Lgr4/Gpr48 Negatively Regulates TLR2/4-associated Pattern Recognition and Innate Immunity by Targeting CD14 Expression

siRNA targeting mCD14 inhibits TNF-α, MIP-2, and IL-6 secretion and NO production from LPS-induced RAW264.7 cells

(2011) Ming Lei et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo

(2011) Roxana C Mustata et al.   EMBO REPORTS

Insulin/IGF-I Regulation of Necdin and Brown Adipocyte Differentiation Via CREB- and FoxO1-Associated Pathways

(2011) Aaron M. Cypess et al.   ENDOCRINOLOGY

GPR48 Increases Mineralocorticoid Receptor Gene Expression

(2011) J. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cAMP Modulates Macrophage Development by Suppressing M-CSF-Induced MAPKs Activation

(2010) Ning Zhu et al.   Cellular & Molecular Immunology

GPR48-Induced keratinocyte proliferation occurs through HB-EGF mediated EGFR transactivation

(2010) Zhenlian Wang et al.   FEBS LETTERS

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

G protein-coupled receptor 48 upregulates estrogen receptor   expression via cAMP/PKA signaling in the male reproductive tract

(2009) X.-Y. Li et al.   DEVELOPMENT

Regulation of bone formation and remodeling by G-protein-coupled receptor 48

(2009) J. Luo et al.   DEVELOPMENT

Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice

(2009) Ryo Yamashita et al.   DEVELOPMENTAL DYNAMICS

Silencing cAMP-response Element-binding Protein (CREB) IdentifiesCYR61as a Tumor Suppressor Gene in Melanoma

(2009) Andrey S. Dobroff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inducible cAMP Early Repressor (ICER) and Brain Functions

(2009) Gilyana Borlikova et al.   MOLECULAR NEUROBIOLOGY

Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4

(2008) Yasuaki Mohri et al.   DEVELOPMENTAL DYNAMICS

Inactivation of G-protein-coupled Receptor 48 (Gpr48/Lgr4) Impairs Definitive Erythropoiesis at Midgestation through Down-regulation of the ATF4 Signaling Pathway

(2008) Huiping Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2

(2008) J. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA