Safe prescribing of non-steroidal anti-inflammatory drugs in patients with osteoarthritis – an expert consensus addressing benefits as well as gastrointestinal and cardiovascular risks

GI-REASONS: A Novel 6-Month, Prospective, Randomized, Open-Label, Blinded Endpoint (PROBE) Trial

(2013) Byron Cryer et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

NSAIDs Inhibit Tumorigenesis, but How?

(2013) Evrim Gurpinar et al.   CLINICAL CANCER RESEARCH

Risk factors for severe nonsteroidal anti-inflammatory drug-induced small intestinal damage

(2013) Toshio Watanabe et al.   DIGESTIVE AND LIVER DISEASE

Time trends and outcome of gastrointestinal bleeding in the Veneto Region: A retrospective population based study from 2001 to 2010

(2013) Lucas G. Cavallaro et al.   DIGESTIVE AND LIVER DISEASE

Low-dose aspirin in primary prevention: cardioprotection, chemoprevention, both, or neither?

(2013) C. Patrono   EUROPEAN HEART JOURNAL

Comorbidities Affect Risk of Nonvariceal Upper Gastrointestinal Bleeding

(2013) Colin John Crooks et al.   GASTROENTEROLOGY

Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials

(2013)   LANCET

Patient-level pooled analysis of adjudicated gastrointestinal outcomes in celecoxib clinical trials: meta-analysis of 51,000 patients enrolled in 52 randomized trials

(2013) Andrew Moore et al.   ARTHRITIS RESEARCH & THERAPY

Risk factors associated with a decrease ≥2 g/dL in haemoglobin and/or ≥10% haematocrit in osteoarthritis patients taking celecoxib or a nonselective NSAID plus a PPI in a large randomised controlled trial (CONDOR)

(2012) A. Lanas et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Prescription of and Adherence to Non-Steroidal Anti-Inflammatory Drugs and Gastroprotective Agents in At-Risk Gastrointestinal Patients

(2012) Angel Lanas et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Trends for Incidence of Hospitalization and Death Due to GI Complications in the United States From 2001 to 2009

(2012) Loren Laine et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Adherence to gastroprotection during cyclooxygenase 2 inhibitor treatment and the risk of upper gastrointestinal tract events: A population-based study

(2012) Vera E. Valkhoff et al.   ARTHRITIS AND RHEUMATISM

European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts) * Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)

(2012) et al.   EUROPEAN HEART JOURNAL

Interference of NSAIDs with the thrombocyte inhibitory effect of aspirin: A placebo-controlled, ex vivo, serial placebo-controlled serial crossover study

(2012) I. L. Meek et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Management ofHelicobacter pyloriinfection—the Maastricht IV/ Florence Consensus Report

(2012) Peter Malfertheiner et al.   GUT

Comparison of gastrointestinal adverse effects between cyclooxygenase-2 inhibitors and non-selective, non-steroidal anti-inflammatory drugs plus proton pump inhibitors: a systematic review and meta-analysis

(2012) Saharat Jarupongprapa et al.   JOURNAL OF GASTROENTEROLOGY

Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials

(2012) Annemijn M Algra et al.   LANCET ONCOLOGY

Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)

(2012) F. Berenbaum   OSTEOARTHRITIS AND CARTILAGE

Concordance with Guideline Recommendations: previous and more recent Nonsteroidal anti-inflammatory Drug prescriptions in Quebec, Canada

(2012) Elham Rahme et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee

(2012) Marc C. Hochberg et al.   ARTHRITIS CARE & RESEARCH

The cost-effectiveness of celecoxib vs diclofenac in the treatment of osteoarthritis in the UK; an update to the NICE model using data from the CONDOR trial

(2012) N. Brereton et al.   JOURNAL OF MEDICAL ECONOMICS

Increased mortality in ankylosing spondylitis is related to disease activity

(2011) G. Bakland et al.   ANNALS OF THE RHEUMATIC DISEASES

Prescription patterns and appropriateness of NSAID therapy according to gastrointestinal risk and cardiovascular history in patients with diagnoses of osteoarthritis

(2011) Angel Lanas et al.   BMC Medicine

The Use of Antiplatelet Therapy in the Outpatient Setting: Canadian Cardiovascular Society Guidelines

(2011) Alan D. Bell et al.   CANADIAN JOURNAL OF CARDIOLOGY

Duration of Treatment With Nonsteroidal Anti-Inflammatory Drugs and Impact on Risk of Death and Recurrent Myocardial Infarction in Patients With Prior Myocardial Infarction

(2011) Anne-Marie Schjerning Olsen et al.   CIRCULATION

Risk of Upper Gastrointestinal Bleeding With Low-Dose Acetylsalicylic Acid Alone and in Combination With Clopidogrel and Other Medications

(2011) Luis A. García Rodríguez et al.   CIRCULATION

Low Doses of Acetylsalicylic Acid Increase Risk of Gastrointestinal Bleeding in a Meta-Analysis

(2011) Angel Lanas et al.   Clinical Gastroenterology and Hepatology

Fixed-dose combination of enteric-coated naproxen and immediate-release esomeprazole has comparable efficacy to celecoxib for knee osteoarthritis: two randomized trials

(2011) Marc C. Hochberg et al.   CURRENT MEDICAL RESEARCH AND OPINION

Aging and osteoarthritis

(2011) Richard F. Loeser   CURRENT OPINION IN RHEUMATOLOGY

Proton Pump Inhibitors Exacerbate NSAID-Induced Small Intestinal Injury by Inducing Dysbiosis

(2011) John L. Wallace et al.   GASTROENTEROLOGY

Non-steroidal anti-inflammatory drugs and risk of lower gastrointestinal adverse events: a nationwide study in Taiwan

(2011) C.-H. Chang et al.   GUT

Suboptimal gastroprotective coverage of NSAID use and the risk of upper gastrointestinal bleeding and ulcers: an observational study using three European databases

(2011) E. M. van Soest et al.   GUT

Age As a Risk Factor

(2011) Ravi Dhingra et al.   MEDICAL CLINICS OF NORTH AMERICA

NSAIDs vs acetaminophen in knee and hip osteoarthritis: a systematic review regarding heterogeneity influencing the outcomes

(2011) S.P.J. Verkleij et al.   OSTEOARTHRITIS AND CARTILAGE

Incidence of gastrointestinal bleeding in patients with cardiovascular disease: buffered aspirin versus enteric-coated aspirin

(2011) Yoshikazu Hirata et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Cardiovascular Risk with Non-Steroidal Anti-Inflammatory Drugs: Systematic Review of Population-Based Controlled Observational Studies

(2011) Patricia McGettigan et al.   PLOS MEDICINE

Time-trends in gastroprotection with nonsteroidal anti-inflammatory drugs (NSAIDs)

(2010) V. E. VALKHOFF et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The appropriate use of non-steroidal anti-inflammatory drugs in rheumatic disease: opinions of a multidisciplinary European expert panel

(2010) G. Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

Assessment of gastrointestinal and cardiovascular risk in patients with osteoarthritis who require NSAIDs: the LOGICA study

(2010) A. Lanas et al.   ANNALS OF THE RHEUMATIC DISEASES

Low-dose naproxen interferes with the antiplatelet effects of aspirin in healthy subjects: Recommendations to minimize the functional consequences

(2010) Paola Anzellotti et al.   ARTHRITIS AND RHEUMATISM

Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment

(2010) Andrew J. McLachlan et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Acetaminophen Increases Blood Pressure in Patients With Coronary Artery Disease

(2010) Isabella Sudano et al.   CIRCULATION

Increased Incidence of Small Intestinal Bacterial Overgrowth During Proton Pump Inhibitor Therapy

(2010) Lucio Lombardo et al.   Clinical Gastroenterology and Hepatology

Age-Related Changes in the Musculoskeletal System and the Development of Osteoarthritis

(2010) Richard F. Loeser   CLINICS IN GERIATRIC MEDICINE

QUANTITATIVE ANALYSIS OF LOW-DOSE ASPIRIN-ASSOCIATED SMALL BOWEL INJURY USING A CAPSULE ENDOSCOPY SCORING INDEX

(2010) Hiroki Endo et al.   Digestive Endoscopy

Distribution of small intestinal mucosal injuries as a result of NSAID administration

(2010) Shunji Fujimori et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Effects of long-term PPI treatment on producing bowel symptoms and SIBO

(2010) Debora Compare et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Nonsteroidal Antiinflammatory Drug-Related Injury to the Gastrointestinal Tract: Clinical Picture, Pathogenesis, and Prevention

(2010) Carmelo Scarpignato et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Do musculoskeletal degenerative diseases affect mortality and cause of death after 10 years in Japan?

(2010) Masaki Tsuboi et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial

(2010) Francis KL Chan et al.   LANCET

Correlation of pain relief with physical function in hand osteoarthritis: randomized controlled trial post hoc analysis

(2010) H Richard Barthel et al.   ARTHRITIS RESEARCH & THERAPY

Celecoxib Does Not Attenuate the Antiplatelet Effects of Aspirin and Clopidogrel in Healthy Volunteers

(2010) Wonjae Lee et al.   Korean Circulation Journal

FDA proposals to limit the hepatotoxicity of paracetamol (acetaminophen): are they reasonable?

(2010) Garry G. Graham et al.   INFLAMMOPHARMACOLOGY

Rationale, design, and governance of Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen Or Naproxen (PRECISION), a cardiovascular end point trial of nonsteroidal antiinflammatory agents in patients with arthritis

(2009) Matthew C. Becker et al.   AMERICAN HEART JOURNAL

Causes of Mortality in Patients With Peptic Ulcer Bleeding: A Prospective Cohort Study of 10,428 Cases

(2009) Joseph J Y Sung et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Time Trends and Impact of Upper and Lower Gastrointestinal Bleeding and Perforation in Clinical Practice

(2009) Angel Lanas et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Guidelines for Prevention of NSAID-Related Ulcer Complications

(2009) Frank L Lanza et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Myths and facts in the use of anti-inflammatory drugs

(2009) Richard H. Hunt et al.   ANNALS OF MEDICINE

The interaction of ibuprofen and diclofenac with aspirin in healthy volunteers

(2009) MP Schuijt et al.   BRITISH JOURNAL OF PHARMACOLOGY

Gastroprotection among new chronic users of non-steroidal anti-inflammatory drugs: a study of utilization and adherence in the Netherlands

(2009) Michiel W. Van der Linden et al.   CURRENT MEDICAL RESEARCH AND OPINION

Severe chronic pain is associated with increased 10 year mortality. A cohort record linkage study

(2009) Nicola Torrance et al.   EUROPEAN JOURNAL OF PAIN

Nonsteroidal Anti-Inflammatory Drugs and Lower Gastrointestinal Complications

(2009) Angel Lanas et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Characteristics of small bowel injury in symptomatic chronic low-dose aspirin users: the experience of two medical centers in capsule endoscopy

(2009) Hiroki Endo et al.   JOURNAL OF GASTROENTEROLOGY

A Novel Composite Endpoint to Evaluate the Gastrointestinal (GI) Effects of Nonsteroidal Antiinflammatory Drugs Through the Entire GI Tract

(2009) F. K. L. CHAN et al.   JOURNAL OF RHEUMATOLOGY

Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials

(2009)   LANCET

Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement

(2009) Jack Cuzick et al.   LANCET ONCOLOGY

Canadian consensus guidelines on long-term nonsteroidal anti-inflammatory drug therapy and the need for gastroprotection: benefits versus risks

(2008) A. ROSTOM et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The Antiplatelet Effect of Six Non-Steroidal Anti-Inflammatory Drugs and Their Pharmacodynamic Interaction With Aspirin in Healthy Volunteers

(2008) Patrick A. Gladding et al.   AMERICAN JOURNAL OF CARDIOLOGY

ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use

(2008) Deepak L. Bhatt et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Management of Patients on Nonsteroidal Anti-inflammatory Drugs: A Clinical Practice Recommendation From the First International Working Party on Gastrointestinal and Cardiovascular Effects of Nonsteroidal Anti-inflammatory Drugs and Anti-platelet Agents

(2008) Francis K.L. Chan et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Recommendations for use of selective and nonselective nonsteroidal antiinflammatory drugs: An American College of Rheumatology white paper

(2008)   ARTHRITIS AND RHEUMATISM

Cardiovascular Risk of Celecoxib in 6 Randomized Placebo-Controlled Trials

(2008) Scott D. Solomon et al.   CIRCULATION

Low-Dose Aspirin Affects the Small Bowel Mucosa: Results of a Pilot Study With a Multidimensional Assessment

(2008) Edgardo Smecuol et al.   Clinical Gastroenterology and Hepatology

Functionality and health-status benefits associated with reduction of osteoarthritis pain

(2008) Jeff R. Schein et al.   CURRENT MEDICAL RESEARCH AND OPINION

Lower Gastrointestinal Events in a Double-Blind Trial of the Cyclo-Oxygenase-2 Selective Inhibitor Etoricoxib and the Traditional Nonsteroidal Anti-Inflammatory Drug Diclofenac

(2008) Loren Laine et al.   GASTROENTEROLOGY

NSAID-induced intestinal damage: are luminal bacteria the therapeutic target?

(2008) C Scarpignato   GUT

OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

(2008) W. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Use of NSAIDs and infection with Helicobacter pylori--what does the rheumatologist need to know?

(2008) U. Kiltz et al.   RHEUMATOLOGY

Faecal blood loss with aspirin, nonsteroidal anti-inflammatory drugs and cyclo-oxygenase-2 selective inhibitors: systematic review of randomized trials using autologous chromium-labelled erythrocytes

(2008) R Andrew Moore et al.   ARTHRITIS RESEARCH & THERAPY

Assessment of the Risk Factors for Colonic Diverticular Hemorrhage

(2007) Atsuo Yamada et al.   DISEASES OF THE COLON & RECTUM

Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man

(2007) Burkhard Hinz et al.   FASEB JOURNAL

Effects of Ibuprofen on the Magnitude and Duration of Aspirin's Inhibition of Platelet Aggregation: Clinical Consequences in Stroke Prophylaxis

(2007) Franci M. Gengo et al.   JOURNAL OF CLINICAL PHARMACOLOGY