Cheating evolution: engineering gene drives to manipulate the fate of wild populations

The dawn of active genetics

(2015) Valentino M. Gantz et al.   BIOESSAYS

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

(2015) Bernd Zetsche et al.   CELL

Modeling the Manipulation of Natural Populations by the Mutagenic Chain Reaction

(2015) Robert L. Unckless et al.   GENETICS

Safeguarding CRISPR-Cas9 gene drives in yeast

(2015) James E DiCarlo et al.   NATURE BIOTECHNOLOGY

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

(2015) Van Trung Chu et al.   NATURE BIOTECHNOLOGY

A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae

(2015) Andrew Hammond et al.   NATURE BIOTECHNOLOGY

Small molecule–triggered Cas9 protein with improved genome-editing specificity

(2015) Kevin M Davis et al.   Nature Chemical Biology

Cas9-mediated targeting of viral RNA in eukaryotic cells

(2015) Aryn A. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opinion: Is CRISPR-based gene drive a biocontrol silver bullet or global conservation threat?: Fig. 1.

(2015) Bruce L. Webber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Silencing of end-joining repair for efficient site-specific gene insertion after TALEN/CRISPR mutagenesis inAedes aegypti

(2015) Sanjay Basu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Boosting CRISPR/Cas9 multiplex editing capability with the endogenous tRNA-processing system

(2015) Kabin Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquitoAnopheles stephensi

(2015) Valentino M. Gantz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations

(2015) V. M. Gantz et al.   SCIENCE

Safeguarding gene drive experiments in the laboratory

(2015) O. S. Akbari et al.   SCIENCE

Rationally engineered Cas9 nucleases with improved specificity

(2015) I. M. Slaymaker et al.   SCIENCE

Genome Engineering with CRISPR-Cas9 in the Mosquito Aedes aegypti

(2015) Kathryn E. Kistler et al.   Cell Reports

Suppression of a Field Population of Aedes aegypti in Brazil by Sustained Release of Transgenic Male Mosquitoes

(2015) Danilo O. Carvalho et al.   PLoS Neglected Tropical Diseases

Modeling the Manipulation of Natural Populations by the Mutagenic Chain Reaction

(2015) Robert L. Unckless et al.   GENETICS

Disruption of dengue virus transmission by mosquitoes

(2015) Alexander WE Franz et al.   Current Opinion in Insect Science

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

(2014) S. Bae et al.   BIOINFORMATICS

Dynamics of a combined medea-underdominant population transformation system

(2014) Chaitanya S Gokhale et al.   BMC EVOLUTIONARY BIOLOGY

Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos

(2014) Yuyu Niu et al.   CELL

Interplay of population genetics and dynamics in the genetic control of mosquitoes

(2014) N. Alphey et al.   Journal of the Royal Society Interface

Programmable RNA recognition and cleavage by CRISPR/Cas9

(2014) Mitchell R. O’Connell et al.   NATURE

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

(2014) Shengdar Q Tsai et al.   NATURE BIOTECHNOLOGY

Microhomology-based choice of Cas9 nuclease target sites

(2014) Sangsu Bae et al.   NATURE METHODS

Development of synthetic selfish elements based on modular nucleases in Drosophila melanogaster

(2014) Alekos Simoni et al.   NUCLEIC ACIDS RESEARCH

Heritable strategies for controlling insect vectors of disease

(2014) A. Burt   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

sgRNAcas9: A Software Package for Designing CRISPR sgRNA and Evaluating Potential Off-Target Cleavage Sites

(2014) Shengsong Xie et al.   PLoS One

First Steps towards Underdominant Genetic Transformation of Insect Populations

(2014) R. Guy Reeves et al.   PLoS One

Medusa: A Novel Gene Drive System for Confined Suppression of Insect Populations

(2014) John M. Marshall et al.   PLoS One

Site-specific genetic engineering of the Anopheles gambiae Y chromosome

(2014) F. Bernardini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene drives raise dual-use concerns

(2014) D. Gurwitz   SCIENCE

Gene drives raise dual-use concerns--Response

(2014) K. A. Oye et al.   SCIENCE

Regulating gene drives

(2014) K. A. Oye et al.   SCIENCE

Sex Chromosome Drive

(2014) Quentin Helleu et al.   Cold Spring Harbor Perspectives in Biology

A synthetic sex ratio distortion system for the control of the human malaria mosquito

(2014) Roberto Galizi et al.   Nature Communications

Identification of germline transcriptional regulatory elements in Aedes aegypti

(2014) Omar S. Akbari et al.   Scientific Reports

Maternal Germline-Specific Genes in the Asian Malaria Mosquito Anopheles stephensi : Characterization and Application for Disease Control

(2014) James K. Biedler et al.   G3-Genes Genomes Genetics

Fitness Impact and Stability of a Transgene Conferring Resistance to Dengue-2 Virus following Introgression into a Genetically Diverse Aedes aegypti Strain

(2014) Alexander W. E. Franz et al.   PLoS Neglected Tropical Diseases

Concerning RNA-guided gene drives for the alteration of wild populations

(2014) Kevin M Esvelt et al.   eLife

Is homologous recombination really an error-free process?

(2014) Josée Guirouilh-Barbat et al.   Frontiers in Genetics

Biology and Management of Asian Citrus Psyllid, Vector of the Huanglongbing Pathogens

(2013) Elizabeth E. Grafton-Cardwell et al.   Annual Review of Entomology

Genetic Control of Mosquitoes

(2013) Luke Alphey   Annual Review of Entomology

Generation of gene-modified mice via Cas9/RNA-mediated gene targeting

(2013) Bin Shen et al.   CELL RESEARCH

Evolution and biology of supernumerary B chromosomes

(2013) Andreas Houben et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Synthetic Gene Drive System for Local, Reversible Modification and Suppression of Insect Populations

(2013) Omar S. Akbari et al.   CURRENT BIOLOGY

Wolbachia and arbovirus inhibition in mosquitoes

(2013) Steven P Sinkins   Future Microbiology

Exciting Prospects for Precise Engineering of Caenorhabditis elegans Genomes with CRISPR/Cas9

(2013) Christian Frøkjær-Jensen   GENETICS

Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease

(2013) Scott J. Gratz et al.   GENETICS

Self-processing of ribozyme-flanked RNAs into guide RNAsin vitroandin vivofor CRISPR-mediated genome editing

(2013) Yangbin Gao et al.   Journal of Integrative Plant Biology

Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9

(2013) Jian-Feng Li et al.   NATURE BIOTECHNOLOGY

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

Cas9 as a versatile tool for engineering biology

(2013) Prashant Mali et al.   NATURE METHODS

Optimising Homing Endonuclease Gene Drive Performance in a Semi-Refractory Species: The Drosophila melanogaster Experience

(2013) Yuk-Sang Chan et al.   PLoS One

The Design and In Vivo Evaluation of Engineered I-OnuI-Based Enzymes for HEG Gene Drive

(2013) Yuk-Sang Chan et al.   PLoS One

Modeling the Dynamics of a Non-Limited and a Self-Limited Gene Drive System in Structured Aedes aegypti Populations

(2013) Mathieu Legros et al.   PLoS One

Complex history of the amphibian-killing chytrid fungus revealed with genome resequencing data

(2013) Erica Bree Rosenblum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wolbachia Invades Anopheles stephensi Populations and Induces Refractoriness to Plasmodium Infection

(2013) G. Bian et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Genetic approaches to interfere with malaria transmission by vector mosquitoes

(2013) Sibao Wang et al.   TRENDS IN BIOTECHNOLOGY

Release of genetically engineered insects: a framework to identify potential ecological effects

(2013) Aaron S. David et al.   Ecology and Evolution

Transcriptome Profiling of Nasonia vitripennis Testis Reveals Novel Transcripts Expressed from the Selfish B Chromosome, Paternal Sex Ratio

(2013) Omar S. Akbari et al.   G3-Genes Genomes Genetics

Genetic control ofAedesmosquitoes

(2013) Luke Alphey et al.   Pathogens and Global Health

Replacing a Native Wolbachia with a Novel Strain Results in an Increase in Endosymbiont Load and Resistance to Dengue Virus in a Mosquito Vector

(2013) Guowu Bian et al.   PLoS Neglected Tropical Diseases

GENERAL PRINCIPLES OF SINGLE-CONSTRUCT CHROMOSOMAL GENE DRIVE

(2012) John M. Marshall et al.   EVOLUTION

Reduction of malaria transmission by transgenic mosquitoes expressing an antisporozoite antibody in their salivary glands

(2012) M. Sumitani et al.   INSECT MOLECULAR BIOLOGY

Successful suppression of a field mosquito population by sustained release of engineered male mosquitoes

(2012) Angela F Harris et al.   NATURE BIOTECHNOLOGY

Open Field Release of Genetically Engineered Sterile Male Aedes aegypti in Malaysia

(2012) Renaud Lacroix et al.   PLoS One

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Novel Synthetic Medea Selfish Genetic Elements Drive Population Replacement in Drosophila; a Theoretical Exploration of Medea-Dependent Population Suppression

(2012) Omar S. Akbari et al.   ACS Synthetic Biology

Infertility resulting from transgenic I-PpoI maleAnopheles gambiaein large cage trials

(2012) T A Klein et al.   Pathogens and Global Health

Considerations in the Design of Clinical Trials to Test Novel Entomological Approaches to Dengue Control

(2012) Marcel Wolbers et al.   PLoS Neglected Tropical Diseases

The Importance of Long-Term Social Research in Enabling Participation and Developing Engagement Strategies for New Dengue Control Technologies

(2012) Darlene McNaughton   PLoS Neglected Tropical Diseases

Insect Population Control by Homing Endonuclease-Based Gene Drive: An Evaluation inDrosophila melanogaster

(2011) Yuk-Sang Chan et al.   GENETICS

Inverse Medea as a Novel Gene Drive System for Local Population Replacement: A Theoretical Analysis

(2011) J. M. Marshall et al.   JOURNAL OF HEREDITY

Confinement of gene drive systems to local populations: A comparative analysis

(2011) John M. Marshall et al.   JOURNAL OF THEORETICAL BIOLOGY

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

(2011) Nikolai Windbichler et al.   NATURE

The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations

(2011) T. Walker et al.   NATURE

Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission

(2011) A. A. Hoffmann et al.   NATURE

Field performance of engineered male mosquitoes

(2011) Angela F Harris et al.   NATURE BIOTECHNOLOGY

Field Performance of a Genetically Engineered Strain of Pink Bollworm

(2011) Gregory S. Simmons et al.   PLoS One

Requirements for effective malaria control with homing endonuclease genes

(2011) A. Deredec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selfish genetic elements, genetic conflict, and evolutionary innovation

(2011) J. H. Werren   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wolbachia strain wMel induces cytoplasmic incompatibility and blocks dengue transmission in Aedes albopictus

(2011) M. S. C. Blagrove et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homing Endonucleases: From Microbial Genetic Invaders to Reagents for Targeted DNA Modification

(2011) Barry L. Stoddard   STRUCTURE

Stability Properties of Underdominance in Finite Subdivided Populations

(2011) Philipp M. Altrock et al.   PLoS Computational Biology

MEDEA SELFISH GENETIC ELEMENTS AS TOOLS FOR ALTERING TRAITS OF WILD POPULATIONS: A THEORETICAL ANALYSIS

(2010) Catherine M. Ward et al.   EVOLUTION

Gene-drive into insect populations with age and spatial structure: a theoretical assessment

(2010) Yunxin Huang et al.   Evolutionary Applications

Mobility properties of the Hermes transposable element in transgenic lines of Aedes aegypti

(2010) Ryan C. Smith et al.   GENETICA

Semele: A Killer-Male, Rescue-Female System for Suppression and Replacement of Insect Disease Vector Populations

(2010) J. M. Marshall et al.   GENETICS

Engineering the genomes of wild insect populations: Challenges, and opportunities provided by synthetic Medea selfish genetic elements

(2010) Bruce A. Hay et al.   JOURNAL OF INSECT PHYSIOLOGY

Using underdominance to bi-stably transform local populations

(2010) Philipp M. Altrock et al.   JOURNAL OF THEORETICAL BIOLOGY

Perspectives of people in Mali toward genetically-modified mosquitoes for malaria control

(2010) John M Marshall et al.   MALARIA JOURNAL

The Cartagena Protocol and genetically modified mosquitoes

(2010) John M Marshall   NATURE BIOTECHNOLOGY

Activation of Akt Signaling Reduces the Prevalence and Intensity of Malaria Parasite Infection and Lifespan in Anopheles stephensi Mosquitoes

(2010) Vanessa Corby-Harris et al.   PLoS Pathogens

A Wolbachia Symbiont in Aedes aegypti Limits Infection with Dengue, Chikungunya, and Plasmodium

(2009) Luciano A. Moreira et al.   CELL

The effect of gene drive on containment of transgenic mosquitoes

(2009) John M. Marshall   JOURNAL OF THEORETICAL BIOLOGY

Immune Activation by Life-Shortening Wolbachia and Reduced Filarial Competence in Mosquitoes

(2009) Z. Kambris et al.   SCIENCE

Stable Introduction of a Life-Shortening Wolbachia Infection into the Mosquito Aedes aegypti

(2009) C. J. McMeniman et al.   SCIENCE

The Genetics and Cell Biology ofWolbachia-Host Interactions

(2008) Laura R. Serbus et al.   Annual Review of Genetics

Gene-drive in age-structured insect populations

(2008) Yunxin Huang et al.   Evolutionary Applications

The Population Genetics of Using Homing Endonuclease Genes in Vector and Pest Management

(2008) A. Deredec et al.   GENETICS

A Killer-Rescue system for self-limiting gene drive of anti-pathogen constructs

(2008) F. Gould et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Targeting the X Chromosome during Spermatogenesis Induces Y Chromosome Transmission Ratio Distortion and Early Dominant Embryo Lethality in Anopheles gambiae

(2008) Nikolai Windbichler et al.   PLoS Genetics