Integrative multi-omic profiling of adult mouse brain endothelial cells and potential implications in Alzheimer’s disease

Targeting insulin‐like growth factor‐1 receptor (IGF1R) for brain delivery of biologics

(2022) Wael Alata et al.   FASEB JOURNAL

A single-cell atlas of the normal and malformed human brain vasculature

(2022) Ethan A. Winkler et al.   SCIENCE

Activation of Wnt/β-catenin pathway mitigates blood–brain barrier dysfunction in Alzheimer’s disease

(2022) Qi Wang et al.   BRAIN

Blood–Brain Barrier Breakdown: An Emerging Biomarker of Cognitive Impairment in Normal Aging and Dementia

(2021) Basharat Hussain et al.   Frontiers in Neuroscience

Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype

(2021) Stefano Tarantini et al.   GeroScience

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

(2020) Joanna Kalucka et al.   CELL

Caveolae in CNS arterioles mediate neurovascular coupling

(2020) Brian W. Chow et al.   NATURE

A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture

(2020) Mark F Sabbagh et al.   eLife

Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

(2020) Ankit Jambusaria et al.   eLife

The blood–brain barrier in health and disease: Important unanswered questions

(2020) Caterina P. Profaci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

(2020) Axel Montagne et al.   NATURE

Efficient isolation of brain capillary from a single frozen mouse brain for protein expression analysis

(2020) Seiryo Ogata et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuronal regulation of the blood–brain barrier and neurovascular coupling

(2020) Luke Kaplan et al.   NATURE REVIEWS NEUROSCIENCE

IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer’s Disease Transgenic Mouse Model

(2020) Mona Sohrabi et al.   Frontiers in Cellular Neuroscience

Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss

(2020) Maarja Andaloussi Mäe et al.   CIRCULATION RESEARCH

Identification of Blood–Brain Barrier-Associated Proteins in the Human Brain

(2020) Marina Zajec et al.   JOURNAL OF PROTEOME RESEARCH

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures

(2019) Yanshu Wang et al.   eLife

Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice

(2019) Fabienne Benz et al.   eLife

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

The blood-brain barrier: Physiology and strategies for drug delivery

(2019) Rucha Pandit et al.   ADVANCED DRUG DELIVERY REVIEWS

Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module

(2019) Roeben Nocon Munji et al.   NATURE NEUROSCIENCE

Functional morphology of the blood–brain barrier in health and disease

(2018) Stefan Liebner et al.   ACTA NEUROPATHOLOGICA

Identification and Quantification of Blood-Brain Barrier Transporters in Isolated Rat Brain Microvessels

(2018) Hajar Al Feteisi et al.   JOURNAL OF NEUROCHEMISTRY

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

The role of brain vasculature in neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   NATURE NEUROSCIENCE

Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells

(2018) Mark F Sabbagh et al.   eLife

Fine Tuning of Sox17 and Canonical Wnt Coordinates the Permeability Properties of the Blood-Brain Barrier

(2018) Monica Corada et al.   CIRCULATION RESEARCH

Gpr124 is essential for blood–brain barrier integrity in central nervous system disease

(2017) Junlei Chang et al.   NATURE MEDICINE

Sorbin and SH3 domain-containing protein 2 (SORBS2) is a component of the acto-myosin ring at the apical junctional complex in epithelial cells

(2017) Karin Fredriksson-Lidman et al.   PLoS One

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies

(2016) Y. Joy Yu Zuchero et al.   NEURON

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

The Endothelial Transcription Factor ERG Promotes Vascular Stability and Growth through Wnt/β-Catenin Signaling

(2015) Graeme M. Birdsey et al.   DEVELOPMENTAL CELL

LSR/angulin-1 is a tricellular tight junction protein involved in blood–brain barrier formation

(2015) Fabien Sohet et al.   JOURNAL OF CELL BIOLOGY

Rapid mass spectrometric conversion of tissue biopsy samples into permanent quantitative digital proteome maps

(2015) Tiannan Guo et al.   NATURE MEDICINE

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Canonical WNT signaling components in vascular development and barrier formation

(2014) Yulian Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

ERG Is a Critical Regulator of Wnt/LEF1 Signaling in Prostate Cancer

(2013) L. Wu et al.   CANCER RESEARCH

Cingulin, paracingulin, and PLEKHA7: signaling and cytoskeletal adaptors at the apical junctional complex

(2012) Sandra Citi et al.   Annals of the New York Academy of Sciences

Death Receptors DR6 and TROY Regulate Brain Vascular Development

(2012) Stephen J. Tam et al.   DEVELOPMENTAL CELL

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

TSC-22 Promotes Transforming Growth Factor  -Mediated Cardiac Myofibroblast Differentiation by Antagonizing Smad7 Activity

(2011) X. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells

(2010) Richard Daneman et al.   PLoS One

Essential Regulation of CNS Angiogenesis by the Orphan G Protein-Coupled Receptor GPR124

(2010) F. Kuhnert et al.   SCIENCE

Norrin, Frizzled-4, and Lrp5 Signaling in Endothelial Cells Controls a Genetic Program for Retinal Vascularization

(2009) Xin Ye et al.   CELL

Endothelial cell heterogeneity of blood-brain barrier gene expression along the cerebral microvasculature

(2009) Jennifer A. Macdonald et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Wnt/ -catenin signaling is required for CNS, but not non-CNS, angiogenesis

(2009) R. Daneman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt/β-catenin signaling controls development of the blood–brain barrier

(2008) Stefan Liebner et al.   JOURNAL OF CELL BIOLOGY

Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature

(2008) J. M. Stenman et al.   SCIENCE