Functional morphology of the blood–brain barrier in health and disease

The contribution of neutrophils to CNS autoimmunity

(2018) Emily R. Pierson et al.   CLINICAL IMMUNOLOGY

Multiple Sclerosis

(2018) Hernan Nicolas Lemus et al.   NEUROLOGIC CLINICS

Dynamic Analysis of the Blood-Brain Barrier Disruption in Experimental Stroke Using Time Domain in Vivo Fluorescence Imaging

(2018) Abedelnasser Abulrob et al.   Molecular Imaging

Personalized translational epilepsy research — Novel approaches and future perspectives

(2017) Sebastian Bauer et al.   EPILEPSY & BEHAVIOR

IFN-γ promotes transendothelial migration of CD4+ T cells across the blood-brain barrier

(2017) Sandip Ashok Sonar et al.   IMMUNOLOGY AND CELL BIOLOGY

Diffuse microvascular dysfunction and loss of white matter integrity predict poor outcomes in patients with acute ischemic stroke

(2017) Natalia S Rost et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

(2017) Axel Montagne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Therapeutic targeting of the angiopoietin–TIE pathway

(2017) Pipsa Saharinen et al.   NATURE REVIEWS DRUG DISCOVERY

Brain barriers in health and disease

(2017) Richard Daneman et al.   NEUROBIOLOGY OF DISEASE

The blood-brain barrier in Alzheimer's disease

(2017) Elena Zenaro et al.   NEUROBIOLOGY OF DISEASE

Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation

(2017) Chris Cho et al.   NEURON

Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation

(2017) Brian Wai Chow et al.   NEURON

Dual role of ALCAM in neuroinflammation and blood–brain barrier homeostasis

(2017) Marc-André Lécuyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD146 coordinates brain endothelial cell–pericyte communication for blood–brain barrier development

(2017) Jianan Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

(2017) Martina Schmittnaegel et al.   Science Translational Medicine

Combined antiangiogenic and anti–PD-L1 therapy stimulates tumor immunity through HEV formation

(2017) Elizabeth Allen et al.   Science Translational Medicine

Multiparametric Magnetic Resonance Imaging for Prediction of Parenchymal Hemorrhage in Acute Ischemic Stroke After Reperfusion Therapy

(2017) Kambiz Nael et al.   STROKE

Caveolin1 Is Required for Th1 Cell Infiltration, but Not Tight Junction Remodeling, at the Blood-Brain Barrier in Autoimmune Neuroinflammation

(2017) Sarah E. Lutz et al.   Cell Reports

NETosis in Alzheimer’s Disease

(2017) Enrica Caterina Pietronigro et al.   Frontiers in Immunology

Differentiation and Transmigration of CD4 T Cells in Neuroinflammation and Autoimmunity

(2017) Sandip Ashok Sonar et al.   Frontiers in Immunology

Evolution of blood-brain-barrier permeability after acute ischemic stroke

(2017) Zamir Merali et al.   PLoS One

Angiopoietin-2-induced blood–brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling

(2016) Stefanie Gurnik et al.   ACTA NEUROPATHOLOGICA

Corticosteroids compromise survival in glioblastoma

(2016) Kenneth L. Pitter et al.   BRAIN

T-cell brain infiltration and immature antigen-presenting cells in transgenic models of Alzheimer’s disease-like cerebral amyloidosis

(2016) M.T. Ferretti et al.   BRAIN BEHAVIOR AND IMMUNITY

The Multifaceted Role of Perivascular Macrophages in Tumors

(2016) Claire E. Lewis et al.   CANCER CELL

Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment

(2016) Jin-Sung Park et al.   CANCER CELL

Impact of Blood-Brain Barrier Integrity on Tumor Growth and Therapy Response in Brain Metastases

(2016) M. Osswald et al.   CLINICAL CANCER RESEARCH

Targeting Tie2 for Treatment of Diabetic Retinopathy and Diabetic Macular Edema

(2016) Peter A. Campochiaro et al.   Current Diabetes Reports

Glial-endothelial crosstalk regulates blood–brain barrier function

(2016) Lara Cheslow et al.   CURRENT OPINION IN PHARMACOLOGY

Prediction of hemorrhagic transformation after experimental ischemic stroke using MRI-based algorithms

(2016) Mark JRJ Bouts et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cutting Edge: CD99 Is a Novel Therapeutic Target for Control of T Cell–Mediated Central Nervous System Autoimmune Disease

(2016) Ryan C. Winger et al.   JOURNAL OF IMMUNOLOGY

Cytokine and chemokine alterations in tissue, CSF, and plasma in early presymptomatic phase of experimental allergic encephalomyelitis (EAE), in a rat model of multiple sclerosis

(2016) Nozha Borjini et al.   Journal of Neuroinflammation

Pericytes as Inducers of Rapid, Matrix Metalloproteinase-9-Dependent Capillary Damage during Ischemia

(2016) Robert G. Underly et al.   JOURNAL OF NEUROSCIENCE

Caveolin-1 Is Critical for Lymphocyte Trafficking into Central Nervous System during Experimental Autoimmune Encephalomyelitis

(2016) Hao Wu et al.   JOURNAL OF NEUROSCIENCE

Bevacizumab Prevents Brain Metastases Formation in Lung Adenocarcinoma

(2016) A. Ilhan-Mutlu et al.   MOLECULAR CANCER THERAPEUTICS

Pericytes of the neurovascular unit: key functions and signaling pathways

(2016) Melanie D Sweeney et al.   NATURE NEUROSCIENCE

Ten years of anti-vascular endothelial growth factor therapy

(2016) Napoleone Ferrara et al.   NATURE REVIEWS DRUG DISCOVERY

Decrease of VEGF-A in myeloid cells attenuates glioma progression and prolongs survival in an experimental glioma model

(2016) Nadja Osterberg et al.   NEURO-ONCOLOGY

Tracer kinetic modelling for DCE-MRI quantification of subtle blood–brain barrier permeability

(2016) Anna K. Heye et al.   NEUROIMAGE

DCE-MRI blood–brain barrier assessment in acute ischemic stroke

(2016) Kersten Villringer et al.   NEUROLOGY

Th9 cells in the pathogenesis of EAE and multiple sclerosis

(2016) Wassim Elyaman et al.   Seminars in Immunopathology

Identification of Reversible Disruption of the Human Blood–Brain Barrier Following Acute Ischemia

(2016) Alexis N. Simpkins et al.   STROKE

Imaging of Leukocyte Trafficking in Alzheimer’s Disease

(2016) Enrica Pietronigro et al.   Frontiers in Immunology

Microglia–blood vessel interactions: a double-edged sword in brain pathologies

(2015) Nevenka Dudvarski Stankovic et al.   ACTA NEUROPATHOLOGICA

Overcoming the blood–brain tumor barrier for effective glioblastoma treatment

(2015) O. van Tellingen et al.   DRUG RESISTANCE UPDATES

Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma

(2015) A. Scholz et al.   EMBO Molecular Medicine

Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier

(2015) Michael Abadier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

LSR/angulin-1 is a tricellular tight junction protein involved in blood–brain barrier formation

(2015) Fabien Sohet et al.   JOURNAL OF CELL BIOLOGY

Brain barriers: Crosstalk between complex tight junctions and adherens junctions

(2015) Silvia Tietz et al.   JOURNAL OF CELL BIOLOGY

A Novel SPECT-Based Approach Reveals Early Mechanisms of Central and Peripheral Inflammation after Cerebral Ischemia

(2015) Krisztián Szigeti et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

(2015) Matthew R Halliday et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain endothelial TAK1 and NEMO safeguard the neurovascular unit

(2015) Dirk A. Ridder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer’s disease–like mice

(2015) Stefan Prokop et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aβ1-42oligomer-induced leakage in anin vitroblood-brain barrier model is associated with up-regulation of RAGE and metalloproteinases, and down-regulation of tight junction scaffold proteins

(2015) Wenbin Wan et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin

(2015) Elena Zenaro et al.   NATURE MEDICINE

Clinical relevance of specific T-cell activation in the blood and cerebrospinal fluid of patients with mild Alzheimer's disease

(2015) Gero Lueg et al.   NEUROBIOLOGY OF AGING

Focal disturbances in the blood–brain barrier are associated with formation of neuroinflammatory lesions

(2015) Jorge Ivan Alvarez et al.   NEUROBIOLOGY OF DISEASE

Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis

(2015) Benoit Vanhollebeke et al.   eLife

T Lymphocyte–Endothelial Interactions: Emerging Understanding of Trafficking and Antigen-Specific Immunity

(2015) Christopher V. Carman et al.   Frontiers in Immunology

Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer’s disease lacking functional B and T cells

(2015) Claudia Späni et al.   Acta Neuropathologica Communications

Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy

(2015) Laura J Blair et al.   Acta Neuropathologica Communications

Novel insights into the development and maintenance of the blood–brain barrier

(2014) Britta Engelhardt et al.   CELL AND TISSUE RESEARCH

Gpr124 Controls CNS Angiogenesis and Blood-Brain Barrier Integrity by Promoting Ligand-Specific Canonical Wnt Signaling

(2014) Yulian Zhou et al.   DEVELOPMENTAL CELL

Monitoring Stroke Progression: In Vivo Imaging of Cortical Perfusion, Blood—Brain Barrier Permeability and Cellular Damage in the Rat Photothrombosis Model

(2014) Karl Schoknecht et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Canonical WNT signaling components in vascular development and barrier formation

(2014) Yulian Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Cytokine-Regulated Neutrophil Recruitment Is Required for Brain but Not Spinal Cord Inflammation during Experimental Autoimmune Encephalomyelitis

(2014) Sarah B. Simmons et al.   JOURNAL OF IMMUNOLOGY

Neutrophils Mediate Blood–Spinal Cord Barrier Disruption in Demyelinating Neuroinflammatory Diseases

(2014) Benoit Aubé et al.   JOURNAL OF IMMUNOLOGY

Rapid Remodeling of Tight Junctions during Paracellular Diapedesis in a Human Model of the Blood–Brain Barrier

(2014) Ryan C. Winger et al.   JOURNAL OF IMMUNOLOGY

Magnetic resonance imaging of post-ischemic blood–brain barrier damage with PEGylated iron oxide nanoparticles

(2014) Dong-Fang Liu et al.   Nanoscale

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

(2014) Daniel Knowland et al.   NEURON

Role of caveolin-1 in the biology of the blood-brain barrier

(2014) Yong-Lin Zhao et al.   REVIEWS IN THE NEUROSCIENCES

Disruption of astrocyte–vascular coupling and the blood–brain barrier by invading glioma cells

(2014) Stacey Watkins et al.   Nature Communications

Multimodal Nanoprobes Evaluating Physiological Pore Size of Brain Vasculatures in Ischemic Stroke Models

(2014) Shuyan Zheng et al.   Advanced Healthcare Materials

Deciphering and Reversing Tumor Immune Suppression

(2013) Greg T. Motz et al.   IMMUNITY

Endothelial adherens junctions at a glance

(2013) E. Dejana et al.   JOURNAL OF CELL SCIENCE

Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease

(2013) Michelle A Erickson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hemorrhagic Transformation after Ischemic Stroke in Animals and Humans

(2013) Glen C Jickling et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain

(2013) Hava Karsenty Avraham et al.   JOURNAL OF PATHOLOGY

Multi-center prediction of hemorrhagic transformation in acute ischemic stroke using permeability imaging features

(2013) Fabien Scalzo et al.   MAGNETIC RESONANCE IMAGING

Classic models for dynamic contrast-enhanced MRI

(2013) Steven P. Sourbron et al.   NMR IN BIOMEDICINE

A deficiency in CCR2+ monocytes: the hidden side of Alzheimer's disease

(2013) Gaëlle Naert et al.   Journal of Molecular Cell Biology

Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system

(2012) Catherine Larochelle et al.   BRAIN

Imaging Neuroinflammation after Stroke: Current Status of Cellular and Molecular MRI Strategies

(2012) Lisette H. Deddens et al.   CEREBROVASCULAR DISEASES

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression

(2012) Marco Reis et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A 1-42-RAGE Interaction Disrupts Tight Junctions of the Blood-Brain Barrier Via Ca2+-Calcineurin Signaling

(2012) S.-Y. Kook et al.   JOURNAL OF NEUROSCIENCE

Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell–Cell Junctions and Lung Metastasis

(2012) Tanja Holopainen et al.   JNCI-Journal of the National Cancer Institute

Aquaporin-4 mediates astrocyte response to β-amyloid

(2012) Wei Yang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The disturbed blood–brain barrier in human glioblastoma

(2012) Hartwig Wolburg et al.   MOLECULAR ASPECTS OF MEDICINE

Neuroinflammation and Blood-Brain Barrier Changes in Capillary Amyloid Angiopathy

(2012) Anna Carrano et al.   Neurodegenerative Diseases

Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice

(2011) Mario Merlini et al.   ACTA NEUROPATHOLOGICA

Caveolin-1 opens endothelial cell junctions by targeting catenins

(2011) Romy Kronstein et al.   CARDIOVASCULAR RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke

(2011) Kim M. Baeten et al.   Developmental Neurobiology

LSR defines cell corners for tricellular tight junction formation in epithelial cells

(2011) S. Masuda et al.   JOURNAL OF CELL SCIENCE

Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE

(2011) Veit Rothhammer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Loss of  4 Integrin Expression Differentially Affects the Homing of Th1 and Th17 Cells

(2011) S. Glatigny et al.   JOURNAL OF IMMUNOLOGY

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

Blood–Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease

(2011) Yi Yang et al.   STROKE

Sensory circumventricular organs in health and disease

(2010) Sílvia Sisó et al.   ACTA NEUROPATHOLOGICA

Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis

(2010) Áine C. Murphy et al.   BRAIN BEHAVIOR AND IMMUNITY

Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer

(2010) P. R. Lockman et al.   CLINICAL CANCER RESEARCH

Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo

(2010) Amanda M. Marchiando et al.   JOURNAL OF CELL BIOLOGY

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β-peptide elimination from the brain

(2010) Berislav V. Zlokovic et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer's disease

(2010) Erik Stomrud et al.   Alzheimers Research & Therapy

Cellular mechanisms of IL-17-induced blood-brain barrier disruption

(2009) Jula Huppert et al.   FASEB JOURNAL

Relative Recirculation

(2009) Shengping Wu et al.   INVESTIGATIVE RADIOLOGY

Caveolae-mediated Internalization of Occludin and Claudin-5 during CCL2-induced Tight Junction Remodeling in Brain Endothelial Cells

(2009) Svetlana M. Stamatovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid   Interaction with Receptor for Advanced Glycation End Products Up-Regulates Brain Endothelial CCR5 Expression and Promotes T Cells Crossing the Blood-Brain Barrier

(2009) M. Li et al.   JOURNAL OF IMMUNOLOGY

Near-infrared fluorescence imaging with fluorescently labeled albumin: A novel method for non-invasive optical imaging of blood–brain barrier impairment after focal cerebral ischemia in mice

(2009) Jan Klohs et al.   JOURNAL OF NEUROSCIENCE METHODS

Dynamic in vivo imaging of cerebral blood flow and blood–brain barrier permeability

(2009) Ofer Prager et al.   NEUROIMAGE

Early-Stage Investigations of Ultrasmall Superparamagnetic Iron Oxide-Induced Signal Change After Permanent Middle Cerebral Artery Occlusion in Mice

(2009) Virginie Desestret et al.   STROKE

Flt-1 Signaling in Macrophages Promotes Glioma Growth In vivo

(2008) M. Kerber et al.   CANCER RESEARCH

Inducible endothelial cell-specific gene expression in transgenic mouse embryos and adult mice

(2008) Urban Deutsch et al.   EXPERIMENTAL CELL RESEARCH

The Th17–ELR+CXC chemokine pathway is essential for the development of central nervous system autoimmune disease

(2008) Thaddeus Carlson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells

(2008) Ingunn M Stromnes et al.   NATURE MEDICINE

Gadolinium-based contrast agents and nephrogenic systemic fibrosis: a systematic review and meta-analysis

(2008) R. Agarwal et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Blood-brain barrier changes and cell invasion differ between therapeutic immune clearance of neurotrophic virus and CNS autoimmunity

(2008) M. J. Fabis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MRI Detection of Early Blood-Brain Barrier Disruption

(2008) Niels Hjort et al.   STROKE