Complement System in Alzheimer’s Disease

Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex

(2021) Peng Wang et al.   Nature Communications

Aducanumab produced a clinically meaningful benefit in association with amyloid lowering

(2021) Jeffrey Cummings et al.   Alzheimers Research & Therapy

Multiple plasma metals, genetic risk and serum complement C3, C4: A gene-metal interaction study

(2021) Jing Jiang et al.   CHEMOSPHERE

Synaptic mitochondrial dysfunction and septin accumulation are linked to complement-mediated synapse loss in an Alzheimer’s disease animal model

(2020) Balázs A. Györffy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Complement-Mediated Events in Alzheimer’s Disease: Mechanisms and Potential Therapeutic Targets

(2020) Andrea J. Tenner   JOURNAL OF IMMUNOLOGY

Development of the clinical candidate PBD-C06, a humanized pGlu3-Aβ-specific antibody against Alzheimer’s disease with reduced complement activation

(2020) Thore Hettmann et al.   Scientific Reports

Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain

(2020) William M. Pardridge   Frontiers in Aging Neuroscience

Complement: Bridging the innate and adaptive immune systems in sterile inflammation

(2020) Martin W. Lo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Immunomodulatory role of mesenchymal stem cells in Alzheimer's disease

(2020) Lu Zhang et al.   LIFE SCIENCES

Assessment of the Role of C3(H2O) in the Alternative Pathway

(2020) Karin Fromell et al.   Frontiers in Immunology

Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

(2020) Gill Livingston et al.   LANCET

Impacts of AD-Related ABCA7 and CLU Variants on Default Mode Network Connectivity in Healthy Middle-Age Adults

(2020) Xin Yuan Zhang et al.   Frontiers in Molecular Neuroscience

The good, the bad, and the opportunities of the complement system in neurodegenerative disease

(2020) Nicole D. Schartz et al.   Journal of Neuroinflammation

Activation of mGluR1 Mediates C1q-Dependent Microglial Phagocytosis of Glutamatergic Synapses in Alzheimer’s Rodent Models

(2019) Bihua Bie et al.   MOLECULAR NEUROBIOLOGY

Adalimumab improves cognitive impairment, exerts neuroprotective effects and attenuates neuroinflammation in an Aβ1-40-injected mouse model of Alzheimer's disease

(2019) JIAE Park et al.   CYTOTHERAPY

The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

(2019) Carlo Sala Frigerio et al.   Cell Reports

Astroglial endfeet exhibit distinct Ca 2+ signals during hypoosmotic conditions

(2019) Martine Eilert‐Olsen et al.   GLIA

Activated microglia desialylate their surface, stimulating complement receptor 3‐mediated phagocytosis of neurons

(2019) David H. Allendorf et al.   GLIA

Heterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice

(2019) Suzanne E. Hickman et al.   Frontiers in Immunology

Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer’s Disease

(2018) D. Allan Butterfield et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of Amyloid Precursor Protein (APP) and Its Derivatives in the Biology and Cell Fate Specification of Neural Stem Cells

(2018) Raquel Coronel et al.   MOLECULAR NEUROBIOLOGY

Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease

(2018) Lawrence S. Honig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning

(2018) Balázs A. Györffy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement: The Emerging Architect of the Developing Brain

(2018) Liam G. Coulthard et al.   TRENDS IN NEUROSCIENCES

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Postsynaptic Proteome of Non-Demented Individuals with Alzheimer’s Disease Neuropathology

(2018) Olga Zolochevska et al.   JOURNAL OF ALZHEIMERS DISEASE

Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer’s disease

(2018) Iris J. Broce et al.   ACTA NEUROPATHOLOGICA

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

(2018) Borislav Dejanovic et al.   NEURON

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

(2018) Alexandra Litvinchuk et al.   NEURON

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

(2017) Gordon K. Wilcock et al.   JOURNAL OF ALZHEIMERS DISEASE

Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain

(2017) Maria I. Fonseca et al.   Journal of Neuroinflammation

Dementia prevention, intervention, and care

(2017) Gill Livingston et al.   LANCET

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Structure and activation of C1, the complex initiating the classical pathway of the complement cascade

(2017) Simon A. Mortensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

(2017) Qiaoqiao Shi et al.   Science Translational Medicine

The complement system is dysfunctional in metabolic disease: Evidences in plasma and adipose tissue from obese and insulin resistant subjects

(2017) José María Moreno-Navarrete et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation

(2017) Ruodan Nan et al.   STRUCTURE

On the path to 2025: understanding the Alzheimer’s disease continuum

(2017) Paul S. Aisen et al.   Alzheimers Research & Therapy

A phase III randomized trial of gantenerumab in prodromal Alzheimer’s disease

(2017) Susanne Ostrowitzki et al.   Alzheimers Research & Therapy

C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions

(2017) Jinhua Lu et al.   Frontiers in Immunology

Central Nervous System LipoproteinsHighlights

(2016) Robert W. Mahley   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Innate Immunity Stimulation via Toll-Like Receptor 9 Ameliorates Vascular Amyloid Pathology in Tg-SwDI Mice with Associated Cognitive Benefits

(2016) Henrieta Scholtzova et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Gender and incidence of dementia in the Framingham Heart Study from mid-adult life

(2015) Geneviève Chêne et al.   Alzheimers & Dementia

Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline

(2015) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

(2015) Hong Lian et al.   NEURON

Metallothionein-3 modulates the amyloid β endocytosis of astrocytes through its effects on actin polymerization

(2015) Sook-Jeong Lee et al.   Molecular Brain

Microglia Development and Function

(2014) Debasis Nayak et al.   Annual Review of Immunology

Capturing a Reactive State of Amyloid Aggregates

(2014) Sudhakar Parthasarathy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibrillar Amyloid-  Peptides Activate Microglia via TLR2: Implications for Alzheimer's Disease

(2014) M. Jana et al.   JOURNAL OF IMMUNOLOGY

Remodeling of dendrites and spines in theC1qknockout model of genetic epilepsy

(2013) Yunyong Ma et al.   EPILEPSIA

Innate Immunity and Neuroinflammation

(2013) Abhishek Shastri et al.   MEDIATORS OF INFLAMMATION

Oligomers of beta-amyloid protein (Aβ1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-B mechanism in the rat brain

(2012) I. Carrero et al.   EXPERIMENTAL NEUROLOGY

Reduced removal of synaptic terminals from axotomized spinal motoneurons in the absence of complement C3

(2012) Alexander Berg et al.   EXPERIMENTAL NEUROLOGY

Generation of Alzheimer Disease-associated Amyloid β42/43Peptide by γ-Secretase Can Be Inhibited Directly by Modulation of Membrane Thickness

(2012) Edith Winkler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Review: Activation patterns of microglia and their identification in the human brain

(2012) D. Boche et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2

(2012) D. Heja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of microglia effector functions by tumor necrosis factor signaling

(2011) Ashley S. Harms et al.   GLIA

TLR2 Is a Primary Receptor for Alzheimer's Amyloid   Peptide To Trigger Neuroinflammatory Activation

(2011) S. Liu et al.   JOURNAL OF IMMUNOLOGY

Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease

(2011) Maria I Fonseca et al.   Journal of Neuroinflammation

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Enhanced synaptic connectivity and epilepsy in C1q knockout mice

(2010) Yunxiang Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation

(2009) Vengadesan Krishnan et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Properdin: Emerging Roles of a Pattern-Recognition Molecule

(2009) Claudia Kemper et al.   Annual Review of Immunology

Complement and its role in innate and adaptive immune responses

(2009) Jason R Dunkelberger et al.   CELL RESEARCH

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Structure of complement fragment C3b–factor H and implications for host protection by complement regulators

(2009) Jin Wu et al.   NATURE IMMUNOLOGY

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic

(2008) S. Jimenez et al.   JOURNAL OF NEUROSCIENCE

Role of complement anaphylatoxin receptors (C3aR, C5aR) in the development of the rat cerebellum

(2008) Magalie Bénard et al.   MOLECULAR IMMUNOLOGY