Targeting insulin‐like growth factor‐1 receptor (IGF1R) for brain delivery of biologics

Defining the epitope of a blood–brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor

(2021) Joey Sheff et al.   Scientific Reports

In vivo near-infrared fluorescent optical imaging for CNS drug discovery

(2020) Maria J. Moreno et al.   Expert Opinion on Drug Discovery

A single-domain antibody inhibits SFTSV and mitigates virus-induced pathogenesis in vivo

(2020) Xilin Wu et al.   JCI Insight

Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human

(2020) Wandong Zhang et al.   Fluids and Barriers of the CNS

Brain Delivery of Single-Domain Antibodies: A Focus on VHH and VNAR

(2020) Elodie Pothin et al.   Pharmaceutics

Blood‐brain barrier transport using a high affinity, brain‐selective VNAR antibody targeting transferrin receptor 1

(2020) Pawel Stocki et al.   FASEB JOURNAL

Transferrin Receptor-Mediated Uptake at the Blood–Brain Barrier Is Not Impaired by Alzheimer’s Disease Neuropathology

(2019) Philippe Bourassa et al.   MOLECULAR PHARMACEUTICS

Galanin plays a role in antinociception via binding to galanin receptors in the nucleus accumbens of rats with neuropathic pain

(2019) Ying Zhang et al.   NEUROSCIENCE LETTERS

Adenovirus-Mediated Transduction of Insulin-Like Growth Factor 1 Protects Hippocampal Neurons from the Toxicity of Aβ Oligomers and Prevents Memory Loss in an Alzheimer Mouse Model

(2019) Maria Clara Selles et al.   MOLECULAR NEUROBIOLOGY

Intracellular sorting and transcytosis of the rat transferrin receptor antibody OX26 across the blood-brain barrier in vitro is dependent on its binding affinity

(2018) Arsalan S. Haqqani et al.   JOURNAL OF NEUROCHEMISTRY

Enhanced Delivery of Galanin Conjugates to the Brain through Bioengineering of the Anti-Transferrin Receptor Antibody OX26

(2018) George Thom et al.   MOLECULAR PHARMACEUTICS

Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling

(2018) Martin A. Rossotti et al.   BIOCHEMICAL JOURNAL

Emerging Technologies for Delivery of Biotherapeutics and Gene Therapy Across the Blood–Brain Barrier

(2018) Danica B. Stanimirovic et al.   BIODRUGS

Preclinical evaluation of intravenous NAX 810-2, a novel GalR2-preferring analog, for anticonvulsant efficacy and pharmacokinetics

(2017) Cameron S. Metcalf et al.   EPILEPSIA

Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression

(2017) Weikang Cai et al.   Nature Communications

Re-engineering therapeutic antibodies for Alzheimer’s disease as blood-brain barrier penetrating bi-specific antibodies

(2016) William M. Pardridge   EXPERT OPINION ON BIOLOGICAL THERAPY

Brain penetration, target engagement, and disposition of the blood–brain barrier-crossing bispecific antibody antagonist of metabotropic glutamate receptor type 1

(2016) Carl I. Webster et al.   FASEB JOURNAL

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies

(2016) Y. Joy Yu Zuchero et al.   NEURON

Insulin and insulin-like growth factor receptors in the brain: Physiological and pathological aspects

(2014) Haim Werner et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

A novel platform for engineering blood-brain barrier-crossing bispecific biologics

(2014) Graham K. Farrington et al.   FASEB JOURNAL

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

(2014) Nga Bien-Ly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

Altered cerebral vascular volumes and solute transport at the blood–brain barriers of two transgenic mouse models of Alzheimer's disease

(2014) Tuan Minh Do et al.   NEUROPHARMACOLOGY

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

Study of the transcytosis of an anti-transferrin receptor antibody with a Fab′ cargo across the blood–brain barrier in mice

(2013) Gemma Manich et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Brain Uptake of a Fluorescent Vector Targeting the Transferrin Receptor: A Novel Application of in Situ Brain Perfusion

(2013) Wael Alata et al.   MOLECULAR PHARMACEUTICS

Disaggregation of Amyloid Plaque in Brain of Alzheimer’s Disease Transgenic Mice with Daily Subcutaneous Administration of a Tetravalent Bispecific Antibody That Targets the Transferrin Receptor and the Abeta Amyloid Peptide

(2013) Rachita K. Sumbria et al.   MOLECULAR PHARMACEUTICS

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

(2013) J. A. Couch et al.   Science Translational Medicine

Multiplexed Evaluation of Serum and CSF Pharmacokinetics of Brain-Targeting Single-Domain Antibodies Using a NanoLC–SRM-ILIS Method

(2012) Arsalan S. Haqqani et al.   MOLECULAR PHARMACEUTICS

Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor

(2012) H. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anticonvulsant neuropeptides as drug leads for neurological diseases

(2011) Charles R. Robertson et al.   NATURAL PRODUCT REPORTS

IGF1R Signaling in Ewing Sarcoma Is Shaped by Clathrin-/Caveolin-Dependent Endocytosis

(2011) Ana Sofia Martins et al.   PLoS One

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

Type 1 Insulin-like Growth Factor Receptor Translocates to the Nucleus of Human Tumor Cells

(2010) T. Aleksic et al.   CANCER RESEARCH

Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS

(2010) Takeshi Nishijima et al.   NEURON

SUMOylation Mediates the Nuclear Translocation and Signaling of the IGF-1 Receptor

(2010) B. Sehat et al.   Science Signaling

Receptor-mediated therapeutic transport across the blood–brain barrier

(2009) Yun-Yan Wang et al.   Immunotherapy

Approaches to transport therapeutic drugs across the blood–brain barrier to treat brain diseases

(2009) Reinhard Gabathuler   NEUROBIOLOGY OF DISEASE

Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood–brain barrier: An in situ cerebral perfusion study

(2009) Melissa Ouellet et al.   NEUROCHEMISTRY INTERNATIONAL

Design, Synthesis, and Characterization of High-Affinity, Systemically-Active Galanin Analogues with Potent Anticonvulsant Activities

(2008) Grzegorz Bulaj et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aggregation-resistant VHs selected by in vitro evolution tend to have disulfide-bonded loops and acidic isoelectric points

(2008) M. Arbabi-Ghahroudi et al.   PROTEIN ENGINEERING DESIGN & SELECTION