Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer's Disease

Curcumin/Melatonin Hybrid 5-(4-Hydroxy-phenyl)-3-oxo-pentanoic Acid [2-(5-Methoxy-1H-indol-3-yl)-ethyl]-amide Ameliorates AD-Like Pathology in the APP/PS1 Mouse Model

(2015) Gorka Gerenu et al.   ACS Chemical Neuroscience

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Development of a Natural-Product-Derived Chemical Toolbox for Modulation of Protein Function

(2014) Stefano Rizzo et al.   CHEMICAL REVIEWS

Polypharmacology: the rise of multitarget drugs over combination therapies

(2014) Michela Rosini   Future Medicinal Chemistry

Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents

(2014) Elisabet Viayna et al.   JOURNAL OF MEDICINAL CHEMISTRY

Polypharmacology: Challenges and Opportunities in Drug Discovery

(2014) Andrew Anighoro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects

(2014) Eugenie Nepovimova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Keap1 Cysteine 288 as a Potential Target for Diallyl Trisulfide-Induced Nrf2 Activation

(2014) Sanghyun Kim et al.   PLoS One

Abeta, oxidative stress in Alzheimer disease: Evidence based on proteomics studies

(2013) Aaron M. Swomley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Bivalent Ligand Approach as a Tool for Improving the in vitro Anti-Alzheimer Multitarget Profile of Dimebon

(2013) Michela Rosini et al.   ChemMedChem

Amyloid β, Glutamate, Excitotoxicity in Alzheimer's Disease: Are We on the Right Track?

(2013) Zaira Esposito et al.   CNS Neuroscience & Therapeutics

Protein Folding and Aggregation into Amyloid: The Interference by Natural Phenolic Compounds

(2013) Massimo Stefani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative Stress in Alzheimer’s Disease: Are We Connecting the Dots?

(2013) Michela Rosini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Zyxin is a novel target for beta-amyloid peptide: characterization of its role in Alzheimer's pathogenesis

(2013) Cristina Lanni et al.   JOURNAL OF NEUROCHEMISTRY

Conformational altered p53 affects neuronal function: relevance for the response to toxic insult and growth-associated protein 43 expression

(2013) L Buizza et al.   Cell Death & Disease

Disclosure of a fundamental clue for the elucidation of the myricetin mechanism of action as amyloid aggregation inhibitor by mass spectrometry

(2012) Jessica Fiori et al.   ELECTROPHORESIS

p53 at the crossroads between cancer and neurodegeneration

(2012) Cristina Lanni et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Novel Inhibitor of Amyloid β (Aβ) Peptide Aggregation

(2012) Angela Fortner McKoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Altered p53 as an Early Marker of Oxidative Stress in Alzheimer's Disease

(2012) Laura Buizza et al.   PLoS One

Dual Effect of Beta-Amyloid on α7 and α4β2 Nicotinic Receptors Controlling the Release of Glutamate, Aspartate and GABA in Rat Hippocampus

(2012) Elisa Mura et al.   PLoS One

Kinetic characterization of amyloid-beta 1–42 aggregation with a multimethodological approach

(2011) Manuela Bartolini et al.   ANALYTICAL BIOCHEMISTRY

Zyxin Is a Critical Regulator of the Apoptotic HIPK2-p53 Signaling Axis

(2011) J. Crone et al.   CANCER RESEARCH

Nutritional Approaches to Modulate Oxidative Stress in Alzheimers Disease

(2011) C. B. Pocernich et al.   Current Alzheimer Research

The role of antioxidant versus pro-oxidant effects of green tea polyphenols in cancer prevention

(2011) Sarah C. Forester et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer’s disease treatment

(2011) A. Minarini et al.   NEUROPHARMACOLOGY

Wild type but not mutant APP is involved in protective adaptive responses against oxidants

(2010) Giovanna Cenini et al.   AMINO ACIDS

p53 Pro-Oxidant Activity in the Central Nervous System: Implication in Aging and Neurodegenerative Diseases

(2010) Wassim Chatoo et al.   ANTIOXIDANTS & REDOX SIGNALING

Control of p53 and NF-κB signaling by WIP1 and MIF: Role in cellular senescence and organismal aging

(2010) Antero Salminen et al.   CELLULAR SIGNALLING

Polyamine Conjugation of Curcumin Analogues toward the Discovery of Mitochondria-Directed Neuroprotective Agents†

(2010) Elena Simoni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Homeodomain Interacting Protein Kinase 2: A Target for Alzheimer's Beta Amyloid Leading to Misfolded p53 and Inappropriate Cell Survival

(2010) Cristina Lanni et al.   PLoS One

Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution

(2010) Harry Levine   PROTEIN SCIENCE

Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53

(2009) Stefano Salvioli et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

P53-mediated G1/S checkpoint dysfunction in lymphocytes from Alzheimer's disease patients

(2009) Xiaoying Zhou et al.   NEUROSCIENCE LETTERS

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

Synthesis of trans-caffeate analogues and their bioactivities against HIV-1 integrase and cancer cell lines

(2008) Chun-nian Xia et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of Acetylcholinesterase, β-Amyloid Aggregation, and NMDA Receptors in Alzheimer’s Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush

(2008) Michela Rosini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oxidative stress triggers the amyloidogenic pathway in human vascular smooth muscle cells

(2007) Mireia Coma et al.   NEUROBIOLOGY OF AGING