Lysosomal Dysfunction and α-Synuclein Aggregation in Parkinson's Disease: Diagnostic Links
出版年份 2016 全文链接
标题
Lysosomal Dysfunction and α-Synuclein Aggregation in Parkinson's Disease: Diagnostic Links
作者
关键词
-
出版物
MOVEMENT DISORDERS
Volume 31, Issue 6, Pages 791-801
出版商
Wiley
发表日期
2016-02-29
DOI
10.1002/mds.26562
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Higher Cathepsin B Levels in Plasma in Alzheimer's Disease Compared to Healthy Controls
- (2017) Johan Sundelöf et al. JOURNAL OF ALZHEIMERS DISEASE
- From rare to common and back again: 60years of lysosomal dysfunction
- (2016) Maria Francisca Coutinho et al. MOLECULAR GENETICS AND METABOLISM
- Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies
- (2016) Maria Xilouri et al. MOVEMENT DISORDERS
- Lysosomal Storage Diseases: From Pathophysiology to Therapy
- (2015) Giancarlo Parenti et al. Annual Review of Medicine
- Epidemiology and diagnosis of lysosomal storage disorders; challenges of screening
- (2015) Sandra D.K. Kingma et al. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
- Glucocerebrosidase activity in Parkinson’s disease with and withoutGBAmutations
- (2015) Roy N. Alcalay et al. BRAIN
- Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in aDrosophilamodel of Parkinson's disease
- (2015) Mari Suzuki et al. HUMAN MOLECULAR GENETICS
- Mitochondrial impairment and oxidative stress compromise autophagosomal degradation of α-synuclein in oligodendroglial cells
- (2015) Katharina Pukaß et al. JOURNAL OF NEUROCHEMISTRY
- Glucocerebrosidase and Parkinson disease: Recent advances
- (2015) Anthony H.V. Schapira MOLECULAR AND CELLULAR NEUROSCIENCE
- Selective loss of glucocerebrosidase activity in sporadic Parkinson’s disease and dementia with Lewy bodies
- (2015) Davide Chiasserini et al. Molecular Neurodegeneration
- Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease
- (2015) Karen E. Murphy et al. MOVEMENT DISORDERS
- No evidence for substrate accumulation in Parkinson brains withGBAmutations
- (2015) Matthew E. Gegg et al. MOVEMENT DISORDERS
- Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease
- (2015) Edward J. Goetzl et al. NEUROLOGY
- The contribution of Niemann-Pick SMPD1 mutations to Parkinson disease in Ashkenazi Jews
- (2015) E. Dagan et al. PARKINSONISM & RELATED DISORDERS
- Cysteine cathepsins are essential in lysosomal degradation of α-synuclein
- (2015) Ryan P. McGlinchey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mannose 6-phosphate-independent Lysosomal Sorting of LIMP-2
- (2015) Judith Blanz et al. TRAFFIC
- Recent Insights into the Structure, Regulation, and Function of the V-ATPases
- (2015) Kristina Cotter et al. TRENDS IN BIOCHEMICAL SCIENCES
- Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates
- (2015) E-J Bae et al. Cell Death & Disease
- Gene-Wise Association of Variants in Four Lysosomal Storage Disorder Genes in Neuropathologically Confirmed Lewy Body Disease
- (2015) Lorraine N. Clark et al. PLoS One
- Autophagy in neuronal cells: general principles and physiological and pathological functions
- (2014) Markus Damme et al. ACTA NEUROPATHOLOGICA
- Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson’s disease
- (2014) Karen E. Murphy et al. BRAIN
- Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells
- (2014) Alisdair McNeill et al. BRAIN
- Proteomic analysis of cerebrospinal fluid extracellular vesicles: A comprehensive dataset
- (2014) Davide Chiasserini et al. Journal of Proteomics
- In-depth Characterization of the Cerebrospinal Fluid (CSF) Proteome Displayed Through the CSF Proteome Resource (CSF-PR)
- (2014) Astrid Guldbrandsen et al. MOLECULAR & CELLULAR PROTEOMICS
- Genetic Convergence of Parkinson’s Disease and Lysosomal Storage Disorders
- (2014) Hao Deng et al. MOLECULAR NEUROBIOLOGY
- Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease
- (2014) Lucilla Parnetti et al. MOVEMENT DISORDERS
- Sphingolipid lysosomal storage disorders
- (2014) Frances M. Platt NATURE
- Factors Influencing the Measurement of Lysosomal Enzymes Activity in Human Cerebrospinal Fluid
- (2014) Emanuele Persichetti et al. PLoS One
- LIMP-2 expression is critical for -glucocerebrosidase activity and -synuclein clearance
- (2014) M. Rothaug et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein
- (2014) Eun-Jin Bae et al. Nature Communications
- Lysosome sorting of β-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor
- (2014) Yuguang Zhao et al. Nature Communications
- Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease
- (2014) Sandra Tenreiro et al. PLoS Genetics
- Significant study of population stratification, sensitivity analysis and trim and fill analyses onGBAmutation and parkinson's disease
- (2013) Jie Liu et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- Saposin C Protects Glucocerebrosidase against α-Synuclein Inhibition
- (2013) Thai Leong Yap et al. BIOCHEMISTRY
- Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy
- (2013) Selcuk A. Tanik et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Parkinsonism syndrome in heterozygotes for Niemann–Pick C1
- (2013) Hans H. Kluenemann et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson's disease
- (2013) Sarah K. Abbott et al. MOVEMENT DISORDERS
- Lysosomal impairment in Parkinson's disease
- (2013) Benjamin Dehay et al. MOVEMENT DISORDERS
- Changes in endolysosomal enzyme activities in cerebrospinal fluid of patients with Parkinson's disease
- (2013) Karin D. van Dijk et al. MOVEMENT DISORDERS
- The role of autophagy in neurodegenerative disease
- (2013) Ralph A Nixon NATURE MEDICINE
- Cerebrospinal fluid biomarkers in Parkinson disease
- (2013) Lucilla Parnetti et al. Nature Reviews Neurology
- Lysosomal storage diseases—the horizon expands
- (2013) Rose-Mary Naaman Boustany Nature Reviews Neurology
- A rare lysosomal enzyme gene SMPD1 variant (p.R591C) associates with Parkinson's disease
- (2013) Jia-Nee Foo et al. NEUROBIOLOGY OF AGING
- Mutations in GBA and risk of Parkinson’s disease: a meta-analysis based on 25 case-control studies
- (2013) Xueye Mao et al. NEUROLOGICAL RESEARCH
- The p.L302P mutation in the lysosomal enzyme gene SMPD1 is a risk factor for Parkinson disease
- (2013) Z. Gan-Or et al. NEUROLOGY
- Lysosomal Network Proteins as Potential Novel CSF Biomarkers for Alzheimer’s Disease
- (2013) Andrea Armstrong et al. NEUROMOLECULAR MEDICINE
- Genetics of Parkinson's disease – state of the art, 2013
- (2013) Vincenzo Bonifati PARKINSONISM & RELATED DISORDERS
- Characterization of Acid Sphingomyelinase Activity in Human Cerebrospinal Fluid
- (2013) Christiane Mühle et al. PLoS One
- Lysosomal Membrane Proteins and Their Central Role in Physiology
- (2013) Michael Schwake et al. TRAFFIC
- Protein degradation pathways in Parkinson’s disease: curse or blessing
- (2012) Darius Ebrahimi-Fakhari et al. ACTA NEUROPATHOLOGICA
- Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains
- (2012) Matthew E. Gegg et al. ANNALS OF NEUROLOGY
- The neurobiology of glucocerebrosidase-associated parkinsonism: a positron emission tomography study of dopamine synthesis and regional cerebral blood flow
- (2012) Ozlem Goker-Alpan et al. BRAIN
- Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders
- (2012) Anja Schneider et al. CELL AND TISSUE RESEARCH
- Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism
- (2012) Flavia Antonucci et al. EMBO JOURNAL
- Glucocerebrosidase Mutations alter the endoplasmic reticulum and lysosomes in Lewy body disease
- (2012) Marzena Kurzawa-Akanbi et al. JOURNAL OF NEUROCHEMISTRY
- The link between the GBA gene and parkinsonism
- (2012) Ellen Sidransky et al. LANCET NEUROLOGY
- Membrane-bound α-synuclein interacts with glucocerebrosidase and inhibits enzyme activity
- (2012) Thai Leong Yap et al. MOLECULAR GENETICS AND METABOLISM
- Lysosome-dependent pathways as a unifying theme in Parkinson's disease
- (2012) George K. Tofaris MOVEMENT DISORDERS
- Membrane Trafficking in Osteoblasts and Osteoclasts: New Avenues for Understanding and Treating Skeletal Diseases
- (2012) Haibo Zhao TRAFFIC
- Mycobacteria and the Intraphagosomal Environment: Take It With a Pinch of Salt(s)!
- (2012) Thierry Soldati et al. TRAFFIC
- Chaperone-mediated autophagy: a unique way to enter the lysosome world
- (2012) Susmita Kaushik et al. TRENDS IN CELL BIOLOGY
- Lysosomal Acidification Mechanisms
- (2011) Joseph A. Mindell Annual Review of Physiology
- The endosome–lysosome pathway and information generation in the immune system
- (2011) Colin Watts BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
- (2011) Joseph R. Mazzulli et al. CELL
- Microautophagy: lesser-known self-eating
- (2011) Wen-wen Li et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways
- (2011) Michela Palmieri et al. HUMAN MOLECULAR GENETICS
- α-Synuclein Interacts with Glucocerebrosidase Providing a Molecular Link between Parkinson and Gaucher Diseases
- (2011) Thai Leong Yap et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Aggregation of α-synuclein in brain samples from subjects with glucocerebrosidase mutations
- (2011) Jae Hyuk Choi et al. MOLECULAR GENETICS AND METABOLISM
- Upregulation of cathepsin D in the caudate nucleus of primates with experimental parkinsonism
- (2011) Sowmya V Yelamanchili et al. Molecular Neurodegeneration
- Genetic and pathological links between Parkinson's disease and the lysosomal disorder Sanfilippo syndrome
- (2011) Sophie E. Winder-Rhodes et al. MOVEMENT DISORDERS
- Lysosomal storage disorders and Parkinson's disease: Gaucher disease and beyond
- (2011) Tamar Shachar et al. MOVEMENT DISORDERS
- Alteration of autophagosomal proteins (LC3, GABARAP and GATE-16) in Lewy body disease
- (2011) Kunikazu Tanji et al. NEUROBIOLOGY OF DISEASE
- CNS expression of glucocerebrosidase corrects -synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy
- (2011) S. P. Sardi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders
- (2010) Ozlem Goker-Alpan et al. ACTA NEUROPATHOLOGICA
- Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains
- (2010) Lydia Alvarez-Erviti et al. ARCHIVES OF NEUROLOGY
- Lysosomal membrane proteins: life between acid and neutral conditions: Figure 1
- (2010) Paul Saftig et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Lysosomal Degradation of α-Synucleinin Vivo
- (2010) Sally K. Mak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair
- (2010) Christina Tam et al. JOURNAL OF CELL BIOLOGY
- Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin
- (2010) A. Wahe et al. JOURNAL OF CELL SCIENCE
- Pathogenic Lysosomal Depletion in Parkinson's Disease
- (2010) B. Dehay et al. JOURNAL OF NEUROSCIENCE
- Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity
- (2010) Gaelle Lachenal et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- The proteome of lysosomes
- (2010) Bernd A. Schröder et al. PROTEOMICS
- The lysosome and neurodegenerative diseases
- (2009) L. Zhang et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease
- (2009) Juliane Neumann et al. BRAIN
- Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function
- (2009) Paul Saftig et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions
- (2009) Yaping Chu et al. NEUROBIOLOGY OF DISEASE
- Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
- (2009) E. Sidransky et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
- (2009) Valerie Cullen et al. Molecular Brain
- Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species†
- (2008) Daniel Sevlever et al. BIOCHEMISTRY
- Proteomics of the lysosome
- (2008) Torben Lübke et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells
- (2008) Tereza Vogiatzi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phenotype, diagnosis, and treatment of Gaucher's disease
- (2008) Gregory A Grabowski LANCET
- Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset
- (2008) W. C. Nichols et al. NEUROLOGY
- Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
- (2008) Liyan Qiao et al. Molecular Brain
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now