Aflibercept, a VEGF (Vascular Endothelial Growth Factor)-Trap, Reduces Vascular Permeability and Stroke-Induced Brain Swelling in Obese Mice

High fructose diet-induced obesity worsens post-ischemic brain injury in the hippocampus of female rats

(2020) P. A. Pérez-Corredor et al.   NUTRITIONAL NEUROSCIENCE

Vascular Endothelial Growth Factor 165-Binding Heparan Sulfate Promotes Functional Recovery From Cerebral Ischemia

(2020) Su Jing Chan et al.   STROKE

Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies

(2020) Surojit Paul et al.   EXPERIMENTAL NEUROLOGY

Preventative, but not post-stroke, inhibition of CD36 attenuates brain swelling in hyperlipidemic stroke

(2019) Eunhee Kim et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Intravenous Glibenclamide Reduces Lesional Water Uptake in Large Hemispheric Infarction

(2019) Pongpat Vorasayan et al.   STROKE

Promiscuous Chemokine Antagonist (BKT130) Suppresses Laser-Induced Choroidal Neovascularization by Inhibition of Monocyte Recruitment

(2019) Shira Hagbi-Levi et al.   Journal of Immunology Research

The effect of angiopoietin-1 upregulation on the outcome of acute ischaemic stroke in rodent models: A meta-analysis

(2019) Joseph V Moxon et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Elevated blood glucose is associated with aggravated brain edema in acute stroke

(2019) Gabriel Broocks et al.   JOURNAL OF NEUROLOGY

Reduction in Cerebrospinal Fluid Volume as an Early Quantitative Biomarker of Cerebral Edema After Ischemic Stroke

(2019) Rajat Dhar et al.   STROKE

A new era for stroke therapy: Integrating neurovascular protection with optimal reperfusion

(2018) Ligen Shi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

VEGF regulates hippocampal neurogenesis and reverses cognitive deficits in immature rats after status epilepticus through the VEGF R2 signaling pathway

(2017) Wei Han et al.   EPILEPSY & BEHAVIOR

Inhibition of VEGF Signaling Reduces Diabetes-Exacerbated Brain Swelling, but Not Infarct Size, in Large Cerebral Infarction in Mice

(2017) Eunhee Kim et al.   Translational Stroke Research

Angiopoietin-2-induced blood–brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling

(2016) Stefanie Gurnik et al.   ACTA NEUROPATHOLOGICA

Aflibercept, bevacizumab and ranibizumab prevent glucose-induced damage in human retinal pericytes in vitro, through a PLA2/COX-2/VEGF-A pathway

(2015) Giovanni Giurdanella et al.   BIOCHEMICAL PHARMACOLOGY

Inhibitory Effect of Topical Aflibercept on Corneal Neovascularization in Rabbits

(2015) Yi-Ryeung Park et al.   CORNEA

Molecular pathophysiology of cerebral edema

(2015) Jesse A Stokum et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Delayed Inhibition of VEGF Signaling after Stroke Attenuates Blood-Brain Barrier Breakdown and Improves Functional Recovery in a Comorbidity-Dependent Manner

(2015) P. Reeson et al.   JOURNAL OF NEUROSCIENCE

Aflibercept, Bevacizumab, or Ranibizumab for Diabetic Macular Edema

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

Effect of aflibercept in insufficient responders to prior anti-VEGF therapy in neovascular AMD

(2014) Heidi Fassnacht-Riederle et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Cerebral Neovascularization in Diabetes: Implications for Stroke Recovery and beyond

(2014) Adviye Ergul et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Deregulation of inflammatory response in the diabetic condition is associated with increased ischemic brain injury

(2014) Eunhee Kim et al.   Journal of Neuroinflammation

Brain Edema Predicts Outcome After Nonlacunar Ischemic Stroke

(2014) Thomas W.K. Battey et al.   STROKE

NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis

(2013) A. Fantin et al.   BLOOD

Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer

(2013) Sampurna Chatterjee et al.   JOURNAL OF CLINICAL INVESTIGATION

VEGF-releasing biodegradable nanospheres administered by craniotomy: A novel therapeutic approach in the APP/Ps1 mouse model of Alzheimer's disease

(2013) Enara Herrán et al.   JOURNAL OF CONTROLLED RELEASE

Vascular Endothelial Growth Factor Promotes Pericyte Coverage of Brain Capillaries, Improves Cerebral Blood Flow During Subsequent Focal Cerebral Ischemia, and Preserves the Metabolic Penumbra

(2013) Anil Zechariah et al.   STROKE

VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival

(2013) Piotr Religa et al.   Scientific Reports

Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab

(2012) Nicholas Papadopoulos et al.   ANGIOGENESIS

Effect of VEGF and VEGF Trap on vascular endothelial cell signaling in tumors

(2011) Wiem Lassoued et al.   CANCER BIOLOGY & THERAPY

Neurological complications of acute ischaemic stroke

(2011) Joyce S Balami et al.   LANCET NEUROLOGY

Intravenous aflibercept for treatment of recurrent symptomatic malignant ascites in patients with advanced ovarian cancer: a phase 2, randomised, double-blind, placebo-controlled study

(2011) Walter H Gotlieb et al.   LANCET ONCOLOGY

Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after focal cerebral ischemia via mechanisms involving anti-inflammatory actions

(2011) Josephine Herz et al.   NEUROBIOLOGY OF DISEASE

Preventing increased blood pressure in the obese Zucker rat improves severity of stroke

(2010) Jessica M. Osmond et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Increased Brain Microvascular MMP-9 and Incidence of Haemorrhagic Transformation in Obese Mice after Experimental Stroke

(2009) Barry W McColl et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CD36/Fatty Acid Translocase, An Inflammatory Mediator, Is Involved in Hyperlipidemia-Induced Exacerbation in Ischemic Brain Injury

(2008) E. Kim et al.   JOURNAL OF NEUROSCIENCE

Aggravation of infarct formation by brain swelling in a large territorial stroke: a target for neuroprotection?

(2008) Maureen Walberer et al.   JOURNAL OF NEUROSURGERY

Blood-brain barrier tight junction permeability and ischemic stroke

(2008) Karin E. Sandoval et al.   NEUROBIOLOGY OF DISEASE