Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity

The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery

(2012) Craig E Thomas et al.   Expert Opinion on Drug Discovery

Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium-induced de- and hyperpolarization of neuronal mitochondria

(2012) Akos A. Gerencser et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cardiomyocytes derived from human pluripotent stem cells for drug screening

(2012) Naama Zeevi-Levin et al.   PHARMACOLOGY & THERAPEUTICS

Validation of an in vitro contractility assay using canine ventricular myocytes

(2012) A.R. Harmer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

(2011) HG Laverty et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment

(2011) Yama A Abassi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Stem Cells for Drug Screening

(2011) Rebecca R Laposa   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Usefulness of NT-Pro-BNP and Echocardiography in the Diagnosis of Subclinical Clozapine-Related Cardiotoxicity

(2011) Carlo Rostagno et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes

(2011) Thomas Force et al.   NATURE REVIEWS DRUG DISCOVERY

Cell death assays for drug discovery

(2011) Oliver Kepp et al.   NATURE REVIEWS DRUG DISCOVERY

Estimating the Risk of Drug-Induced Proarrhythmia Using Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes

(2011) Liang Guo et al.   TOXICOLOGICAL SCIENCES

Value of non-clinical cardiac repolarization assays in supporting the discovery and development of safer medicines

(2010) Jean-Pierre Valentin et al.   BRITISH JOURNAL OF PHARMACOLOGY

An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk

(2010) CE Pollard et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cardiotoxicity Associated with Targeting Kinase Pathways in Cancer

(2010) Howard R. Mellor et al.   TOXICOLOGICAL SCIENCES

The cardiotoxicity and myocyte damage caused by small molecule anticancer tyrosine kinase inhibitors is correlated with lack of target specificity

(2010) Brian B. Hasinoff   TOXICOLOGY AND APPLIED PHARMACOLOGY

Altered cytosolic Ca2+ dynamics in cultured Guinea pig cardiomyocytes as an in vitro model to identify potential cardiotoxicants

(2010) Jian-Yong Qian et al.   TOXICOLOGY IN VITRO

Dog left ventricular midmyocardial myocytes for assessment of drug-induced delayed repolarization: short-term variability and proarrhythmic potential

(2009) Najah Abi-Gerges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sunitinib-Induced Cardiotoxicity Is Mediated by Off-Target Inhibition of AMP-Activated Protein Kinase

(2009) Risto Kerkela et al.   CTS-Clinical and Translational Science

Cardionomics: a new integrative approach for screening cardiotoxicity of drug candidates

(2009) Judith K Gwathmey et al.   Expert Opinion on Drug Metabolism & Toxicology

Mitochondrial damage as death inducer in heart-derived H9c2 cells: more than one way for an early demise

(2009) Antonio Lax et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

ER stress in cardiovascular disease

(2009) Tetsuo Minamino et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiotoxicity of Anticancer Drugs: The Need for Cardio-Oncology and Cardio-Oncological Prevention

(2009) Adriana Albini et al.   JNCI-Journal of the National Cancer Institute

A framework to assess the translation of safety pharmacology data to humans

(2009) Jean-Pierre Valentin et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Glutathione peroxidase 1-deficient mice are more susceptible to doxorubicin-induced cardiotoxicity

(2008) Jinping Gao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

In Vitro Electrophysiological Drug Testing Using Human Embryonic Stem Cell Derived Cardiomyocytes

(2008) Oren Caspi et al.   STEM CELLS AND DEVELOPMENT

Effect of the Multitargeted Tyrosine Kinase Inhibitors Imatinib, Dasatinib, Sunitinib, and Sorafenib on Mitochondrial Function in Isolated Rat Heart Mitochondria and H9c2 Cells

(2008) Yvonne Will et al.   TOXICOLOGICAL SCIENCES

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES