Role of the C5a-C5a receptor axis in the inflammatory responses of the lungs after experimental polytrauma and hemorrhagic shock

Differential effects of anaphylatoxin C5a on antigen presenting cells, roles for C5aR1 and C5aR2

(2019) Anouk Zaal et al.   IMMUNOLOGY LETTERS

Airway and alveolar epithelial cells in culture

(2019) Pieter S. Hiemstra et al.   EUROPEAN RESPIRATORY JOURNAL

Generation of complement molecular complex C5b-9 (C5b-9) in response to poly-traumatic hemorrhagic shock and evaluation of C5 cleavage inhibitors in non-human primates

(2018) R. Madelaine Paredes et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hemorrhagic shock drives glycocalyx, barrier and organ dysfunction early after polytrauma

(2018) Rebecca Halbgebauer et al.   JOURNAL OF CRITICAL CARE

Innate immune responses to trauma

(2018) Markus Huber-Lang et al.   NATURE IMMUNOLOGY

Role of Hemorrhagic Shock in Experimental Polytrauma

(2018) Stephanie Denk et al.   SHOCK

Human lung epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and future directions

(2018) Pieter S. Hiemstra et al.   TOXICOLOGY IN VITRO

ATP is stored in lamellar bodies to activate vesicular P2X4in an autocrine fashion upon exocytosis

(2017) Giorgio Fois et al.   JOURNAL OF GENERAL PHYSIOLOGY

Complement C5a Functions as a Master Switch for the pH Balance in Neutrophils Exerting Fundamental Immunometabolic Effects

(2017) Stephanie Denk et al.   JOURNAL OF IMMUNOLOGY

The renaissance of complement therapeutics

(2017) Daniel Ricklin et al.   Nature Reviews Nephrology

The C5a/C5aR1 axis controls the development of experimental allergic asthma independent of LysM-expressing pulmonary immune cells

(2017) Anna V. Wiese et al.   PLoS One

Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model ofEscherichia colisepsis

(2017) Ravi Shankar Keshari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair

(2017) Anna Kovtun et al.   Scientific Reports

C5L2, the Second C5a Anaphylatoxin Receptor, Suppresses LPS-Induced Acute Lung Injury

(2016) Ruobing Wang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Global burden of diseases, injuries, and risk factors for young people's health during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2016) Ali H Mokdad et al.   LANCET

Complement therapeutic strategies in trauma, hemorrhagic shock and systemic inflammation – closing Pandora’s box?

(2016) Markus Huber-Lang et al.   SEMINARS IN IMMUNOLOGY

Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer

(2015) Laure Yatime et al.   Nature Communications

Crucial Role of IL1beta and C3a in the In Vitro-Response of Multipotent Mesenchymal Stromal Cells to Inflammatory Mediators of Polytrauma

(2015) Nina-Emily Hengartner et al.   PLoS One

The C5a Anaphylatoxin Receptor (C5aR1) Protects againstListeria monocytogenesInfection by Inhibiting Type 1 IFN Expression

(2014) Daniel G. Calame et al.   JOURNAL OF IMMUNOLOGY

Complement mediates a primed inflammatory response after traumatic lung injury

(2014) J. Jason Hoth et al.   Journal of Trauma and Acute Care Surgery

Deuterium Oxide Dilution: A Novel Method to Study Apical Water Layers and Transepithelial Water Transport

(2013) Daniel Neubauer et al.   ANALYTICAL CHEMISTRY

Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury

(2013) Markus Bosmann et al.   FASEB JOURNAL

A Novel C5a-neutralizing Mirror-image (l-)Aptamer Prevents Organ Failure and Improves Survival in Experimental Sepsis

(2013) Kai Hoehlig et al.   MOLECULAR THERAPY

The acute respiratory distress syndrome

(2012) Michael A. Matthay et al.   JOURNAL OF CLINICAL INVESTIGATION

Early Complementopathy After Multiple Injuries in Humans

(2012) Anne-Maud Burk et al.   SHOCK

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Fusion-Activated Ca2+ Entry: An “Active Zone” of Elevated Ca2+ during the Postfusion Stage of Lamellar Body Exocytosis in Rat Type II Pneumocytes

(2010) Pika Miklavc et al.   PLoS One

Functional roles for C5a receptors in sepsis

(2008) Daniel Rittirsch et al.   NATURE MEDICINE

Myeloperoxidase modulates lung epithelial responses to pro-inflammatory agents

(2007) A. Haegens et al.   EUROPEAN RESPIRATORY JOURNAL