERENTIATION

BH3-only Activator Proteins Bid and Bim Are Dispensable for Bak/Bax-dependent Thrombocyte Apoptosis Induced by Bcl-xL Deficiency

(2011) Takahiro Kodama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease

(2011) Andrew W. Roberts et al.   JOURNAL OF CLINICAL ONCOLOGY

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

(2011) Emma C. Josefsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The role of lectins and glycans in platelet clearance

(2011) K. M. HOFFMEISTER   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

New gene functions in megakaryopoiesis and platelet formation

(2011) Christian Gieger et al.   NATURE

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

(2011) Domagoj Vucic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Impact of Preoperative Thrombocytosis on the Survival of Patients with Primary Colorectal Cancer

(2011) Kazuhito Sasaki et al.   WORLD JOURNAL OF SURGERY

P-selectin-dependent platelet aggregation and apoptosis may explain the decrease in platelet count during Helicobacter pylori infection

(2010) J.-J. Yeh et al.   BLOOD

Autoimmunity and the Clearance of Dead Cells

(2010) Shigekazu Nagata et al.   CELL

Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development

(2010) P N Kelly et al.   CELL DEATH AND DIFFERENTIATION

Thrombocytopenia Exacerbates Cholestasis-Induced Liver Fibrosis in Mice

(2010) Takahiro Kodama et al.   GASTROENTEROLOGY

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

(2010) Wyndham H Wilson et al.   LANCET ONCOLOGY

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

(2010) D. Ren et al.   SCIENCE

Platelet apoptosis resistance and increased CXCR4 expression in pediatric patients with chronic immune thrombocytopenic purpura

(2010) Jiaan-Der Wang et al.   THROMBOSIS RESEARCH

Use of additive solutions and pathogen inactivation treatment of platelet components in a regional blood center: impact on patient outcomes and component utilization during a 3-year period

(2010) Jean-Pierre Cazenave et al.   TRANSFUSION

Platelet apoptosis and activation in platelet concentrates stored for up to 12 days in plasma or additive solution

(2010) P. Cookson et al.   TRANSFUSION MEDICINE

Role of sialic acid for platelet life span: exposure of  -galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes

(2009) A. L. Sorensen et al.   BLOOD

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function

(2009) S. M. Schoenwaelder et al.   BLOOD

Mechanisms of resveratrol-induced platelet apoptosis

(2009) K. H. Lin et al.   CARDIOVASCULAR RESEARCH

Apoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases

(2009) M F van Delft et al.   CELL DEATH AND DIFFERENTIATION

The glycoprotein Ibα-von Willebrand factor interaction induces platelet apoptosis

(2009) S. LI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

XIAP discriminates between type I and type II FAS-induced apoptosis

(2009) Philipp J. Jost et al.   NATURE

Dual roles for hepatic lectin receptors in the clearance of chilled platelets

(2009) Viktoria Rumjantseva et al.   NATURE MEDICINE

Comparison of the relative activities of inducing platelet apoptosis stimulated by various platelet-activating agents

(2009) Kuan H. Lin et al.   PLATELETS

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Thrombin induces activation and translocation of Bid, Bax and Bak to the mitochondria in human platelets

(2008) J. J. LOPEZ et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Markers of platelet activation and apoptosis during storage of apheresis- and buffy coat-derived platelet concentrates for 7 days

(2008) Abdul-Majeed Albanyan et al.   TRANSFUSION

Preoperative Platelet Count and Survival Prognosis in Resected Pancreatic Ductal Adenocarcinoma

(2008) Ismael Domínguez et al.   WORLD JOURNAL OF SURGERY

Prognostic impact of thrombocytosis in resectable non-small cell lung cancer

(2008) M. Tomita et al.   Interactive Cardiovascular and Thoracic Surgery