Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer’s disease
出版年份 2023 全文链接
标题
Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer’s disease
作者
关键词
-
出版物
Translational Psychiatry
Volume 13, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2023-10-27
DOI
10.1038/s41398-023-02630-z
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer’s disease
- (2023) Lauren H. Fairley et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases
- (2023) Erik Nutma et al. Nature Communications
- Microglia Polarization From M1 to M2 in Neurodegenerative Diseases
- (2022) Shenrui Guo et al. Frontiers in Aging Neuroscience
- Translocator protein (18kDa) TSPO: a new diagnostic or therapeutic target for stress-related disorders?
- (2022) Rainer Rupprecht et al. MOLECULAR PSYCHIATRY
- Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO)
- (2022) Yuan Shi et al. NATURE NEUROSCIENCE
- Comparative Assessment of TSPO Modulators on Electroencephalogram Activity and Exploratory Behavior
- (2022) Rochelle M. Hines et al. Frontiers in Pharmacology
- The Role of Astrocytes in Synapse Loss in Alzheimer's Disease: A Systematic Review
- (2022) Lianne A. Hulshof et al. Frontiers in Cellular Neuroscience
- Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models
- (2022) Sarah M. Carpanini et al. Acta Neuropathologica Communications
- Targeting TSPO Reduces Inflammation and Apoptosis in an In Vitro Photoreceptor-Like Model of Retinal Degeneration
- (2022) Francesca Corsi et al. ACS Chemical Neuroscience
- Cellular sources of TSPO expression in healthy and diseased brain
- (2021) Erik Nutma et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- C1q, a small molecule with high impact on brain development: putative role for aging processes and the occurrence of Alzheimer’s disease
- (2021) Christian Rupprecht et al. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
- Neuroprotective effect of mitochondrial translocator protein ligand in a mouse model of tauopathy
- (2021) Lauren H. Fairley et al. Journal of Neuroinflammation
- Activated microglia do not increase 18 kDa translocator protein ( TSPO ) expression in the multiple sclerosis brain
- (2021) Erik Nutma et al. GLIA
- Complement System in Alzheimer’s Disease
- (2021) Akash Shah et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- TSPO deficiency accelerates amyloid pathology and neuroinflammation by impairing microglial phagocytosis
- (2021) Han Zhang et al. NEUROBIOLOGY OF AGING
- Microglia Polarization in Alzheimer’s Disease: Mechanisms and a Potential Therapeutic Target
- (2021) Qinqin Wang et al. Frontiers in Aging Neuroscience
- Complement-Mediated Events in Alzheimer’s Disease: Mechanisms and Potential Therapeutic Targets
- (2020) Andrea J. Tenner JOURNAL OF IMMUNOLOGY
- Neuronal activity increases translocator protein (TSPO) levels
- (2020) Tina Notter et al. MOLECULAR PSYCHIATRY
- Diagnostic and Therapeutic Potential of TSPO Studies Regarding Neurodegenerative Diseases, Psychiatric Disorders, Alcohol Use Disorders, Traumatic Brain Injury, and Stroke: An Update
- (2020) Jasmina Dimitrova-Shumkovska et al. Cells
- Association of epileptiform abnormalities and seizures in Alzheimer disease
- (2020) Alice D. Lam et al. NEUROLOGY
- GABAergic Inhibitory Interneuron Deficits in Alzheimer’s Disease: Implications for Treatment
- (2020) Yilan Xu et al. Frontiers in Neuroscience
- Regulation of Anxiety and Depression by Mitochondrial Translocator Protein-Mediated Steroidogenesis: the Role of Neurons
- (2020) Anna M. Barron et al. MOLECULAR NEUROBIOLOGY
- The Role of NMDA Receptors in Alzheimer’s Disease
- (2019) Jinping Liu et al. Frontiers in Neuroscience
- Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration
- (2019) Christopher M. Henstridge et al. Frontiers in Cellular Neuroscience
- TSPO Ligands Boost Mitochondrial Function and Pregnenolone Synthesis
- (2019) Imane Lejri et al. JOURNAL OF ALZHEIMERS DISEASE
- Disruption of gamma–delta relationship related to working memory deficits in first-episode psychosis
- (2019) Pascal Missonnier et al. JOURNAL OF NEURAL TRANSMISSION
- Increase in circulating cells coexpressing M1 and M2 macrophage surface markers in patients with systemic sclerosis
- (2018) Stefano Soldano et al. ANNALS OF THE RHEUMATIC DISEASES
- TSPO ligand PK11195 improves Alzheimer-related outcomes in aged female 3xTg-AD mice
- (2018) Amy Christensen et al. NEUROSCIENCE LETTERS
- Recent Advances by In Silico and In Vitro Studies of Amyloid-β 1-42 Fibril Depicted a S-Shape Conformation
- (2018) Daniel Miguel Ángel Villalobos Acosta et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The NMDA receptor antagonist Radiprodil reverses the synaptotoxic effects of different amyloid-beta (Aβ) species on long-term potentiation (LTP)
- (2018) Gerhard Rammes et al. NEUROPHARMACOLOGY
- Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors
- (2018) Jan M. Schulz et al. Nature Communications
- Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer’s disease Neurons
- (2017) Ravi Rajmohan et al. JOURNAL OF ALZHEIMERS DISEASE
- Microglia in Alzheimer’s disease
- (2017) David V. Hansen et al. JOURNAL OF CELL BIOLOGY
- A Role of Endogenous Progesterone in Stroke Cerebroprotection Revealed by the Neural-Specific Deletion of Its Intracellular Receptors
- (2017) Xiaoyan Zhu et al. JOURNAL OF NEUROSCIENCE
- Long Residence Time at the Neurosteroidogenic 18 kDa Translocator Protein Characterizes the Anxiolytic Ligand XBD173
- (2016) Barbara Costa et al. ACS Chemical Neuroscience
- Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology
- (2016) Elodie Martin et al. AGING CELL
- Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease
- (2016) Willem Kamphuis et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- TSPO ligand PK11195 alleviates neuroinflammation and beta-amyloid generation induced by systemic LPS administration
- (2016) Li Ma et al. BRAIN RESEARCH BULLETIN
- Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic Cells by Astrocytes
- (2016) Tal Iram et al. JOURNAL OF NEUROSCIENCE
- Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance
- (2016) Ming Lei et al. NEUROBIOLOGY OF DISEASE
- Complement and microglia mediate early synapse loss in Alzheimer mouse models
- (2016) S. Hong et al. SCIENCE
- Translocator protein-mediated pharmacology of cholesterol transport and steroidogenesis
- (2015) Vassilios Papadopoulos et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Amyloid-β(1-42) protofibrils stimulate a quantum of secreted IL-1β despite significant intracellular IL-1β accumulation in microglia
- (2014) Shana E. Terrill-Usery et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Peripheral Benzodiazepine Receptor/Translocator Protein Global Knock-out Mice Are Viable with No Effects on Steroid Hormone Biosynthesis
- (2014) Lan N. Tu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ligand for Translocator Protein Reverses Pathology in a Mouse Model of Alzheimer's Disease
- (2013) A. M. Barron et al. JOURNAL OF NEUROSCIENCE
- β-Amyloid oligomers in aging and Alzheimer’s disease
- (2013) Kathleen R. Zahs et al. Frontiers in Aging Neuroscience
- Fiji: an open-source platform for biological-image analysis
- (2012) Johannes Schindelin et al. NATURE METHODS
- Extrasynaptic GABAA Receptors: Their Function in the CNS and Implications for Disease
- (2012) Stephen G. Brickley et al. NEURON
- Hippocampus-dependent place learning enables spatial flexibility in C57BL6/N mice
- (2012) Karl R. Kleinknecht et al. Frontiers in Behavioral Neuroscience
- Soluble A Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors
- (2011) S. Li et al. JOURNAL OF NEUROSCIENCE
- Different Residues in the GABAA Receptor Benzodiazepine Binding Pocket Mediate Benzodiazepine Efficacy and Binding
- (2011) E. V. Morlock et al. MOLECULAR PHARMACOLOGY
- Neurosteroids and GABA-A Receptor Function
- (2011) Mingde Wang Frontiers in Endocrinology
- Regulation of translocator protein 18kDa (TSPO) expression in health and disease states☆
- (2010) Amani Batarseh et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
- (2010) Jorge J Palop et al. NATURE NEUROSCIENCE
- Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders
- (2010) Rainer Rupprecht et al. NATURE REVIEWS DRUG DISCOVERY
- GABAA,slow: causes and consequences
- (2010) Marco Capogna et al. TRENDS IN NEUROSCIENCES
- Interprotofilament interactions between Alzheimer's A 1-42 peptides in amyloid fibrils revealed by cryoEM
- (2009) R. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Translocator Protein (18 kD) as Target for Anxiolytics Without Benzodiazepine-Like Side Effects
- (2009) Rainer Rupprecht et al. SCIENCE
- Interleukin-1β impairs brain derived neurotrophic factor-induced signal transduction
- (2007) Liqi Tong et al. NEUROBIOLOGY OF AGING
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