期刊
NATURE CHEMICAL BIOLOGY
卷 10, 期 9, 页码 707-709出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.1589
关键词
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资金
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the US National Institutes of Health (NIH) [R01 DK087688, R01 DK102495, P01 DK11794, R01 DK08184, F32 DK097889]
- Cellular Physiology Core of the 'Pittsburgh Kidney Research Center' [P30 DK079307]
The PTH receptor is to our knowledge one of the first G protein-coupled receptor (GPCR) found to sustain cAMP signaling after internalization of the ligand-receptor complex in endosomes. This unexpected model is adding a new dimension on how we think about GPCR signaling, but its mechanism is incompletely understood. We report here that endosomal acidification mediated by the PKA action on the v-ATPase provides a negative feedback mechanism by which endosomal receptor signaling is turned off.
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