期刊
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
卷 50, 期 6, 页码 1005-1009出版社
AMER THORACIC SOC
DOI: 10.1165/rcmb.2014-0019TR
关键词
integrated stress response; lung; endoplasmic reticulum stress
资金
- Medical Research Council [G0601840, G1002610] Funding Source: Medline
- Wellcome Trust [100140] Funding Source: Medline
- MRC [G1002610, G0601840] Funding Source: UKRI
- Medical Research Council [G0601840, G1002610] Funding Source: researchfish
Lungs are repeatedly exposed to inhaled toxic insults, such as smoke, diesel exhaust, and microbes, which elicit cellular stress responses. The phosphorylation of eukaryotic translation initiation factor 2 alpha by one of four stress-sensing kinases triggers a pathway called the integrated stress response that helps protect cellular reserves of nutrients and prevents the accumulation of toxic proteins. In this review, we discuss how activation of the integrated stress response has been shown to play an important role in pulmonary pathology, and how its study may help in the development of novel therapies for diverse conditions, from hypoxia to cancer.
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