LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1

(2015) Purna A. Joshi et al.   Stem Cell Reports

RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization

(2014) Gina Chia-Yi Chu et al.   ENDOCRINE-RELATED CANCER

Improvement in Low-Homology Template-Based Modeling by Employing a Model Evaluation Method with Focus on Topology

(2014) Wentao Dai et al.   PLoS One

GPR116, an Adhesion G-Protein-Coupled Receptor, Promotes Breast Cancer Metastasis via the G q-p63RhoGEF-Rho GTPase Pathway

(2013) X. Tang et al.   CANCER RESEARCH

GPR48, a poor prognostic factor, promotes tumor metastasis and activates β-catenin/TCF signaling in colorectal cancer

(2013) Jinhua Wu et al.   CARCINOGENESIS

Structural basis for R-spondin recognition by LGR4/5/6 receptors

(2013) D. Wang et al.   GENES & DEVELOPMENT

Lgr4/Gpr48 Negatively Regulates TLR2/4-associated Pattern Recognition and Innate Immunity by Targeting CD14 Expression

(2013) Bing Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multi-functional norrin is a ligand for the LGR4 receptor

(2013) C. Deng et al.   JOURNAL OF CELL SCIENCE

Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation

(2013) Sunao Takeshita et al.   JOURNAL OF CLINICAL INVESTIGATION

Advances in the Regulation of Osteoclasts and Osteoclast Functions

(2013) B.F. Boyce   JOURNAL OF DENTAL RESEARCH

Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits

(2013) Unnur Styrkarsdottir et al.   NATURE

Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch

(2013) Jiqiu Wang et al.   NATURE CELL BIOLOGY

Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus

(2013) Stefan Kiechl et al.   NATURE MEDICINE

Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2

(2013) Ying Wang et al.   STEM CELLS

Caffeic acid 3,4-dihydroxy-phenethyl ester suppresses receptor activator of NF-κB ligand-induced osteoclastogenesis and prevents ovariectomy-induced bone loss through inhibition of mitogen-activated protein kinase/activator protein 1 and Ca2+-nuclear fact

(2012) Xian Wu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab

(2012) David L. Lacey et al.   NATURE REVIEWS DRUG DISCOVERY

Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses

(2011) Z. Zhang et al.   BLOOD

Akt Induces Osteoclast Differentiation through Regulating the GSK3 /NFATc1 Signaling Cascade

(2011) J. B. Moon et al.   JOURNAL OF IMMUNOLOGY

RANKL/RANK—beyond bones

(2011) Reiko Hanada et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling

(2011) Wei Tan et al.   NATURE

Accelerating Protein Docking in ZDOCK Using an Advanced 3D Convolution Library

(2011) Brian G. Pierce et al.   PLoS One

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway

(2010) Gerhard Krönke et al.   ARTHRITIS AND RHEUMATISM

c-Src-mediated Phosphorylation of Thyroid Hormone Receptor-interacting Protein 6 (TRIP6) Promotes Osteoclast Sealing Zone Formation

(2010) Brooke K. McMichael et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-mediated NF-κB and MAPK signaling pathways

(2010) Chenghai Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis

(2010) Eva Gonzalez-Suarez et al.   NATURE

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

(2010) Daniel Schramek et al.   NATURE

What old means to bone

(2010) Stavros C. Manolagas et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation of bone formation and remodeling by G-protein-coupled receptor 48

(2009) J. Luo et al.   DEVELOPMENT

Central control of fever and female body temperature by RANKL/RANK

(2009) Reiko Hanada et al.   NATURE

Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2

(2008) J. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA