N-Heterocyclic carbene-catalyzed [3 + 3] cyclocondensation of bromoenals with hydrazones: highly enantioselective synthesis of dihydropyridazones

N-Heterocyclic carbene-catalyzed [3+3] cyclocondensation of bromoenals with aldimines: highly enantioselective synthesis of dihydropyridinones

(2015) Zhong-Hua Gao et al.   CHEMICAL COMMUNICATIONS

Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes

(2015) Darrin M. Flanigan et al.   CHEMICAL REVIEWS

N-Heterocyclic Carbene-Catalyzed Oxidative Annulations of α,β-Unsaturated Aldehydes with Hydrazones: Selective Synthesis of Optically Active 4,5-Dihydropyridazin-3-ones and Pyridazin-3-ones

(2015) Jian-Hui Mao et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of functionalized γ-lactones via a three-component cascade reaction catalyzed by consecutive N-heterocyclic carbene systems

(2015) Qian Zhao et al.   RSC Advances

On the Mechanism of N-Heterocyclic Carbene-Catalyzed Reactions Involving Acyl Azoliums

(2014) Jessada Mahatthananchai et al.   ACCOUNTS OF CHEMICAL RESEARCH

N-Heterocyclic Carbene-Catalyzed Enantioselective Annulation of Indolin-3-ones with Bromoenals

(2014) Qijian Ni et al.   Chemistry-An Asian Journal

Synthesis of Functionalized Coumarins and Quinolinones by NHC-Catalyzed Annulation of Modified Enals with Heterocyclic C–H Acids

(2014) Santhivardhana Reddy Yetra et al.   JOURNAL OF ORGANIC CHEMISTRY

An overview of N-heterocyclic carbenes

(2014) Matthew N. Hopkinson et al.   NATURE

Highly Stereoselective Synthesis of Functionalized Pyrrolo[3,2-c]quinolines via N-Heterocyclic Carbene Catalyzed Cascade Sequence

(2014) Yu-Jie Yang et al.   ORGANIC LETTERS

Bifunctional N-Heterocyclic Carbene-Catalyzed Highly Enantioselective Synthesis of Spirocyclic Oxindolo-β-lactams

(2014) Han-Ming Zhang et al.   ORGANIC LETTERS

N-Heterocyclic Carbene-Catalyzed [3+3] Cyclocondensation of Bromoenals and Ketimines: Highly Enantioselective Synthesis of Dihydropyridinones

(2014) Han-Ming Zhang et al.   Asian Journal of Organic Chemistry

Enantioselective N-Heterocyclic Carbene-Catalyzed Annulations of 2-Bromoenals with 1,3-Dicarbonyl Compounds and EnaminesviaChiral α,β-Unsaturated Acylazoliums

(2013) Santhivardhana Reddy Yetra et al.   ADVANCED SYNTHESIS & CATALYSIS

Highly Enantioselective γ-Amination by N-Heterocyclic Carbene Catalyzed [4+2] Annulation of Oxidized Enals and Azodicarboxylates

(2013) Xiang-Yu Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Ion Pair Catalysis of 6π Electrocyclizations: Brønsted Acid Catalyzed Enantioselective Synthesis of Optically Active 1,4-Dihydropyridazines

(2013) Arindam Das et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acyl anion free N-heterocyclic carbene organocatalysis

(2013) Sarah J. Ryan et al.   CHEMICAL SOCIETY REVIEWS

β-Carbon activation of saturated carboxylic esters through N-heterocyclic carbene organocatalysis

(2013) Zhenqian Fu et al.   Nature Chemistry

An internal affair

(2013) Jeffrey W. Bode   Nature Chemistry

Asymmetric N-Heterocyclic Carbene (NHC)-Catalyzed Annulation of Modified Enals with Enolizable Aldehydes

(2013) Santhivardhana Reddy Yetra et al.   ORGANIC LETTERS

N-Heterocyclic Carbene-Catalyzed Stereoselective Cascade Reaction: Synthesis of Functionalized Tetrahydroquinolines

(2013) Hai-Rui Zhang et al.   ORGANIC LETTERS

Catalytic Asymmetric Construction of Chiral Hydropyridazines via Conjugate Addition of N-Monosubstituted Hydrazones to Enones

(2013) Wenbin Wu et al.   ORGANIC LETTERS

Organocatalytic Enantioselective γ-Aminoalkylation of Unsaturated Ester: Access to Pipecolic Acid Derivatives

(2013) Jianfeng Xu et al.   ORGANIC LETTERS

Enantioselective Cycloaddition Reactions of Ketenes Catalyzed by N-Heterocyclic Carbenes

(2013) Song Ye et al.   SYNLETT

Exploiting Acyl and Enol Azolium Intermediates via N-Hetero- cyclic Carbene-Catalyzed Reactions of α-Reducible Aldehydes

(2012) Harit U. Vora et al.   ADVANCED SYNTHESIS & CATALYSIS

A Continuum of Progress: Applications of N-Hetereocyclic Carbene Catalysis in Total Synthesis

(2012) Javier Izquierdo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual β2-adrenoceptor agonists-PDE4 inhibitors for the treatment of asthma and COPD

(2012) Wen-Jun Shan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phosphodiesterase inhibitors. Part 5: Hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration

(2012) Koji Ochiai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

NHC-catalyzed C–O or C–N bond formation: efficient approaches to α,β-unsaturated esters and amides

(2012) Bo Zhang et al.   CHEMICAL COMMUNICATIONS

Organocatalytic umpolung: N-heterocyclic carbenes and beyond

(2012) Xavier Bugaut et al.   CHEMICAL SOCIETY REVIEWS

N-Heterocyclic Carbene Catalyzed Reactions of α-Bromo-α,β-unsaturated Aldehydes/α,β-Dibromoaldehydes with 1,3-Dinucleophilic Reagents

(2012) Changsheng Yao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Conjugate Addition of Donor–Acceptor Hydrazones to α,β-Unsaturated Aldehydes through Formal Diaza–Ene Reaction: Access to 1,4-Dicarbonyl Compounds

(2012) Maitane Fernández et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Formal Carbonyl-Ene Reactions of Formaldehyde tert-Butyl Hydrazone with α-Keto Esters: Dual Activation by Bis-urea Catalysts

(2012) Ana Crespo-Peña et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A review of the pharmacology and clinical uses of pimobendan.

(2012) Kimberly L. Boyle et al.   JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE

Pyridazin-3(2H)-ones: the versatile pharmacophore of medicinal significance

(2012) Ranju Bansal et al.   MEDICINAL CHEMISTRY RESEARCH

NHC-catalyzed cascade synthesis of 1-substituted 4-aryl-tetrahydroquinoline-2,5-diones

(2012) Changsheng Yao et al.   TETRAHEDRON

N-Heterocyclic Carbene-Catalyzed Enantioselective Annulation of Bromoenal and 1,3-Dicarbonyl Compounds

(2011) Fang-Gang Sun et al.   ADVANCED SYNTHESIS & CATALYSIS

N-Heterocyclic Carbene Catalyzed Domino Reactions

(2011) André Grossmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective γ-Amination of α,β-Unsaturated Acyl Chlorides with Azodicarboxylates: Efficient Synthesis of Chiral γ-Amino Acid Derivatives

(2011) Li-Tao Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Triazole incorporated pyridazinones as a new class of antihypertensive agents: Design, synthesis and in vivo screening

(2010) Anees A. Siddiqui et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, characterization and antihypertensive activity of pyridazinone derivatives

(2010) Anees A. Siddiqui et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cooperative catalysis by carbenes and Lewis acids in a highly stereoselective route to γ-lactams

(2010) Dustin E. A. Raup et al.   Nature Chemistry

N-Heterocyclic Carbene Catalyzed Transformations of 3-Halopropenals to the Equivalents of β-Acylvinyl Anions

(2010) Yihua Wu et al.   ORGANIC LETTERS

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Chiral N-Heterocyclic Carbene Catalyzed Staudinger Reaction of Ketenes with Imines:  Highly Enantioselective Synthesis ofN-Boc β-Lactams

(2007) Yan-Rong Zhang et al.   ORGANIC LETTERS