期刊
JOURNAL OF INSECT PHYSIOLOGY
卷 56, 期 10, 页码 1402-1413出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jinsphys.2010.05.022
关键词
Selfish genetic element; Mosquito; Malaria; Dengue; Pest; Medea; Population replacement; Maternal
资金
- NIH [5K02AG031915-02, 5RO1AG033410-02, 5RO1NS048396-05]
- Caltech Moore Foundation Center for Biological Circuit Design
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [DP1GM105377] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS048396] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG033410, K02AG031915] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP1OD003878] Funding Source: NIH RePORTER
Advances in insect transgenesis and our knowledge of insect physiology and genomics are making it possible to create transgenic populations of beneficial or pest insects that express novel traits There are contexts in which we may want the transgenes responsible for these traits to spread so that all individuals within a wild population carry them, a process known as population replacement. Transgenes of interest are unlikely to confer an overall fitness benefit on those who carry them Therefore, an essential component of any population replacement strategy is the presence of a drive mechanism that will ensure the spread of linked transgenes. We discuss contexts in which population replacement might be desirable and the requirements a drive system must satisfy to be both effective and safe We then describe the creation of synthetic Medea elements, the first selfish genetic elements synthesized de novo, with the capability of driving population replacement, in this case in Drosophila. The strategy used to create Drosophila Medea is applicable to a number of other insect species and the Medea system satisfies key requirements for scientific and social acceptance. Finally, we highlight several challenges to implementing population replacement in the wild. (C) 2010 Elsevier Ltd All rights reserved
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据