Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2

Lgr4-mediated Wnt/ -catenin signaling in peritubular myoid cells is essential for spermatogenesis

(2013) Y. Qian et al.   DEVELOPMENT

Lgr4Gene Deficiency Increases Susceptibility and Severity of Dextran Sodium Sulfate-induced Inflammatory Bowel Disease in Mice

(2013) Shijie Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lgr5-Expressing Cells Are Sufficient and Necessary for Postnatal Mammary Gland Organogenesis

(2013) Vicki Plaks et al.   Cell Reports

A Mammary Stem Cell Population Identified and Characterized in Late Embryogenesis Reveals Similarities to Human Breast Cancer

(2012) Benjamin T. Spike et al.   Cell Stem Cell

β-Catenin–SOX2 signaling regulates the fate of developing airway epithelium

(2012) Shuichi Hashimoto et al.   JOURNAL OF CELL SCIENCE

Developmental stage-specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland

(2012) Karin E de Visser et al.   JOURNAL OF PATHOLOGY

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Haploinsufficiency in the Prometastasis Kiss1 Receptor Gpr54 Delays Breast Tumor Initiation, Progression, and Lung Metastasis

(2011) S.-G. Cho et al.   CANCER RESEARCH

Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice

(2011) Katrin Arnold et al.   Cell Stem Cell

Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo

(2011) Roxana C Mustata et al.   EMBO REPORTS

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

(2011) Andrei Glinka et al.   EMBO REPORTS

GPR48 Increases Mineralocorticoid Receptor Gene Expression

(2011) J. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conditional Knockout of Lgr4 Leads to Impaired Ductal Elongation and Branching Morphogenesis in Mouse Mammary Glands

(2011) K. Oyama et al.   Sexual Development

Effects of estrogen on the proportion of stem cells in the breast

(2010) Bruno M. Simões et al.   BREAST CANCER RESEARCH AND TREATMENT

Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture

(2010) Yi Arial Zeng et al.   Cell Stem Cell

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

(2010) H. J. Snippert et al.   SCIENCE

G protein-coupled receptor 48 upregulates estrogen receptor   expression via cAMP/PKA signaling in the male reproductive tract

(2009) X.-Y. Li et al.   DEVELOPMENT

Regulation of bone formation and remodeling by G-protein-coupled receptor 48

(2009) J. Luo et al.   DEVELOPMENT

A directional Wnt/ -catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the Xenopus retina

(2009) M. Agathocleous et al.   DEVELOPMENT

Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice

(2009) Ryo Yamashita et al.   DEVELOPMENTAL DYNAMICS

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Phenotypic and Functional Characterization of Human Mammary Stem/Progenitor Cells in Long Term Culture

(2009) Devaveena Dey et al.   PLoS One

The Wnt Co-Receptor Lrp6 Is Required for Normal Mouse Mammary Gland Development

(2009) Charlotta Lindvall et al.   PLoS One

The Wnt Receptor, Lrp5, Is Expressed by Mouse Mammary Stem Cells and Is Required to Maintain the Basal Lineage

(2009) Nisha M. Badders et al.   PLoS One

Smad, PI3K/Akt, and Wnt-Dependent Signaling Pathways Are Involved in BMP-4-Induced ESC Self-Renewal

(2009) Min Young Lee et al.   STEM CELLS

Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment

(2008) Toula Bouras et al.   Cell Stem Cell

Collective Epithelial Migration and Cell Rearrangements Drive Mammary Branching Morphogenesis

(2008) Andrew J. Ewald et al.   DEVELOPMENTAL CELL

Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4

(2008) Yasuaki Mohri et al.   DEVELOPMENTAL DYNAMICS

Inactivation of G-protein-coupled Receptor 48 (Gpr48/Lgr4) Impairs Definitive Erythropoiesis at Midgestation through Down-regulation of the ATF4 Signaling Pathway

(2008) Huiping Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lgr5 marks cycling, yet long-lived, hair follicle stem cells

(2008) Viljar Jaks et al.   NATURE GENETICS

Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2

(2008) J. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA