标题
The Function of V-ATPases in Cancer
作者
关键词
-
出版物
PHYSIOLOGICAL REVIEWS
Volume 96, Issue 3, Pages 1071-1091
出版商
American Physiological Society
发表日期
2016-06-23
DOI
10.1152/physrev.00035.2015
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- DrosophilaMitf regulates the V-ATPase and the lysosomal-autophagic pathway
- (2016) Valentina Bouché et al. Autophagy
- Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis inDrosophila melanogaster
- (2016) Emiliana Tognon et al. Autophagy
- ZT-25, a new vacuolar H+-ATPase inhibitor, induces apoptosis and protective autophagy through ROS generation in HepG2 cells
- (2016) Yapeng Lu et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Time to use a dose of Chloroquine as an adjuvant to anti-cancer chemotherapies
- (2016) Steve Pascolo EUROPEAN JOURNAL OF PHARMACOLOGY
- Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells
- (2015) Dannie Bernard et al. APOPTOSIS
- The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flux via interaction with the vacuolar ATPase
- (2015) Sim Namkoong et al. Autophagy
- Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion
- (2015) Caroline Mauvezin et al. Autophagy
- Notch signaling: An emerging therapeutic target for cancer treatment
- (2015) Xun Yuan et al. CANCER LETTERS
- The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator
- (2015) Brandon Faubert et al. CANCER LETTERS
- Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer
- (2015) L. S. Schneider et al. CANCER RESEARCH
- Expression and role of V1A subunit of V-ATPases in gastric cancer cells
- (2015) Pengfei Liu et al. International Journal of Clinical Oncology
- Autophagic flux promotes cisplatin resistance in human ovarian carcinoma cells through ATP-mediated lysosomal function
- (2015) LIWEI MA et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Vacuolar-ATPase-mediated intracellular sequestration of ellipticine contributes to drug resistance in neuroblastoma cells
- (2015) JAN HRABETA et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly
- (2015) Laura A. Stransky et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Affinity Purification and Structural Features of the Yeast Vacuolar ATPase VoMembrane Sector
- (2015) Sergio Couoh-Cardel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1
- (2015) T. Zhang et al. JOURNAL OF CELL SCIENCE
- Notch-1 Promotes Stemness and Epithelial to Mesenchymal Transition in Colorectal Cancer
- (2015) Alexander W. Fender et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Notch Reporter Activity in Breast Cancer Cell Lines Identifies a Subset of Cells with Stem Cell Activity
- (2015) R. C. D'Angelo et al. MOLECULAR CANCER THERAPEUTICS
- Electron cryomicroscopy observation of rotational states in a eukaryotic V-ATPase
- (2015) Jianhua Zhao et al. NATURE
- TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells
- (2015) F Lozupone et al. ONCOGENE
- pH Gradient Reversal: An Emerging Hallmark of Cancers
- (2015) Mohit Sharma et al. Recent Patents on Anti-Cancer Drug Discovery
- Differential regulation of mTORC1 by leucine and glutamine
- (2015) J. L. Jewell et al. SCIENCE
- Recent Insights into the Structure, Regulation, and Function of the V-ATPases
- (2015) Kristina Cotter et al. TRENDS IN BIOCHEMICAL SCIENCES
- Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification
- (2015) Caroline Mauvezin et al. Nature Communications
- AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer
- (2015) Shao-hua Fan et al. Oncotarget
- The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma
- (2015) Andrea Di Cristofori et al. Oncotarget
- Vacuolar ATPase 'a2' isoform exhibits distinct cell surface accumulation and modulates matrix metalloproteinase activity in ovarian cancer
- (2015) Arpita Kulshrestha et al. Oncotarget
- DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation
- (2015) Monica Faronato et al. Oncotarget
- Targeting RTK Signaling Pathways in Cancer
- (2015) Tarik Regad Cancers
- Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis
- (2015) Regina M. Graham et al. Oncotarget
- Acid-Mediated Tumor Proteolysis: Contribution of Cysteine Cathepsins
- (2015) Jennifer M Rothberg et al. NEOPLASIA
- Eukaryotic V-ATPase: Novel structural findings and functional insights
- (2014) Vladimir Marshansky et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism
- (2014) Chen-Song Zhang et al. Cell Metabolism
- Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis
- (2014) José A. Martina et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- A founder mutation in theTCIRG1gene causes osteopetrosis in the Ashkenazi Jewish population
- (2014) S.L. Anderson et al. CLINICAL GENETICS
- Activity of Plasma Membrane V-ATPases Is Critical for the Invasion of MDA-MB231 Breast Cancer Cells
- (2014) Kristina Cotter et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Orexin/Hypocretin Activates mTOR Complex 1 (mTORC1) via an Erk/Akt-independent and Calcium-stimulated Lysosome v-ATPase Pathway
- (2014) Zhiqiang Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- V-ATPase Inhibition Regulates Anoikis Resistance and Metastasis of Cancer Cells
- (2014) C. M. Schempp et al. MOLECULAR CANCER THERAPEUTICS
- Cytosolic pH Regulates Cell Growth through Distinct GTPases, Arf1 and Gtr1, to Promote Ras/PKA and TORC1 Activity
- (2014) Reinhard Dechant et al. MOLECULAR CELL
- Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase
- (2014) Alexandre Gidon et al. Nature Chemical Biology
- Atp6v1c1 May Regulate Filament Actin Arrangement in Breast Cancer Cells
- (2014) Shengmei Feng et al. PLoS One
- Impairment of Lysosomal Activity as a Therapeutic Modality Targeting Cancer Stem Cells of Embryonal Rhabdomyosarcoma Cell Line RD
- (2014) Manuela Salerno et al. PLoS One
- LASS2/TMSG1 inhibits growth and invasion of breast cancer cell in vitro through regulation of vacuolar ATPase activity
- (2014) Fang Mei et al. TUMOR BIOLOGY
- V-ATPase/mTOR Signaling Regulates Megalin-Mediated Apical Endocytosis
- (2014) Eva Maria Gleixner et al. Cell Reports
- Rabconnectin-3a Regulates Vesicle Endocytosis and Canonical Wnt Signaling in Zebrafish Neural Crest Migration
- (2014) Adam M. Tuttle et al. PLOS BIOLOGY
- VMA21 deficiency prevents vacuolar ATPase assembly and causes autophagic vacuolar myopathy
- (2013) Nivetha Ramachandran et al. ACTA NEUROPATHOLOGICA
- Regulation of endothelial signaling and migration by v-ATPase
- (2013) Sebastian Rath et al. ANGIOGENESIS
- V-ATPase is a candidate therapeutic target for Ewing sarcoma
- (2013) Sofia Avnet et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- The expression of V-ATPase is associated with drug resistance and pathology of non-small-cell lung cancer
- (2013) Qiang Lu et al. Diagnostic Pathology
- Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium
- (2013) A. G. Petzoldt et al. Disease Models & Mechanisms
- Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes
- (2013) Vladimira Horova et al. FEBS Journal
- Silencing of Atp6v1c1 Prevents Breast Cancer Growth and Bone Metastasis
- (2013) Shengmei Feng et al. International Journal of Biological Sciences
- Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer
- (2013) An Hendrix et al. INTERNATIONAL JOURNAL OF CANCER
- V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activationin vivo
- (2013) Rebekka Kubisch et al. INTERNATIONAL JOURNAL OF CANCER
- Regulated Assembly of Vacuolar ATPase Is Increased during Cluster Disruption-induced Maturation of Dendritic Cells through a Phosphatidylinositol 3-Kinase/mTOR-dependent Pathway
- (2013) Rachel Liberman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Function of Vacuolar ATPase (V-ATPase) a Subunit Isoforms in Invasiveness of MCF10a and MCF10CA1a Human Breast Cancer Cells
- (2013) Joseph Capecci et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Silencing of LASS2/TMSG1 enhances invasion and metastasis capacity of prostate cancer cell
- (2013) Xiaoyan Xu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells
- (2013) Georgios Kallifatidis et al. Marine Drugs
- V-ATPase inhibition overcomes trastuzumab resistance in breast cancer
- (2013) Karin von Schwarzenberg et al. Molecular Oncology
- Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling
- (2013) Francis Kobia et al. Molecular Oncology
- HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H+ ATPase
- (2013) F M Fogarty et al. ONCOGENE
- Regulation of Luminal Acidification by the V-ATPase
- (2013) Sylvie Breton et al. PHYSIOLOGY
- Impaired endolysosomal function disrupts Notch signalling in optic nerve astrocytes
- (2013) Mallika Valapala et al. Nature Communications
- Investigating Mechanisms of Alkalinization for Reducing Primary Breast Tumor Invasion
- (2013) Ian F. Robey et al. Biomed Research International
- pH sensing and regulation in cancer
- (2013) Mehdi Damaghi et al. Frontiers in Physiology
- The (pro)renin receptor ((P)RR) can act as a repressor of Wnt signalling
- (2012) Sarah M. Bernhard et al. BIOCHEMICAL PHARMACOLOGY
- The V-ATPase-Inhibitor Archazolid Abrogates Tumor Metastasis via Inhibition of Endocytic Activation of the Rho-GTPase Rac1
- (2012) R. M. Wiedmann et al. CANCER RESEARCH
- Expression and functional role of vacuolar H+-ATPase in human hepatocellular carcinoma
- (2012) J. Xu et al. CARCINOGENESIS
- Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
- (2012) Liron Bar-Peled et al. CELL
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Targeting Reversible Disassembly as a Mechanism of Controlling V-ATPase Activity
- (2012) Patricia M. Kane CURRENT PROTEIN & PEPTIDE SCIENCE
- ABCG2/V-ATPase was associated with the drug resistance and tumor metastasis of esophageal squamous cancer cells
- (2012) Lijun Huang et al. Diagnostic Pathology
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
- (2012) Carmine Settembre et al. EMBO JOURNAL
- The renal v-ATPase a4 subunit is expressed in specific subtypes of human gliomas
- (2012) Vincent Gleize et al. GLIA
- Inhibitors of vacuolar ATPase proton pumps inhibit human prostate cancer cell invasion and prostate-specific antigen expression and secretion
- (2012) Vera Michel et al. INTERNATIONAL JOURNAL OF CANCER
- Epidermal Growth Factor-induced Vacuolar (H+)-ATPase Assembly
- (2012) Yanqing Xu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mode of Cell Death Induction by Pharmacological Vacuolar H+-ATPase (V-ATPase) Inhibition
- (2012) Karin von Schwarzenberg et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Silencing of a novel tumor metastasis suppressor gene LASS2/TMSG1 promotes invasion of prostate cancer cell in vitro through increase of vacuolar ATPase activity
- (2012) Xiaoyan Xu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Rabconnectin3 Promotes Stable Activity of the H+ Pump on Synaptic Vesicles in Hair Cells
- (2012) Z. Einhorn et al. JOURNAL OF NEUROSCIENCE
- Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival
- (2012) Alejo Efeyan et al. NATURE
- A human genome-wide screen for regulators of clathrin-coated vesicle formation reveals an unexpected role for the V-ATPase
- (2012) Patrycja Kozik et al. NATURE CELL BIOLOGY
- LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump
- (2012) S Fan et al. ONCOGENE
- Cancer-associated lysosomal changes: friends or foes?
- (2012) T Kallunki et al. ONCOGENE
- Role of Ion Channels and Transporters in Cell Migration
- (2012) Albrecht Schwab et al. PHYSIOLOGICAL REVIEWS
- V-ATPase engagement in autophagic processes
- (2011) Dalibor Mijaljica et al. Autophagy
- Receptor Tyrosine Kinases and Targeted Cancer Therapeutics
- (2011) Kenji Takeuchi et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Immunohistochemical localization of C1 subunit of V-ATPase (ATPase C1) in oral squamous cell cancer and normal oral mucosa
- (2011) A García-García et al. BIOTECHNIC & HISTOCHEMISTRY
- Regulation of TFEB and V-ATPases by mTORC1
- (2011) Samuel Peña-Llopis et al. EMBO JOURNAL
- Effects of diphyllin as a novel V-ATPase inhibitor on gastric adenocarcinoma
- (2011) Weidong Shen et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Enhanced Lysosomal Activity Is Involved in Bax Inhibitor-1-induced Regulation of the Endoplasmic Reticulum (ER) Stress Response and Cell Death against ER Stress
- (2011) Geum-Hwa Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Endosomal Accumulation of the Activated Epidermal Growth Factor Receptor (EGFR) Induces Apoptosis
- (2011) Jamie S. Rush et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Definition of Membrane Topology and Identification of Residues Important for Transport in Subunit a of the Vacuolar ATPase
- (2011) Masashi Toei et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The V-ATPase a3 subunit mutation R740S is dominant negative and results in osteopetrosis in mice
- (2011) Noelle Ochotny et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Prorenin Receptor Is Essential for Podocyte Autophagy and Survival
- (2011) F. Riediger et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer
- (2011) Chuhan Chung et al. LABORATORY INVESTIGATION
- The a3 Isoform Vacuolar Type H+-ATPase Promotes Distant Metastasis in the Mouse B16 Melanoma Cells
- (2011) T. Nishisho et al. MOLECULAR CANCER RESEARCH
- The Role of Autophagy in Cancer: Therapeutic Implications
- (2011) Z. J. Yang et al. MOLECULAR CANCER THERAPEUTICS
- Interfering with pH regulation in tumours as a therapeutic strategy
- (2011) Dario Neri et al. NATURE REVIEWS DRUG DISCOVERY
- mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
- (2011) R. Zoncu et al. SCIENCE
- Proteolytic networks in cancer
- (2011) Steven D. Mason et al. TRENDS IN CELL BIOLOGY
- Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer
- (2010) Tom Donnem et al. CANCER
- Measurement of ATP6V1C1 expression in brush cytology samples as a diagnostic and prognostic marker in oral squamous cell carcinoma
- (2010) Mario Pérez-Sayáns et al. CANCER BIOLOGY & THERAPY
- Influenza A virus-induced early activation of ERK and PI3K mediates V-ATPase-dependent intracellular pH change required for fusion
- (2010) Henju Marjuki et al. CELLULAR MICROBIOLOGY
- The (Pro)renin Receptor/ATP6AP2 is Essential for Vacuolar H + -ATPase Assembly in Murine Cardiomyocytes
- (2010) Kenichiro Kinouchi et al. CIRCULATION RESEARCH
- Regulation of Frizzled-Dependent Planar Polarity Signaling by a V-ATPase Subunit
- (2010) Tobias Hermle et al. CURRENT BIOLOGY
- Wnt/Frizzled Signaling Requires dPRR, the Drosophila Homolog of the Prorenin Receptor
- (2010) Tina Buechling et al. CURRENT BIOLOGY
- The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor
- (2010) T. Vaccari et al. DEVELOPMENT
- PKA Regulates Vacuolar H+-ATPase Localization and Activity via Direct Phosphorylation of the A Subunit in Kidney Cells
- (2010) Rodrigo Alzamora et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rabconnectin-3 Is a Functional Regulator of Mammalian Notch Signaling
- (2010) Nilay Sethi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The role of autophagy in anticancer therapy: promises and uncertainties
- (2010) M. P. Tschan et al. JOURNAL OF INTERNAL MEDICINE
- V-ATPase Membrane Sector Associates with Synaptobrevin to Modulate Neurotransmitter Release
- (2010) Jérôme Di Giovanni et al. NEURON
- Requirement of Prorenin Receptor and Vacuolar H+-ATPase-Mediated Acidification for Wnt Signaling
- (2010) C.-M. Cruciat et al. SCIENCE
- The H+ Vacuolar ATPase Maintains Neural Stem Cells in the Developing Mouse Cortex
- (2010) Christian Lange et al. STEM CELLS AND DEVELOPMENT
- Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells
- (2010) M L Marino et al. Cell Death & Disease
- Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells
- (2009) Haiyan You et al. CANCER LETTERS
- Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases
- (2009) I. F. Robey et al. CANCER RESEARCH
- Autophagy Suppresses Tumorigenesis through Elimination of p62
- (2009) Robin Mathew et al. CELL
- The Vacuolar Proton Pump, V-ATPase, Is Required for Notch Signaling and Endosomal Trafficking in Drosophila
- (2009) Yan Yan et al. DEVELOPMENTAL CELL
- pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity
- (2009) Angelo De Milito et al. INTERNATIONAL JOURNAL OF CANCER
- Heme-binding Protein HRG-1 Is Induced by Insulin-like Growth Factor I and Associates with the Vacuolar H+-ATPase to Control Endosomal pH and Receptor Trafficking
- (2009) Katie M. O'Callaghan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Function of a Subunit Isoforms of the V-ATPase in pH Homeostasis andin VitroInvasion of MDA-MB231 Human Breast Cancer Cells
- (2009) Ayana Hinton et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protons make tumor cells move like clockwork
- (2009) Christian Stock et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo
- (2008) Francesca Peri et al. CELL
- Analysis of the Membrane Topology of Transmembrane Segments in the C-terminal Hydrophobic Domain of the Yeast Vacuolar ATPase Subunit a (Vph1p) by Chemical Modification
- (2008) Yanru Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure of the Yeast Vacuolar ATPase
- (2008) Zhenyu Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Additional MDA-MB-231 breast cancer cell matrix metalloproteinases promote invasiveness
- (2008) Luca Hegedüs et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Biochemical and functional characterization of the actin-binding activity of the B subunit of yeast vacuolar H+-ATPase
- (2008) J. Zuo et al. JOURNAL OF EXPERIMENTAL BIOLOGY
- Regulation of TORC1 by Rag GTPases in nutrient response
- (2008) Eunjung Kim et al. NATURE CELL BIOLOGY
- The proton pump inhibitor inhibits cell growth and induces apoptosis in human hepatoblastoma
- (2008) Toshiya Morimura et al. PEDIATRIC SURGERY INTERNATIONAL
- The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
- (2008) Y. Sancak et al. SCIENCE
- Intracellular pH regulation in oral squamous cell carcinoma is mediated by increased V-ATPase activity via over-expression of the ATP6V1C1 gene
- (2007) Eva María Otero-Rey et al. ORAL ONCOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search