Pro-inflammatory regulatory mechanism of C5a/C5aR pathway in GCRV-infected grass carp (Ctenopharyngodon idella)

Identification and immune responses of thrombocytes in bacterial and viral infections in grass carp (Ctenopharyngodon idella)

(2022) Yan He et al.   FISH & SHELLFISH IMMUNOLOGY

Role of the C5a-C5a receptor axis in the inflammatory responses of the lungs after experimental polytrauma and hemorrhagic shock

(2021) Shinjini Chakraborty et al.   Scientific Reports

Inhibition of complement C5a receptor protects lung cells and tissues against lipopolysaccharide-induced injury via blocking pyroptosis

(2021) Renying Wang et al.   Aging-US

Functional characterization of an interleukin 20 like homologue in grass carp Ctenopharyngodon idella

(2021) Zeinab Hassan et al.   FISH & SHELLFISH IMMUNOLOGY

Elevated Expression Levels of Lung Complement Anaphylatoxin, Neutrophil Chemoattractant Chemokine IL-8, and RANTES in MERS-CoV-Infected Patients: Predictive Biomarkers for Disease Severity and Mortality

(2021) Maaweya E. Hamed et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Depletion of EREG enhances the osteo/dentinogenic differentiation ability of dental pulp stem cells via the p38 MAPK and Erk pathways in an inflammatory microenvironment

(2021) Ran Ran et al.   BMC Oral Health

Giardia duodenalis Induces Proinflammatory Cytokine Production in Mouse Macrophages via TLR9-Mediated p38 and ERK Signaling Pathways

(2021) Xudong Pu et al.   Frontiers in Cell and Developmental Biology

Complement C5a and Clinical Markers as Predictors of COVID-19 Disease Severity and Mortality in a Multi-Ethnic Population

(2021) Farhan S. Cyprian et al.   Frontiers in Immunology

Interleukin-17 suppresses grass carp reovirus infection in Ctenopharyngodon idellus kidney cells by activating NF-κB signaling

(2020) Yunshan Zhang et al.   AQUACULTURE

Studies on the clinical symptoms, virus distribution, and mRNA expression of several antiviral immunity-related genes in grass carp after infection with genotype II grass carp reovirus

(2020) Minglin Wu et al.   ARCHIVES OF VIROLOGY

Ginsenoside Rg3 inhibits grass carp reovirus replication in grass carp ovarian epithelial cells

(2020) Jing Dai et al.   MICROBIAL PATHOGENESIS

Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis

(2020) Julien Carvelli et al.   NATURE

Targeting Complement C5a Receptor 1 for the Treatment of Immunosuppression in Sepsis

(2020) Oliver Sommerfeld et al.   MOLECULAR THERAPY

Roadblocks and fast tracks: How RNA binding proteins affect the viral RNA journey in the cell

(2020) Erika Girardi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Autophagy Inhibits Grass Carp Reovirus (GCRV) Replication and Protects Ctenopharyngodon idella Kidney (CIK) Cells from Excessive Inflammatory Responses after GCRV Infection

(2020) Pengfei Chu et al.   Biomolecules

Different resistance potential to reovirus in grass carp (Ctenopharyngodon idella) populations and their immune characteristics

(2020) Hongquan Wang et al.   AQUACULTURE INTERNATIONAL

Grass carp Mre11A activates IFN 1 response by targeting STING to defend against GCRV infection

(2020) Xiaowen Xu et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Complement factors C3a and C5a mimick a proinflammatory microenvironment and increase HBV IGRA sensitivity

(2019) Katharina Bröker et al.   Journal of Translational Medicine

Comparative study of the immunoprotective effect of two grass carp-sourced Bacillus subtilis spore-based vaccines against grass carp reovirus

(2019) Dan-Dan Chen et al.   AQUACULTURE

Comparison of the blood parameters and histopathology between grass carp infected with a virulent and avirulent isolates of genotype II grass carp reovirus

(2019) Yafang Tang et al.   MICROBIAL PATHOGENESIS

Anaphylatoxin C5a induces inflammation and reduces insulin sensitivity by activating TLR4/NF-kB/PI3K signaling pathway in 3T3-L1 adipocytes

(2018) Xin-Yan Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

C5a receptor1 inhibition alleviates influenza virus-induced acute lung injury

(2018) Nianping Song et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Identification, characterisation and preliminary functional analysis of IRAK-M in grass carp (Ctenopharyngodon idella)

(2018) Pengfei Chu et al.   FISH & SHELLFISH IMMUNOLOGY

Molecular cloning and expression analysis of coagulation factor VIII and plasminogen involved in immune response to GCRV, and immunity activity comparison of grass carp Ctenopharyngodon idella with different viral resistance

(2018) Hongquan Wang et al.   FISH & SHELLFISH IMMUNOLOGY

Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) in fish: current knowledge and future perspectives

(2017) Shan Nan Chen et al.   IMMUNOLOGY

Teleost-Specific TLR19 Localizes to Endosome, Recognizes dsRNA, Recruits TRIF, Triggers both IFN and NF-κB Pathways, and Protects Cells from Grass Carp Reovirus Infection

(2017) Jianfei Ji et al.   JOURNAL OF IMMUNOLOGY

Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors

(2017) Caroline S. Colley et al.   mAbs

Repression of SUMOylation pathway by grass carp reovirus contributes to the upregulation of PKR in an IFN-independent manner

(2017) Fei Yu et al.   Oncotarget

MDA5 Induces a Stronger Interferon Response than RIG-I to GCRV Infection through a Mechanism Involving the Phosphorylation and Dimerization of IRF3 and IRF7 in CIK Cells

(2017) Quanyuan Wan et al.   Frontiers in Immunology

TNF-α is involved in apoptosis triggered by grass carp reovirus infection in vitro

(2016) Jianfei Lu et al.   FISH & SHELLFISH IMMUNOLOGY

C5a Induces the Synthesis of IL-6 and TNF-α in Rat Glomerular Mesangial Cells through MAPK Signaling Pathways

(2016) Mingde Ji et al.   PLoS One

C5a/C5aR pathway is essential for up-regulating SphK1 expression through p38-MAPK activation in acute liver failure

(2016) Yan-Chang Lei et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Grass carp reovirus induces apoptosis and oxidative stress in grass carp (Ctenopharyngodon idellus) kidney cell line

(2014) Rui Jia et al.   VIRUS RESEARCH

Trunk kidney of grass carp (Ctenopharyngodon idella) mediates immune responses against GCRV and viral/bacterial PAMPs in vivo and in vitro

(2013) Lijun Chen et al.   FISH & SHELLFISH IMMUNOLOGY

Identification and genomic characterization of a novel fish reovirus, Hubei grass carp disease reovirus, isolated in 2009 in China

(2013) Y. Fan et al.   JOURNAL OF GENERAL VIROLOGY

The Harmful Role of C5a on Innate Immunity in Sepsis

(2010) Peter A. Ward   Journal of Innate Immunity

In Human Macrophages the Complement Component C5a Induces the Expression of Oncostatin M via AP-1 Activation

(2008) Stefan P. Kastl et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

C5a Receptor Mediates Neutrophil Activation and ANCA-Induced Glomerulonephritis

(2008) A. Schreiber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Functional roles for C5a receptors in sepsis

(2008) Daniel Rittirsch et al.   NATURE MEDICINE