标题
The Role of Astrocytes in Synapse Loss in Alzheimer's Disease: A Systematic Review
作者
关键词
-
出版物
Frontiers in Cellular Neuroscience
Volume 16, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2022-06-16
DOI
10.3389/fncel.2022.899251
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Reactive astrocytes as treatment targets in Alzheimer's disease—Systematic review of studies using the APPswePS1dE9 mouse model
- (2021) Tamar Smit et al. GLIA
- Reactive astrocyte nomenclature, definitions, and future directions
- (2021) Carole Escartin et al. NATURE NEUROSCIENCE
- Physiological and Pathological Ageing of Astrocytes in the Human Brain
- (2021) Marloes Verkerke et al. NEUROCHEMICAL RESEARCH
- Pharmacological ablation of astrocytes reduces Aβ degradation and synaptic connectivity in an ex vivo model of Alzheimer’s disease
- (2021) Nicola Davis et al. Journal of Neuroinflammation
- Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia
- (2021) Chao Wang et al. NEURON
- The PRISMA 2020 statement: An updated guideline for reporting systematic reviews
- (2021) Matthew J. Page et al. PLOS MEDICINE
- Knockdown of astrocytic Grin2a aggravates β‐amyloid‐induced memory and cognitive deficits through regulating nerve growth factor
- (2021) Zunshu Du et al. AGING CELL
- FoxO3 deficiency in cortical astrocytes leads to impaired lipid metabolism and aggravated amyloid pathology
- (2021) Shuqi Du et al. AGING CELL
- Astrocyte-neuron interplay is critical for Alzheimer's disease pathogenesis and is rescued by TRPA1 channel blockade
- (2021) Adrien Paumier et al. BRAIN
- A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease
- (2021) Douglas P. Wightman et al. NATURE GENETICS
- Disruption of the astrocyte–neuron interaction is responsible for the impairments in learning and memory in 5XFAD mice: an Alzheimer’s disease animal model
- (2021) Moonseok Choi et al. Molecular Brain
- Amyloid Fibril–Induced Astrocytic Glutamate Transporter Disruption Contributes to Complement C1q-Mediated Microglial Pruning of Glutamatergic Synapses
- (2020) Jiang Wu et al. MOLECULAR NEUROBIOLOGY
- Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study
- (2020) Eric M. Reiman et al. Nature Communications
- APOE Alleles and Diet in Brain Aging and Alzheimer’s Disease
- (2020) Hussein N. Yassine et al. Frontiers in Aging Neuroscience
- Amyloid‐β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease
- (2020) Maria V. Sanchez‐Mico et al. GLIA
- Astrocyte-derived clusterin suppresses amyloid formation in vivo
- (2020) Aleksandra M. Wojtas et al. Molecular Neurodegeneration
- Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis
- (2020) Joon-Hyuk Lee et al. NATURE
- Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis
- (2020) Yun Chen et al. NEURON
- Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
- (2019) Iris E. Jansen et al. NATURE GENETICS
- Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release
- (2019) Shaimaa Mahmoud et al. Cells
- Conditional BDNF delivery from astrocytes rescues memory deficits, spine density and synaptic properties in the 5xFAD mouse model of Alzheimer disease
- (2019) Benoit de Pins et al. JOURNAL OF NEUROSCIENCE
- Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets
- (2019) Sohaib Nizami et al. BRITISH JOURNAL OF PHARMACOLOGY
- Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk
- (2019) Yu-Wen Alvin Huang et al. JOURNAL OF NEUROSCIENCE
- Phagocytosis in the Brain: Homeostasis and Disease
- (2019) Dylan A. Galloway et al. Frontiers in Immunology
- Modeling Alzheimer’s disease with iPSC-derived brain cells
- (2019) Jay Penney et al. MOLECULAR PSYCHIATRY
- A vicious cycle of β amyloid–dependent neuronal hyperactivation
- (2019) Benedikt Zott et al. SCIENCE
- Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy
- (2019) Tiffany Wu et al. Cell Reports
- The complement cascade in Alzheimer’s disease: a systematic review and meta-analysis
- (2019) Saffire H. Krance et al. MOLECULAR PSYCHIATRY
- Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease
- (2019) Darrick T. Balu et al. NEUROBIOLOGY OF DISEASE
- Modeling Alzheimer’s disease with human iPS cells: advancements, lessons, and applications
- (2019) Sofia Essayan-Perez et al. NEUROBIOLOGY OF DISEASE
- Astrocytes in primary cultures express serine racemase, synthesize d -serine and acquire A1 reactive astrocyte features
- (2018) Suyan Li et al. BIOCHEMICAL PHARMACOLOGY
- P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer’s disease model
- (2018) Nicole Reichenbach et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Specific deletion connexin43 in astrocyte ameliorates cognitive dysfunction in APP/PS1 mice
- (2018) Ren Runan et al. LIFE SCIENCES
- APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types
- (2018) Yuan-Ta Lin et al. NEURON
- Cell adhesion and matricellular support by astrocytes of the tripartite synapse
- (2018) Anne E.J. Hillen et al. PROGRESS IN NEUROBIOLOGY
- Functional Roles of Astrocyte Calcium Elevations: From Synapses to Behavior
- (2018) Sónia Guerra-Gomes et al. Frontiers in Cellular Neuroscience
- Activated forms of astrocytes with higher GLT-1 expression are associated with cognitive normal subjects with Alzheimer pathology in human brain
- (2018) Eiji Kobayashi et al. Scientific Reports
- The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain
- (2018) Matthew M. Boisvert et al. Cell Reports
- Astrocytic Adenosine A2A Receptors Control the Amyloid-β Peptide-Induced Decrease of Glutamate Uptake
- (2018) Marco Matos et al. JOURNAL OF ALZHEIMERS DISEASE
- Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer’s Disease
- (2018) Celia Luchena et al. MEDIATORS OF INFLAMMATION
- Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease
- (2018) Kelly Ceyzériat et al. Acta Neuropathologica Communications
- CIP2A-promoted astrogliosis induces AD-like synaptic degeneration and cognitive deficits
- (2018) Yang-Ping Shentu et al. NEUROBIOLOGY OF AGING
- Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease
- (2017) Angela Gomez-Arboledas et al. GLIA
- APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes
- (2017) Jing Zhao et al. HUMAN MOLECULAR GENETICS
- Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model
- (2017) Luan Pereira Diniz et al. JOURNAL OF NEUROSCIENCE
- ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
- (2017) Yang Shi et al. NATURE
- Neurotoxic reactive astrocytes are induced by activated microglia
- (2017) Shane A. Liddelow et al. NATURE
- Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders
- (2017) Urte Neniskyte et al. NATURE REVIEWS NEUROSCIENCE
- Cell Biology of Astrocyte-Synapse Interactions
- (2017) Nicola J. Allen et al. NEURON
- Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice
- (2017) Qiaoqiao Shi et al. Science Translational Medicine
- ApoE Influences the Blood-Brain Barrier Through the NF-κB/MMP-9 Pathway After Traumatic Brain Injury
- (2017) Zhipeng Teng et al. Scientific Reports
- FK506 Reduces Amyloid Plaque Burden and Induces MMP-9 in AβPP/PS1 Double Transgenic Mice
- (2017) Hyun-Seok Hong et al. JOURNAL OF ALZHEIMERS DISEASE
- Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability
- (2016) Martijn C. de Wilde et al. Alzheimers & Dementia
- The amyloid hypothesis of Alzheimer's disease at 25 years
- (2016) Dennis J Selkoe et al. EMBO Molecular Medicine
- Neutrophil Gelatinase-Associated Lipocalin and its Receptors in Alzheimer’s Disease (AD) Brain Regions: Differential Findings in AD with and without Depression
- (2016) Doortje W. Dekens et al. JOURNAL OF ALZHEIMERS DISEASE
- Astrocytic GluN2A and GluN2B Oppose the Synaptotoxic Effects of Amyloid-β1-40 in Hippocampal Cells
- (2016) Yan Li et al. JOURNAL OF ALZHEIMERS DISEASE
- Role of transient receptor potential ankyrin 1 channels in Alzheimer’s disease
- (2016) Kuan-I Lee et al. Journal of Neuroinflammation
- Astrocyte calcium signaling: the third wave
- (2016) Narges Bazargani et al. NATURE NEUROSCIENCE
- Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse
- (2016) Ye Zhang et al. NEURON
- Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes
- (2016) Won-Suk Chung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease
- (2016) Lana M. Osborn et al. PROGRESS IN NEUROBIOLOGY
- Complement and microglia mediate early synapse loss in Alzheimer mouse models
- (2016) S. Hong et al. SCIENCE
- Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging
- (2016) J. K. Hefendehl et al. Nature Communications
- Mechanisms of Aβ Clearance and Degradation by Glial Cells
- (2016) Miriam Ries et al. Frontiers in Aging Neuroscience
- Regulation of astrocyte pathology by fluoxetine prevents the deterioration of Alzheimer phenotypes in an APP/PS1 mouse model
- (2015) Jinping Qiao et al. GLIA
- GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease
- (2015) Willem Kamphuis et al. GLIA
- Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease
- (2015) Kou Takahashi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory
- (2015) Anna G Orr et al. NATURE NEUROSCIENCE
- Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease
- (2015) Joannee Zumkehr et al. NEUROBIOLOGY OF AGING
- Thrombospondin-1 prevents amyloid beta–mediated synaptic pathology in Alzheimer's disease
- (2015) Sung Min Son et al. NEUROBIOLOGY OF AGING
- Lipocalin 2 modulates the cellular response to amyloid beta
- (2014) S D Mesquita et al. CELL DEATH AND DIFFERENTIATION
- Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction
- (2014) Marie Orre et al. NEUROBIOLOGY OF AGING
- Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits
- (2014) Milos Pekny et al. PHYSIOLOGICAL REVIEWS
- Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model
- (2014) Andrea Delekate et al. Nature Communications
- ApoE4 Delays Dendritic Spine Formation during Neuron Development and Accelerates Loss of Mature Spines in Vitro
- (2013) Evelyn Nwabuisi-Heath et al. ASN Neuro
- Astrocytes and Glutamate Homoeostasis in Alzheimer's Disease: A Decrease in Glutamine Synthetase, But Not in Glutamate Transporter-1, in the Prefrontal Cortex
- (2013) Magdalena Kulijewicz-Nawrot et al. ASN Neuro
- Dissecting phenotypic traits linked to human resilience to Alzheimer’s pathology
- (2013) Beatriz G. Perez-Nievas et al. BRAIN
- Amyloid-β Inhibits Thrombospondin 1 Release From Cultured Astrocytes: Effects on Synaptic Protein Expression
- (2013) Kakulavarapu V. Rama Rao et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Antagonistic Interaction between Adenosine A2A Receptors and Na+/K+-ATPase- 2 Controlling Glutamate Uptake in Astrocytes
- (2013) M. Matos et al. JOURNAL OF NEUROSCIENCE
- Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways
- (2013) Won-Suk Chung et al. NATURE
- Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
- (2013) Jean-Charles Lambert et al. NATURE GENETICS
- Cellular Source-Specific Effects of Apolipoprotein (Apo) E4 on Dendrite Arborization and Dendritic Spine Development
- (2013) Sachi Jain et al. PLoS One
- A induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
- (2013) M. Talantova et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice
- (2012) Andrew W. Kraft et al. FASEB JOURNAL
- The “quad-partite” synapse: Microglia-synapse interactions in the developing and mature CNS
- (2012) Dorothy P. Schafer et al. GLIA
- Early Stage Drug Treatment That Normalizes Proinflammatory Cytokine Production Attenuates Synaptic Dysfunction in a Mouse Model That Exhibits Age-Dependent Progression of Alzheimer's Disease-Related Pathology
- (2012) A. D. Bachstetter et al. JOURNAL OF NEUROSCIENCE
- Astrocyte-Originated ATP Protects A 1-42-Induced Impairment of Synaptic Plasticity
- (2012) E. S. Jung et al. JOURNAL OF NEUROSCIENCE
- Alzheimer's Disease-Linked Mutations in Presenilin-1 Result in a Drastic Loss of Activity in Purified γ-Secretase Complexes
- (2012) Matthias Cacquevel et al. PLoS One
- The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis
- (2011) Jie Zhao et al. Journal of Neuroinflammation
- PKC Activation Prevents Synaptic Loss, A Elevation, and Cognitive Deficits in Alzheimer's Disease Transgenic Mice
- (2011) J. Hongpaisan et al. JOURNAL OF NEUROSCIENCE
- The selective and competitive N-methyl-D-aspartate receptor antagonist, (−)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid, prevents synaptic toxicity induced by amyloid-β in mice
- (2011) M.A. Bicca et al. NEUROSCIENCE
- Long-term potentiation depends on release of d-serine from astrocytes
- (2010) Christian Henneberger et al. NATURE
- Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease
- (2010) Heather A. Scott et al. NEUROBIOLOGY OF AGING
- Uniquely Hominid Features of Adult Human Astrocytes
- (2009) N. A. Oberheim et al. JOURNAL OF NEUROSCIENCE
- Tripartite synapses: astrocytes process and control synaptic information
- (2009) Gertrudis Perea et al. TRENDS IN NEUROSCIENCES
- Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice
- (2008) R. Minkeviciene et al. JOURNAL OF NEUROCHEMISTRY
- Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades
- (2008) M. Matos et al. NEUROSCIENCE
- Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease
- (2008) M. A. Busche et al. SCIENCE
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