Misregulation of mitochondria–lysosome contact dynamics in Charcot–Marie–Tooth Type 2B disease Rab7 mutant sensory peripheral neurons

Parkin regulates amino acid homeostasis at mitochondria-lysosome (M/L) contact sites in Parkinson’s disease

(2023) Wesley Peng et al.   Science Advances

Mitochondrial Dynamics and Mitochondria-Lysosome Contacts in Neurogenetic Diseases

(2022) Jordi Pijuan et al.   Frontiers in Neuroscience

Dysregulation of organelle membrane contact sites in neurological diseases

(2022) Soojin Kim et al.   NEURON

Mitochondria-lysosome contact site dynamics and misregulation in neurodegenerative diseases

(2022) Jasmine Cisneros et al.   TRENDS IN NEUROSCIENCES

The Role of Impaired Mitochondrial Dynamics in MFN2-Mediated Pathology

(2022) Mashiat Zaman et al.   Frontiers in Cell and Developmental Biology

Mitochondria dysfunction in Charcot Marie Tooth 2B Peripheral Sensory Neuropathy

(2022) Yingli Gu et al.   Communications Biology

Mid51/Fis1 mitochondrial oligomerization complex drives lysosomal untethering and network dynamics

(2022) Yvette C. Wong et al.   JOURNAL OF CELL BIOLOGY

A SARM1/mitochondrial feedback loop drives neuropathogenesis in a Charcot-Marie-Tooth disease type 2A rat model

(2022) Yurie Yamada et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired Mitochondrial Mobility in Charcot-Marie-Tooth Disease

(2021) Cara R. Schiavon et al.   Frontiers in Cell and Developmental Biology

Mitochondria and calcium defects correlate with axonal dysfunction in GDAP1-related Charcot-Marie-Tooth mouse model

(2021) Azahara Civera-Tregón et al.   NEUROBIOLOGY OF DISEASE

Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease

(2021) Soojin Kim et al.   Nature Communications

Tubular microdomains of Rab7-endosomes retrieve TrkA, a mechanism disrupted in Charcot-Marie-Tooth 2B

(2021) R. Markworth et al.   JOURNAL OF CELL SCIENCE

tRNA overexpression rescues peripheral neuropathy caused by mutations in tRNA synthetase

(2021) Amila Zuko et al.   SCIENCE

Alteration of the late endocytic pathway in Charcot–Marie–Tooth type 2B disease

(2020) Roberta Romano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Reciprocal Regulation of Mitochondrial Fission and Fusion

(2020) Rasha Sabouny et al.   TRENDS IN BIOCHEMICAL SCIENCES

TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2+

(2020) Brian M. Woolums et al.   Nature Communications

Charcot-Marie-Tooth Type 2B: A New Phenotype Associated with a Novel RAB7A Mutation and Inhibited EGFR Degradation

(2020) Paola Saveri et al.   Cells

Mitochondria-lysosome contacts regulate mitochondrial Ca2+dynamics via lysosomal TRPML1

(2020) Wesley Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitofusin 2 Dysfunction and Disease in Mice and Men

(2020) Gerald W. Dorn   Frontiers in Physiology

Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons

(2019) Jean-Michel Cioni et al.   CELL

Regulation and Function of Mitochondria–Lysosome Membrane Contact Sites in Cellular Homeostasis

(2019) Yvette C. Wong et al.   TRENDS IN CELL BIOLOGY

Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model

(2019) Yueqin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Lysosomal Regulation of Inter-mitochondrial Contact Fate and Motility in Charcot-Marie-Tooth Type 2

(2019) Yvette C. Wong et al.   DEVELOPMENTAL CELL

Mitochondrial Dynamics and Its Involvement in Disease

(2019) David C. Chan   Annual Review of Pathology-Mechanisms of Disease

NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

(2019) D. Höglinger et al.   Nature Communications

Reducing CXCR4-mediated nociceptor hyperexcitability reverses painful diabetic neuropathy

(2018) Nirupa D. Jayaraj et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

(2018) Yvette C. Wong et al.   NATURE

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A

(2018) Agostinho G. Rocha et al.   SCIENCE

Single organelle dynamics linked to 3D structure by correlative live-cell imaging and 3D electron microscopy

(2018) Job Fermie et al.   TRAFFIC

Rab GTPase Function in Endosome and Lysosome Biogenesis

(2018) Lars Langemeyer et al.   TRENDS IN CELL BIOLOGY

Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore

(2018) Qixin Chen et al.   Small

Applying systems-level spectral imaging and analysis to reveal the organelle interactome

(2017) Alex M. Valm et al.   NATURE

Cell-permeable organic fluorescent probes for live-cell long-term super-resolution imaging reveal lysosome-mitochondrion interactions

(2017) Yubing Han et al.   Nature Communications

High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart

(2017) Daniel Aston et al.   Scientific Reports

Recent advances in the genetic neuropathies

(2016) Alexander M. Rossor et al.   CURRENT OPINION IN NEUROLOGY

Quantification of mitochondrial morphology in neurites of dopaminergic neurons using multiple parameters

(2016) Lyle Wiemerslage et al.   JOURNAL OF NEUROSCIENCE METHODS

Mice Hemizygous for a Pathogenic Mitofusin-2 Allele Exhibit Hind Limb/Foot Gait Deficits and Phenotypic Perturbations in Nerve and Muscle

(2016) Peter Bannerman et al.   PLoS One

Charcot-Marie-Tooth Disease and Related Hereditary Neuropathies: From Gene Function to Associated Phenotypes

(2014) D. Pareyson et al.   CURRENT MOLECULAR MEDICINE

Characterization of the mitofusin 2 R94W mutation in a knock-in mouse model

(2014) Alleene V. Strickland et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

CXCR4 Chemokine Receptor Signaling Mediates Pain in Diabetic Neuropathy

(2014) Daniela Maria Menichella et al.   Molecular Pain

Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

(2014) Koji Yamano et al.   eLife

A novel RAB7 mutation in a Chinese family with Charcot–Marie–Tooth type 2B disease

(2013) Xing Wang et al.   GENE

Defective Axonal Transport of Rab7 GTPase Results in Dysregulated Trophic Signaling

(2013) K. Zhang et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial morphology, topology, and membrane interactions in skeletal muscle: a quantitative three-dimensional electron microscopy study

(2012) Martin Picard et al.   JOURNAL OF APPLIED PHYSIOLOGY

Rab7 Mutants Associated with Charcot-Marie-Tooth Disease Cause Delayed Growth Factor Receptor Transport and Altered Endosomal and Nuclear Signaling

(2012) Soumik BasuRay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology

(2012) Kenta Onoue et al.   JOURNAL OF CELL SCIENCE

Autonomic nervous system involvement in a new CMT2B family

(2012) Fiore Manganelli et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Mitochondria as a central sensor for axonal degenerative stimuli

(2012) Felipe A. Court et al.   TRENDS IN NEUROSCIENCES

Expression of mitofusin 2R94Q in a transgenic mouse leads to Charcot–Marie–Tooth neuropathy type 2A

(2010) Romain Cartoni et al.   BRAIN

Differential Effects of TBC1D15 and Mammalian Vps39 on Rab7 Activation State, Lysosomal Morphology, and Growth Factor Dependence

(2010) Eigen R. Peralta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation

(2009) Brett A. McCray et al.   HUMAN MOLECULAR GENETICS

Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C

(2009) Michaela Auer-Grumbach et al.   NATURE GENETICS

Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4

(2009) Han-Xiang Deng et al.   NATURE GENETICS

Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C

(2009) Guida Landouré et al.   NATURE GENETICS

Control of mitochondrial transport and localization in neurons

(2009) Andrew F. MacAskill et al.   TRENDS IN CELL BIOLOGY

Functional Characterization of Rab7 Mutant Proteins Associated with Charcot-Marie-Tooth Type 2B Disease

(2008) M. R. Spinosa et al.   JOURNAL OF NEUROSCIENCE

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON