Article
Cell Biology
Zijia Wang, Haofeng Xiong, Yijie Zuo, Shujun Hu, Chao Zhu, Anjie Min
Summary: PSMC2 was found to be significantly upregulated in oral squamous cell carcinoma (OSCC) tissues compared to normal tissues, and its knockdown suppressed cell proliferation and migration while promoting apoptosis of OSCC cells. The effects of PSMC2 on OSCC progression may be mediated through its influence on pro-apoptotic protein expression and apoptosis pathways. Targeting PSMC2 could be a promising strategy for OSCC treatment.
Article
Biochemistry & Molecular Biology
Xinyu Zhang, Yong Han, Shuli Liu, Bing Guo, Shengming Xu, Yue He, Liu Liu
Summary: This study revealed the overexpression of USP30 in OSCC and demonstrated its role in cell viability and glutamine consumption through deubiquitylation activity. The utilization of USP30 inhibitor MF-094 loaded in nanoparticles effectively inhibited cell viability and glutamine consumption of OSCC, providing a novel strategy for treating OSCC.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Cell Biology
Mariko Tsunoda, Mai Fukasawa, Anna Nishihara, Leo Takada, Masatake Asano
Summary: The study demonstrates that the proteasome inhibitor MG132 enhances IL-8 secretion, regulated by the transcription factor AP-1. The research investigates the combination of AP-1 family proteins contributing to MG132-driven IL-8 secretion.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Pathology
Smiljana Spasic, Oleksandr N. Kryvenko, Darcy A. Kerr, Gunnlaugur P. Nielsen, Carmen Gomez-Fernandez, Andrew E. Rosenberg
Summary: PSH within bone is rare and can be mistaken for SCC, especially in patients with a history of SCC. It often occurs in the mandible and can complicate severe osteomyelitis. Patients with PSH should undergo regular follow-up to monitor any changes, especially those with previous SCC.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Review
Medicine, General & Internal
Nai-Wen Su, Yu-Jen Chen
Summary: Metronomic therapy is a low-dose, repeated treatment approach for cancer that targets antiangiogenesis and immunomodulation mechanisms, showing comparative efficacy to traditional chemotherapy but with reduced side effects. In the treatment of oral cavity squamous cell carcinoma and other cancers, metronomic therapy has demonstrated promising results.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Leonardo de Oliveira da Rocha, Bruno Solano de Freitas Souza, Ricardo Della Coletta, Daniel W. Lambert, Clarissa A. Gurgel Rocha
Summary: Cell-in-cell (CIC) structures contribute to tumor aggressiveness and poor prognosis in oral squamous cell carcinoma (OSCC). In this study, spheroids obtained from OSCC and cancer-associated fibroblast (CAF) lines were used to investigate CIC structures. The spheroids showed the morphological aspects of the tumor microenvironment and CIC structures were found in both homotypic and heterotypic groups, predominantly in the proliferative zone of mixed spheroids. Complex cannibalism events were also observed. This model has the potential for further studies on CIC morphology, formation, and its relationship with tumor prognosis.
Review
Oncology
Leonardo Di Gennaro, Raimondo De Cristofaro, Antonietta Ferretti, Maria Basso, Claudia Riccio, Massimo Cordaro, Carlo Lajolo
Summary: This review discusses the relationship between oral squamous cell carcinoma (OSCC) and venous thromboembolism (VTE). VTE has a significant impact on the mortality rate of cancer patients, and the thrombotic risk in OSCC patients has not been extensively studied, leading to insufficient prevention measures and affecting the effectiveness of oncologic treatment.
Article
Biochemistry & Molecular Biology
Xun Chen, Sufang Kuang, Yi He, Hongyu Li, Chen Yi, Yiming Li, Chao Wang, Guanhui Chen, Shangwu Chen, Dongsheng Yu
Summary: Metabolic reprogramming in tumors plays a crucial role in tumor development, progression, and drug resistance. Early metabolic intervention may prevent the development of drug resistance. Comparative metabolomics analysis can identify metabolic targets and biomarkers for tumor therapy by examining differential metabolic responses between tumor cells and normal cells.
Article
Chemistry, Medicinal
Guya Diletta Marconi, Ylenia Della Rocca, Luigia Fonticoli, Francesco Melfi, Thangavelu Soundara Rajan, Simone Carradori, Jacopo Pizzicannella, Oriana Trubiani, Francesca Diomede
Summary: The study aims to evaluate the role of c-Myc in the pathogenesis of oral squamous cell carcinoma (OSCC). The results show the vital role of c-Myc in tumor growth and cell survival/proliferation, along with the inhibitory effect of Doxorubicin (Doxo) on c-Myc signaling pathway.
Article
Biochemistry & Molecular Biology
Rong Jia, Xiaoxuan Che, Jun Jia, Jihua Guo
Summary: The study revealed that FOXM1a reduces cell proliferation and tumor formation in oral squamous cell carcinoma, regulated by exon 9 splicing and hnRNP C. This discovery uncovers a novel regulatory mechanism of oncogene FOXM1 expression in OSCC.
Review
Oncology
Leonardo de Oliveira Siquara da Rocha, Bruno Solano de Freitas Souza, Daniel W. Lambert, Clarissa de Araujo Gurgel Rocha
Summary: Cell-in-cell structures are common in tumors, including oral squamous cell carcinoma. Cell-in-cell events in oral squamous cell carcinoma are associated with tumor aggressiveness, metastasis, and therapeutic resistance. The lack of standard terminology makes it difficult to classify and understand the behavior and impacts of these structures. Understanding the link between cell-in-cell structures and more aggressive behavior in oral squamous cell carcinoma is crucial for developing effective therapeutic strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Jian Chen, Fan Zhang, Mengmeng Hua, Xiaobin Song, Shaohua Liu, Zuoqing Dong
Summary: This study demonstrated a significant association between intratumoral lymphatic vessel density (ILVD) and increased lymphatic metastasis, tumor recurrence, and reduced disease-specific survival in patients with oral squamous cell carcinoma. ILVD could be considered as an indicator for predicting the prognosis of OSCC.
Review
Biochemistry & Molecular Biology
Heinrich Botha, Camile S. Farah, Kendrick Koo, Nicola Cirillo, Michael McCullough, Rita Paolini, Antonio Celentano
Summary: Research shows that in oral squamous cell carcinoma, glucose transporter 1 (GLUT-1) and GLUT-3 expression levels are correlated with tumor stage, treatment resistance, and poor prognosis. Other glucose transporters (GLUTs) are relatively understudied and may have the potential to improve patient care with further analysis.
Article
Microbiology
Wei Wei, Jia Li, Xin Shen, Jinglu Lyu, Caixia Yan, Boyu Tang, Wenjuan Ma, Huixu Xie, Lei Zhao, Lei Cheng, Ye Deng, Yan Li
Summary: Periodontitis promotes the development of OSCC by altering the oral bacterial community and tumor immune microenvironment.
Article
Biochemistry & Molecular Biology
Chia-Huei Lee, Yu-Hsin Tsao, Yui-Ping Weng, I-Ching Wang, Yao-Ping Chen, Pin-Feng Hung
Summary: The herbal medicine perilla leaf extract (PLE) has been found to inhibit the viability of oral squamous cell carcinoma (OSCC) cells. The main phenols in PLE, caffeic acid (CA) and rosmarinic acid (RA), were shown to reduce OSCC cell viability in a dose-dependent manner. In addition, chronic treatment with CA and RA increased the sensitivity of OSCC cells to the EGFR tyrosine kinase inhibitor gefitinib and effectively suppressed interleukin-1 beta secretion. These findings suggest that perilla phenols can be used as adjuvant therapies to improve the efficacy of chemotherapy and EGFR-targeted therapy in OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Alejandro Lorenzo-Pouso, Susana B. Bravo, Javier Carballo, Maria del Pilar Chantada-Vazquez, Jose Bagan, Leticia Bagan, Cintia M. Chamorro-Petronacci, Mercedes Conde-Amboage, Rafael Lopez-Lopez, Abel Garcia-Garcia, Mario Perez-Sayans
Summary: This study investigated the salivary proteome in MRONJ patients and identified differentially expressed proteins. Three prioritized proteins were identified, which may serve as a potential biomarker panel for the prediction or diagnosis of MRONJ.
Review
Dentistry, Oral Surgery & Medicine
Luis Chauca-Bajana, Byron Velasquez-Ron, Inmaculada Tomas-Carmona, Fabio Camacho-Alonso, Alba Perez-Jardon, Mario Perez-Sayans
Summary: The study evaluated the efficacy of mesenchymal stem cells (MSCs) in regenerating periodontal bone defects in animal models. The findings indicate that MSCs have a greater capacity for tissue regeneration in root cementum compared to other regenerative materials.
Article
Dentistry, Oral Surgery & Medicine
Marta Vilar-Villanueva, Jose Manuel Somoza-Martin, Andres Blanco-Carrion, Abel Garcia-Garcia, Tamara Garcia-Carnicero, Xabier Marichalar-Mendia, Mercedes Gallas-Torreira, Pilar Gandara-Vila
Summary: The main objective of this study was to assess the effectiveness of CO2 laser vaporization treatment for oral leukoplakia and determine the factors that may affect lesion recurrence. A retrospective study was conducted, and it was found that there was a statistically significant association between the margin and lesion recurrence. Maintaining a safety margin of at least 3mm during CO2 laser vaporization is a key factor in preventing recurrence.
Article
Dentistry, Oral Surgery & Medicine
Gisela C. Camolesi, Jose M. Somoza-Martin, Maria D. Reboiras-Lopez, Fabio Camacho-Alonso, Andres Blanco-Carrion, Mario Perez-Sayans
Summary: This randomized clinical trial aimed to evaluate the effect of diode laser photobiomodulation (PBM) on post-surgical healing, inflammation, and implant stability. The results showed that PBM+ group had higher healing index and lower inflammation rate, indicating that diode laser PBM can effectively reduce inflammation and improve early healing.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Martin Santamarina-Garcia, Jenifer Brea-Iglesias, Jesper Bertram Bramsen, Mar Fuentes-Losada, Francisco Javier Caneiro-Gomez, Jose Angel Vazquez-Bueno, Hector Lazare-Iglesias, Natalia Fernandez-Diaz, Laura Sanchez-Rivadulla, Yoel Z. Betancor, Miriam Ferreiro-Pantin, Pablo Conesa-Zamora, Jose Ramon Antunez-Lopez, Masahito Kawazu, Manel Esteller, Claus Lindbjerg Andersen, Jose M. C. Tubio, Rafael Lopez-Lopez, Juan Ruiz-Banobre
Summary: Deficient DNA MMR activity leads to tumors with hypermutator phenotype called microsatellite instability (MSI). MSI has become an important predictive biomarker for anti-PD-1 therapies in various tumor types. In this study, we developed and validated MSIMEP, a computational tool for predicting MSI status from microarray DNA methylation tumor profiles of colorectal cancer samples. We demonstrated the high performance of MSIMEP in predicting MSI in different colorectal cancer cohorts and tested its consistency in other tumor types. The MSIMEP models showed better performance compared to a MLH1 promoter methylation-based model in colorectal cancer.
Review
Biology
Alejandro I. Lorenzo-Pouso, Fabio Franca-Vieira e Silva, Alba Perez-Jardon, Cintia M. Chamorro-Petronacci, Monica G. Oliveira-Alves, Oscar Alvarez-Calderon-Iglesias, Vito Carlo Alberto Caponio, Morena Pinti, Vittoria Perrotti, Mario Perez-Sayans
Summary: Oral squamous cell carcinoma (OSCC) has a low survival rate and novel prognostic biomarkers are needed. Our study found that low expression of the protein E-cadherin is associated with poor prognosis in OSCC patients. Assessing E-cadherin during routine histopathology diagnoses could be a promising prognostic tool.
Article
Dentistry, Oral Surgery & Medicine
Mario Perez-Sayans, Cintia M. Chamorro-Petronacci, Susana B. Bravo, Maria E. Padin-Iruegas, Esteban Guitian-Fernandez, Francisco Barros-Angueira, Rita Quintas-Rey, Abel Garcia-Garcia
Summary: This study describes the genetic variants associated with the development of head and neck cancer (HNC) and validates their molecular implications. A family of 3 generations, where 3 members had developed HNC, was observed. It was found that 6 out of 13 members carried the same mutation of CYP26B1, and lower levels of all-trans retinoic acid (atRA) were confirmed in their plasma.
Article
Medicine, General & Internal
Sofia Soler-Alcaraz, Yolanda Guerrero-Sanchez, Mario Perez-Sayans, Juan Carlos Bernabeu-Mira, David Penarrocha-Oltra, Fabio Camacho-Alonso
Summary: The research aimed to compare the influence of different drilling methods on implant success and osseointegration process. The study found no significant differences in the trabecular architecture between biological and conventional drilling techniques. Therefore, the drilling technique does not affect the success of the procedure or the osseointegration process.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Juan Carlos Bernabeu-Mira, Maria Penarrocha-Diago, Jose Vina-Almunia, Francisco Romero-Gavilan, Mario Perez-Sayans, David Penarrocha-Oltra
Summary: The objective of this study was to analyze the influence of 3-mm high abutments with different shapes (cylindrical abutment vs. wide abutment) on marginal bone-level changes. The results showed that the cylindrical abutment group exhibited less bone remodeling and bone loss than the wide abutment group, as well as reduced bleeding on probing. Therefore, abutment shape has a significant influence on marginal bone-level changes during the first 12 months.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Luis Alberto Chauca Bajana, Luis Campos Lascano, Lourdes Jaramillo Castellon, Carlos Carpio Cevallos, Gabriela Cevallos-Pozo, Byron Velasquez Ron, Fabio Franca Vieira e Silva, Mario Perez-Sayans
Summary: This study aimed to determine the prevalence of burnout syndrome and its associated factors in the integral clinic of the Dentistry Pilot School. The results showed high levels of emotional exhaustion and depersonalization, as well as low perception of personal fulfillment among the participants. Additionally, burnout syndrome was found to be significantly related to marital status, work experience, and various physical symptoms.
INTERNATIONAL JOURNAL OF DENTISTRY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Ana Munoz-Salgado, Fabio Franca Vieira e Silva, Maria Elena Padin-Iruegas, Gisela Cristina Vianna Camolesi, Wilber Edison Bernaola-Paredes, Henrique Rocha Mazorchi Veronese, Miria de Andrade Celestino, William Jose Silva Filho, Alejandro Lorenzo-Pouso, Mario Perez-Sayans
Summary: This study analyzed the effectiveness of L-PRF in the treatment of ONJ through a systematic review and meta-analysis. The results showed that L-PRF achieved a 94.3% complete resolution rate and demonstrated high reliability.
MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Shakiba Gholami, Cintia Chamorro-Petronacci, Mario Perez-Sayans, Jose Suarez Penaranda, Adhemar Longatto-Filho, Fatima Baltazar, Julieta Afonso
Summary: Oral potentially malignant disorders (OPMD) are associated with an increased risk of oral squamous cell carcinoma (OSCC), which is characterized by aggressive features and poor prognosis. Cancer cells can reprogram their metabolism through hypoxia-inducible factor (HIF) signaling, leading to upregulation of glycometabolism-related biomarkers. This study aimed to evaluate the expression of HIF targets in OPMD and OSCC samples and identify potential correlations with clinicopathological features and prognosis.
JOURNAL OF APPLIED ORAL SCIENCE
(2023)
Article
Oncology
Samuel Rodriguez-Zorrilla, Alejandro I. Lorenzo-Pouso, Stefano Fais, Maria A. Logozzi, Davide Mizzoni, Rossella Di Raimo, Alessandro Giuliani, Abel Garcia-Garcia, Alba Perez-Jardon, Karem L. Ortega, Angel Martinez-Gonzalez, Mario Perez-Sayans
Summary: This study found that exosomal profiles can be used as a tool for early detection of relapse and long-term outcomes in oral squamous cell carcinoma (OSCC) patients undergoing conventional therapy. The study observed a significant reduction in exosome levels after surgery and higher exosome concentrations in patients experiencing relapse. Lower exosome levels before surgery were correlated with better disease-free survival.