Article
Chemistry, Multidisciplinary
Peng Yang, Qianqian Huang, Jianhua Zhang, Yiwen Li, Huile Gao, Zhipeng Gu
Summary: This study presents a universal method to prepare natural polyphenolic nanodots, which demonstrate promising potential as inhibitors of amyloid aggregation in Alzheimer's disease. The nanodots not only inhibit amyloid-beta fibrillization and trigger fibril disaggregation, but also mitigate the cascade impairments caused by amyloid-beta plaques. Furthermore, the nanodots exhibit stronger antiamyloidogenic performance compared to small molecules and can cross the blood-brain barrier. The biocompatibility of the nanodots further supports their potential for clinical applications.
ADVANCED MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Arian Kola, Dorota Dudek, Daniela Valensin
Summary: Polyphenols are plant-derived compounds with potent antioxidant properties that have been studied for their benefits in preventing and treating various diseases, including cancer and neurodegenerative diseases. Their relationship with Alzheimer's disease has been extensively researched, focusing on their antioxidant properties and metal chelating features.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Chengyu Wang, Shuguo An, Zhongwei Li, Hao Chen, Zhenhu Yan, Yebang Tan
Summary: Natural polyphenols such as EGCG derived from green tea can be utilized to synthesize hyperbranched surfactants with excellent demulsification properties. These surfactants show high interfacial activity and efficient demulsification performance in aging oil emulsions from South China Sea Oilfield and Bohai Oilfield, achieving high dehydration ratios even at low concentrations and temperatures. The polyphenol structure and multiple branches of EGCG surfactants may contribute to their outstanding demulsification performance in various types of emulsions.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Multidisciplinary Sciences
N. Guthertz, R. van Der Kant, R. M. Martinez, Y. Xu, C. Trinh, B. I. Iorga, F. Rousseau, J. Schymkowitz, D. J. Brockwell, S. E. Radford
Summary: This article investigates the aggregation of a class of proteins into amyloid fibrils and reveals a mechanism underlying an amino acid substitution that causes hereditary amyloidosis. The results show that certain mutations can reduce aggregation without affecting protein stability.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Anna Sulatskaya, Anastasiia O. Kosolapova, Alexander G. Bobylev, Mikhail Belousov, Kirill S. Antonets, Maksim Sulatsky, Irina M. Kuznetsova, Konstantin K. Turoverov, Olesya Stepanenko, Anton A. Nizhnikov
Summary: Both amyloids and beta-barrel proteins have beta-sheet-rich structures, with the latter being able to form functional amyloids in vivo. These beta-barrel amyloid proteins can interact with each other and form toxic oligomers, potentially contributing to the development of amyloidoses. Rapidly growing discoveries suggest that the number and diversity of functions of amyloid-forming beta-barrel proteins are significantly greater than currently understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Ilaria Piccialli, Valentina Tedeschi, Lucia Caputo, Stefano D'Errico, Roselia Ciccone, Vincenzo De Feo, Agnese Secondo, Anna Pannaccione
Summary: Alzheimer's disease is characterized by memory loss and cognitive impairment, with multiple hypotheses proposed to explain its etiology including A beta aggregation, tau hyperphosphorylation, neuroinflammation, and oxidative stress. However, traditional single-target drug therapies have been unsuccessful in halting the brain function deterioration. A multi-target approach and lifestyle interventions targeting modifiable risk factors associated with aging are currently of great interest in Alzheimer's treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Peter K. Windsor, Stephen P. Plassmeyer, Dominic S. Mattock, Jonathan C. Bradfield, Erika Y. Choi, Bill R. Miller, Byung Hee Han
Summary: The study found that a class of biflavonoids can promote the disaggregation of Aβ fibrils, with varying potency due to structural differences. Computational analysis provided the first atomistic details for the mechanism of Aβ disaggregation by biflavonoids. Molecular docking analysis showed that biflavonoids preferably bind to the aromatic-rich, partially ordered N-termini of Aβ fibrils via pi-pi interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Filippo Basagni, Marina Naldi, Tiziana Ginex, F. Javier Luque, Francesca Fagiani, Cristina Lanni, Matteo Iurlo, Massimo Marcaccio, Anna Minarini, Manuela Bartolini, Michela Rosini
Summary: This study investigates the role of the reciprocal position of two hydroxyl functions in inhibiting the aggregation of beta-amyloid peptide. The results show that para- and ortho-derivatives effectively reduce amyloid fibrillization, while the meta-analogue has no activity. Electrochemical analyses indicate that the antiaggregating potency correlates with the oxidation potential. Mass spectrometry studies and quantum mechanical calculations reveal different modes of action for active para- and ortho-derivatives.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Alexander G. Bobylev, Roman S. Fadeev, Liya G. Bobyleva, Margarita I. Kobyakova, Yuri M. Shlyapnikov, Daniil V. Popov, Ivan M. Vikhlyantsev
Summary: The study found that amyloid aggregates of smooth-muscle titin can impair cell adhesion and lead to cell death. The surface roughness may be a key factor contributing to the highly antiadhesive properties. The negative impact of amyloid aggregates on cell adhesion is likely intrinsic to other amyloid proteins with similar structure and properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Spectroscopy
Seyyed Abolghasem Ghadami, Zahra Ahmadi, Zahra Moosavi-Nejad
Summary: By varying the temperature and pH, control of BSA-based nanoparticles/microparticles size could be achieved, thus controlling the rate of aggregation. The study provides more options for the size and shape control of BSA-based nanoparticles in natural buffer systems.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Multidisciplinary Sciences
Rodrigo Perez-Arancibia, Jose Luis Ordonez, Alexis Rivas, Philippe Pihan, Alfredo Sagredo, Ulises Ahumada, Andres Barriga, Ivette Seguel, Cesar Cardenas, Rene L. Vidal, Claudio Hetz, Carla Delporte
Summary: The study revealed that extracts from Chilean-native Ugni molinae berries contain anti-inflammatory and antioxidant components, with inhibitory effects on protein aggregation in Alzheimer's and Huntington's disease models. Particularly, extracts from the 19-1 genotype showed significant reduction in polyglutamine peptide aggregation. Additionally, the presence of flavonoids, phenolic acids, and ellagitannins in the extracts was found to be correlated with their protective effects on protein aggregation.
Article
Biochemistry & Molecular Biology
Yu Zhang, Yuying Liu, Wenhui Zhao, Yunxiang Sun
Summary: The study demonstrates that SWCNT-OH has excellent anti-amyloid properties, inhibiting the fibrillization of beta 2m(21)(-)(31) peptides and destroying pre-formed proto-fibrils.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemical Research Methods
R. Prabakaran, Puneet Rawat, Sandeep Kumar, M. Michael Gromiha
Summary: This review provides a rigorous performance analysis of nine prediction tools for protein and peptide aggregation, revealing the robustness of current prediction tools and their potential for improvement. Insights gained from this work offer critical guidance to the scientific community on the advantages and limitations of different aggregation prediction methods.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Biochemical Research Methods
Mantas Ziaunys, Kamile Mikalauskaite, Andrius Sakalauskas, Vytautas Smirnovas
Summary: The aggregation of amyloidogenic proteins is related to various diseases, with limited treatment options currently available. The challenge in the discovery of potential anti-amyloid molecules lies in identifying the actual inhibitors from complex mixtures. This study successfully scavenged potential aggregation-inhibiting molecules from different compounds and effectively separated them from the aggregates.
BIOTECHNOLOGY JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Michael C. Wilson, Qin Lu, Kaitlin R. Nachtrieb, Jackson S. Fuller, Chloe M. Skogg, Elizabeth A. Yates, Matthew D. Thum, Christopher R. So
Summary: This study demonstrates the chemical aggregation of common hydrophilic proteins into an aqueous adhesive similar to natural adhesives. By using multiple chemical denaturants, rapid gelation and further curing in artificial seawater can be achieved. The adhesive strengths of this waterborne adhesive are comparable to bioinspired adhesives that use organic solvents and hydrophobic components. This approach enables the deployment of a bioinspired adhesive at practical scales in marine environments, with sustainable production and low-cost materials.
ADVANCED FUNCTIONAL MATERIALS
(2023)