Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice

A mitochondrial journey through acetaminophen hepatotoxicity

(2020) Anup Ramachandran et al.   FOOD AND CHEMICAL TOXICOLOGY

Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice

(2020) Nga T. Nguyen et al.   TOXICOLOGY LETTERS

Acetaminophen Hepatotoxicity

(2019) Anup Ramachandran et al.   SEMINARS IN LIVER DISEASE

Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice

(2019) Hua Wang et al.   Redox Biology

4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes

(2018) JY Akakpo et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Role and mechanisms of autophagy in acetaminophen-induced liver injury

(2018) Xiaojuan Chao et al.   LIVER INTERNATIONAL

The Regulation of JNK Signaling Pathways in Cell Death through the Interplay with Mitochondrial SAB and Upstream Post-Translational Effects

(2018) Sanda Win et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity

(2017) Kuo Du et al.   FOOD AND CHEMICAL TOXICOLOGY

Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice

(2016) Hong-Min Ni et al.   JOURNAL OF HEPATOLOGY

Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients

(2015) Hartmut Jaeschke   DIGESTIVE DISEASES

Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver

(2015) Jiangting Hu et al.   TOXICOLOGICAL SCIENCES

Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes

(2015) Yuchao Xie et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A direct comparison of methods used to measure oxidized glutathione in biological samples: 2-vinylpyridine andN-ethylmaleimide

(2015) Mitchell R. Mcgill et al.   TOXICOLOGY MECHANISMS AND METHODS

A direct comparison of methods used to measure oxidized glutathione in biological samples: 2-vinylpyridine andN-ethylmaleimide

(2015) Mitchell R. Mcgill et al.   TOXICOLOGY MECHANISMS AND METHODS

Acetaminophen hepatotoxicity: an updated review

(2014) Elizabeth M. Lancaster et al.   ARCHIVES OF TOXICOLOGY

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

(2013) Mitchell R. McGill et al.   PHARMACEUTICAL RESEARCH

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications

(2013) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver

(2013) Hong-Min Ni et al.   Redox Biology

Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

(2012) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Acetaminophen-cysteine adducts during therapeutic dosing and following overdose

(2011) Kennon J Heard et al.   BMC GASTROENTEROLOGY

Clinical course of repeated supratherapeutic ingestion of acetaminophen

(2011) Mohammed A. Alhelail et al.   CLINICAL TOXICOLOGY

Activation of autophagy protects against acetaminophen-induced hepatotoxicity

(2011) Hong-Min Ni et al.   HEPATOLOGY

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity

(2010) Chieko Saito et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY