Integrative bioinformatics analysis to screen key genes and signalling pathways related to ferroptosis in obesity

Adipose tissue macrophage-derived exosomes induce ferroptosis via glutathione synthesis inhibition by targeting SLC7A11 in obesity-induced cardiac injury

(2022) Xin Zhao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Research Progress of Ferroptosis in Adiposity-Based Chronic Disease (ABCD)

(2022) Huijun Du et al.   Oxidative Medicine and Cellular Longevity

Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer

(2022) Shumin Ouyang et al.   Redox Biology

The timing of adiposity and changes in the life course on the risk of cancer

(2022) Zhe Fang et al.   CANCER AND METASTASIS REVIEWS

An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload

(2022) Magdalene K. Ameka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ferroptosis and Its Role in Chronic Diseases

(2022) Wenli Hu et al.   Cells

Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity

(2021) Zhuzhen Zhang et al.   Cell Metabolism

Aflibercept, a VEGF (Vascular Endothelial Growth Factor)-Trap, Reduces Vascular Permeability and Stroke-Induced Brain Swelling in Obese Mice

(2021) Il-doo Kim et al.   STROKE

Iron Overload Protects from Obesity by Ferroptosis

(2021) Wan Ma et al.   Foods

Mechanisms and pharmacological applications of ferroptosis: a narrative review

(2021) Jing-Jing Zhang et al.   Annals of Translational Medicine

Regulation of adipose tissue inflammation by interleukin 6

(2020) Myoung Sook Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estrogen receptor-regulated SOCS3 modulation via JAK2/STAT3 pathway is involved in BPF-induced M1 polarization of macrophages

(2020) Mingjie Shi et al.   TOXICOLOGY

Dysregulation of microRNA-125a contributes to obesity-associated insulin resistance and dysregulates lipid metabolism in mice

(2020) Rui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Obesity in adults: a clinical practice guideline

(2020) Sean Wharton et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

A TRAIL-TL1A Paracrine Network Involving Adipocytes, Macrophages and lymphocytes Induces Adipose Tissue Dysfunction Downstream of E2F1 in Human Obesity

(2020) Nitzan Maixner et al.   DIABETES

STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity

(2020) Aaron R. Cox et al.   DIABETES

Targeting miR-10a-5p/IL-6R axis for reducing IL-6-induced cartilage cell ferroptosis

(2020) Sheng Bin et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

VEGF in Signaling and Disease: Beyond Discovery and Development

(2019) Rajendra S. Apte et al.   CELL

STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth

(2019) Chunyan Zhang et al.   Cell Metabolism

A combination of Omega-3 PUFAs and COX inhibitors: A novel strategy to manage obesity-linked dyslipidemia and adipose tissue inflammation

(2019) Viswanathan Saraswathi et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Gain of Metabolic Benefit with Ablation of miR-149-3p from Subcutaneous Adipose Tissue in Diet-Induced Obese Mice

(2019) Shasha Zheng et al.   Molecular Therapy-Nucleic Acids

Targeted inhibition of CD74 attenuates adipose COX-2-MIF-mediated M1 macrophage polarization and retards obesity-related adipose tissue inflammation and insulin resistance

(2018) Pei-Chi Chan et al.   CLINICAL SCIENCE

Global Economic Burden of Diabetes in Adults: Projections From 2015 to 2030

(2018) Christian Bommer et al.   DIABETES CARE

MicroRNA-29c inhibits proliferation and promotes apoptosis in non-small cell lung cancer cells by targeting VEGFA

(2018) Shijuan Zhan et al.   Molecular Medicine Reports

Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease

(2018) Mario Masarone et al.   Oxidative Medicine and Cellular Longevity

The Association of Plasma Levels of Mir-34A and Mir-149 with Obesity and Insulin Resistance in Obese Children and Adolescents

(2018) F Ahmadpour   Acta Endocrinologica-Bucharest

Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial

(2018) Anne-Sophie Wedell-Neergaard et al.   Cell Metabolism

Obesity-induced activation of JunD promotes myocardial lipid accumulation and metabolic cardiomyopathy

(2018) Sarah Costantino et al.   EUROPEAN HEART JOURNAL

NF-κB-miR15a-bFGF/VEGFA axis contributes to the impaired angiogenic capacity of BM-MSCs in high fat diet-fed mice

(2017) Zhuoli Zhu et al.   Molecular Medicine Reports

On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations

(2017) A. Qasim et al.   Obesity Reviews

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner

(2017) D Chen et al.   ONCOGENE

Cucurbitacin E reduces obesity and related metabolic dysfunction in mice by targeting JAK-STAT5 signaling pathway

(2017) Munazza Murtaza et al.   PLoS One

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

(2016) Ajaikumar B Kunnumakkara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Importance of adipocyte cyclooxygenase-2 and prostaglandin E2–prostaglandin E receptor 3 signaling in the development of obesity-induced adipose tissue inflammation and insulin resistance

(2016) Pei-Chi Chan et al.   FASEB JOURNAL

Impact of Adiposity on Incident Hypertension Is Modified by Insulin Resistance in AdultsNovelty and Significance

(2015) Tao Zhang et al.   HYPERTENSION

Bardoxolone methyl prevents insulin resistance and the development of hepatic steatosis in mice fed a high-fat diet

(2015) Danielle Camer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Iron homeostasis: a new job for macrophages in adipose tissue?

(2015) Merla J. Hubler et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity

(2015) Yuhei Nishimura et al.   Frontiers in Pharmacology

IL-6 Strikes a Balance in Metabolic Inflammation

(2014) Anthony J. Covarrubias et al.   Cell Metabolism

Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease

(2014) Nathalie Esser et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Vascular rarefaction mediates whitening of brown fat in obesity

(2014) Ippei Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

COX-1 (PTGS1) and COX-2 (PTGS2) polymorphisms, NSAID interactions, and risk of colon and rectal cancers in two independent populations

(2013) Karen W. Makar et al.   CANCER CAUSES & CONTROL

Targeting the Circulating MicroRNA Signature of Obesity

(2013) F. J. Ortega et al.   CLINICAL CHEMISTRY

Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance

(2013) S. J. Priceman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Obesity Epidemic and Its Impact on Hypertension

(2012) Thang Nguyen et al.   CANADIAN JOURNAL OF CARDIOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Dichotomous effects of VEGF-A on adipose tissue dysfunction

(2012) K. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

(2011) Goodarz Danaei et al.   LANCET

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS