Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic

Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress

(2014) Ruben K. Dagda et al.   Autophagy

Mitochondrial Metabolism Modulation: A New Therapeutic Approach for Parkinsons Disease

(2012) D. Arduino et al.   CNS & Neurological Disorders-Drug Targets

Does Mitochondrial DNA Play a Role in Parkinson's Disease? A Review of Cybrid and Other Supportive Evidence

(2011) Russell H. Swerdlow   ANTIOXIDANTS & REDOX SIGNALING

Toxin Models of Mitochondrial Dysfunction in Parkinson's Disease

(2011) Terina N. Martinez et al.   ANTIOXIDANTS & REDOX SIGNALING

ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells

(2011) Daniela M. Arduino et al.   BMB Reports

Introduction

(2011) Charleen T. Chu   BRAIN PATHOLOGY

Therapeutic Intervention at Cellular Quality Control Systems in Alzheimers and Parkinsons Diseases

(2011) Daniela M. Arduino et al.   CURRENT PHARMACEUTICAL DESIGN

The Mitochondrial Cascade Hypothesis for Parkinsons Disease

(2011) Sandra M. Cardoso   CURRENT PHARMACEUTICAL DESIGN

Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy

(2011) S. Lee et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

(2010) Joo-Yong Lee et al.   EMBO JOURNAL

Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization

(2010) Victor S. Van Laar et al.   HUMAN MOLECULAR GENETICS

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

(2010) Joo-Yong Lee et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial respiration and respiration-associated proteins in cell lines created through Parkinson’s subject mitochondrial transfer

(2010) A. Raquel Esteves et al.   JOURNAL OF NEUROCHEMISTRY

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond

(2010) Sarah F. Funderburk et al.   TRENDS IN CELL BIOLOGY

Microtubule depolymerization potentiates alpha-synuclein oligomerization

(2010) A. Raquel Esteves   Frontiers in Aging Neuroscience

In search of an “autophagomometer”

(2009) David C. Rubinsztein et al.   Autophagy

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced axonal transport in Parkinson's disease cybrid neurites is restored by light therapy

(2009) Patricia A Trimmer et al.   Molecular Neurodegeneration

Dysfunctional mitochondria uphold calpain activation: Contribution to Parkinson's disease pathology

(2009) A. Raquel Esteves et al.   NEUROBIOLOGY OF DISEASE

Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: Relevance to Parkinson's disease

(2009) Daniela Moniz Arduíno et al.   NEUROCHEMISTRY INTERNATIONAL

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

(2009) Andrew F. MacAskill et al.   NEURON

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

(2009) Maria Xilouri et al.   PLoS One

Oxidative Stress Involvement in α-Synuclein Oligomerization in Parkinson's Disease Cybrids

(2008) A. Raquel Esteves et al.   ANTIOXIDANTS & REDOX SIGNALING

Dynein-dependent Movement of Autophagosomes Mediates Efficient Encounters with Lysosomes

(2008) Shunsuke Kimura et al.   CELL STRUCTURE AND FUNCTION

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial function in Parkinson’s disease cybrids containing an nt2 neuron-like nuclear background

(2008) A. Raquel F. Esteves et al.   MITOCHONDRION

The Itinerary of Autophagosomes: From Peripheral Formation to Kiss-and-Run Fusion with Lysosomes

(2008) Luca Jahreiss et al.   TRAFFIC