High-throughput screening of novel TFEB agonists in protecting against Acetaminophen-Induced Liver Injury in Mice

Narirutin activates TFEB (transcription factor EB) to protect against Acetaminophen-induced liver injury by targeting PPP3/calcineurin

(2023) Zhiyuan Fang et al.   Autophagy

Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease

(2023) Annabelle S Chidiac et al.   Expert Opinion on Drug Metabolism & Toxicology

Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice

(2021) Nga T. Nguyen et al.   ARCHIVES OF TOXICOLOGY

Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol‐impaired TFEB and liver injury in mice

(2021) Xiaojuan Chao et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Dual roles of p62/SQSTM1 in the injury and recovery phases of acetaminophen-induced liver injury in mice

(2021) Hui Qian et al.   Acta Pharmaceutica Sinica B

Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls

(2021) Hartmut Jaeschke et al.   Acta Pharmaceutica Sinica B

Role and Mechanisms of Mitophagy in Liver Diseases

(2020) Xiaowen Ma et al.   Cells

The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB

(2020) Zeyuan Zhang et al.   Autophagy

Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice

(2019) Hua Wang et al.   Redox Biology

Impaired TFEB-mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-induced Liver Injury and Steatosis in Mice

(2018) Xiaojuan Chao et al.   GASTROENTEROLOGY

Role and mechanisms of autophagy in acetaminophen-induced liver injury

(2018) Xiaojuan Chao et al.   LIVER INTERNATIONAL

Modulating NRF2 in Disease: Timing Is Everything

(2018) Matthew Dodson et al.   Annual Review of Pharmacology and Toxicology

Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity

(2017) Kuo Du et al.   FOOD AND CHEMICAL TOXICOLOGY

Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice

(2016) Hong-Min Ni et al.   JOURNAL OF HEPATOLOGY

p62/Sequestosome-1 Is Indispensable for Maturation and Stabilization of Mallory-Denk Bodies

(2016) Pooja Lahiri et al.   PLoS One

Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice

(2015) Jessica A. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Taurine zinc solid dispersions attenuate doxorubicin-induced hepatotoxicity and cardiotoxicity in rats

(2015) Yu Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy

(2014) Hong-Min Ni et al.   JOURNAL OF HEPATOLOGY

Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase

(2014) Kuo Du et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver

(2013) Hong-Min Ni et al.   Redox Biology

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

(2012) Hartmut Jaeschke et al.   DRUG METABOLISM REVIEWS

Liver-Specific Loss of Atg5 Causes Persistent Activation of Nrf2 and Protects Against Acetaminophen-Induced Liver Injury

(2012) Hong-Min Ni et al.   TOXICOLOGICAL SCIENCES

Endogenous Interleukin-4 Regulates Glutathione Synthesis Following Acetaminophen-Induced Liver Injury in Mice

(2011) Pauline M. Ryan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Activation of autophagy protects against acetaminophen-induced hepatotoxicity

(2011) Hong-Min Ni et al.   HEPATOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice

(2010) Adeline YL Lim et al.   BMC Pharmacology & Toxicology

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine

(2009) Chieko Saito et al.   HEPATOLOGY