GLP-1 receptor agonism and GIP receptor antagonism induce substantial alterations in enteroendocrine and islet cell populations in obese high fat fed mice

GLP−1 receptor agonists for the treatment of obesity: Role as a promising approach

(2023) Jing-Yue Wang et al.   Frontiers in Endocrinology

PYY (3-36) protects against high fat feeding induced changes of pancreatic islet and intestinal hormone content and morphometry

(2023) A. Sridhar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Effect of dual glucose-dependent insulinotropic peptide/glucagon-like peptide-1 receptor agonist on weight loss in subjects with obesity

(2023) Isabella Zaffina et al.   Frontiers in Endocrinology

Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding

(2023) Alice Adriaenssens et al.   JCI Insight

Tirzepatide Once Weekly for the Treatment of Obesity

(2022) Ania M. Jastreboff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alpha-cell paracrine signaling in the regulation of beta-cell insulin secretion

(2022) Marlena M. Holter et al.   Frontiers in Endocrinology

Differential effects of RYGB surgery and best medical treatment for obesity-diabetes on intestinal and islet adaptations in obese-diabetic ZDSD rats

(2022) Ananyaa Sridhar et al.   PLoS One

Established and emerging roles peptide YY (PYY) and exploitation in obesity–diabetes

(2021) Ryan A. Lafferty et al.   Current Opinion in Endocrinology Diabetes and Obesity

GIP receptor deletion in mice confers resistance to HFD-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism

(2021) Geke Aline Boer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling

(2021) Qian Zhang et al.   Cell Metabolism

Evidence for the existence and potential roles of intra-islet glucagon-like peptide-1

(2021) Scott A. Campbell et al.   Islets

Benefits of Sustained Upregulated Unimolecular GLP-1 and CCK Receptor Signalling in Obesity-Diabetes

(2021) Neil Tanday et al.   Frontiers in Endocrinology

The Intestinal Epithelium – Fluid Fate and Rigid Structure From Crypt Bottom to Villus Tip

(2021) Vangelis Bonis et al.   Frontiers in Cell and Developmental Biology

The evolving story of incretins ( GIP and GLP ‐1) in metabolic and cardiovascular disease: A pathophysiological update

(2021) Michael A. Nauck et al.   DIABETES OBESITY & METABOLISM

Individual and combined effects of GIP and xenin on differentiation, glucose uptake and lipolysis in 3T3-L1 adipocytes

(2020) Andrew English et al.   BIOLOGICAL CHEMISTRY

Dose‐dependent efficacy of the glucose‐dependent insulinotropic polypeptide ( GIP) receptor antagonist GIP (3‐30) NH 2 on GIP actions in humans

(2020) Lærke Smidt Gasbjerg et al.   DIABETES OBESITY & METABOLISM

Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism

(2020) Elizabeth A. Killion et al.   Nature Communications

Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms

(2020) Jonathan E. Campbell   Molecular Metabolism

Function and mechanisms of enteroendocrine cells and gut hormones in metabolism

(2019) Fiona M. Gribble et al.   Nature Reviews Endocrinology

Effects of long-acting GIP, xenin and oxyntomodulin peptide analogues on alpha-cell transdifferentiation in insulin-deficient diabetic GluCreERT2;ROSA26-eYFP mice

(2019) Dipak Sarnobat et al.   PEPTIDES

Blockade of gastric inhibitory polypeptide (GIP) action as a novel means of countering insulin resistance in the treatment of obesity-diabetes

(2019) Nigel Irwin et al.   PEPTIDES

The influence of Glucose-dependent Insulinotropic Polypeptide (GIP) on human adipose tissue and fat metabolism: Implications for obesity, type 2 diabetes and Non-Alcoholic Fatty Liver Disease (NAFLD)

(2019) Sravan K. Thondam et al.   PEPTIDES

A GIP/xenin hybrid in combination with exendin-4 improves metabolic status in db/db diabetic mice and promotes enduring antidiabetic benefits in high fat fed mice

(2019) S.L. Craig et al.   BIOCHEMICAL PHARMACOLOGY

High fat diet induces microbiota-dependent silencing of enteroendocrine cells

(2019) Lihua Ye et al.   eLife

Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient

(2018) Joep Beumer et al.   NATURE CELL BIOLOGY

Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models

(2018) Elizabeth A. Killion et al.   Science Translational Medicine

Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism

(2018) Piotr A. Mroz et al.   Molecular Metabolism

Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium

(2016) Fiona M. Gribble et al.   Annual Review of Physiology

Functional and Molecular Adaptations of Enteroendocrine L-Cells in Male Obese Mice Are Associated With Preservation of Pancreatic α-Cell Function and Prevention of Hyperglycemia

(2016) Rodolphe Dusaulcy et al.   ENDOCRINOLOGY

Abundance and turnover of GLP-1 producing L-cells in ileal mucosa are not different in patients with and without type 2 diabetes

(2016) Kirsten Kampmann et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Islet distribution of Peptide YY and its regulatory role in primary mouse islets and immortalised rodent and human beta-cell function and survival

(2016) Dawood Khan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Intestinal and neuronal myenteric adaptations in the small intestine induced by a high-fat diet in mice

(2015) Angelica Soares et al.   BMC GASTROENTEROLOGY

Species-specific action of (Pro3)GIP - a full agonist at human GIP receptors, but a partial agonist and competitive antagonist at rat and mouse GIP receptors

(2015) A H Sparre-Ulrich et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sequential induction of beta cell rest and stimulation using stable GIP inhibitor and GLP-1 mimetic peptides improves metabolic control in C57BL/KsJ db/db mice

(2015) Varun Pathak et al.   DIABETOLOGIA

Antagonism of gastric inhibitory polypeptide (GIP) by palmitoylation of GIP analogues with N- and C-terminal modifications improves obesity and metabolic control in high fat fed mice

(2015) V. Pathak et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Incretin Receptor Null Mice Reveal Key Role of GLP-1 but Not GIP in Pancreatic Beta Cell Adaptation to Pregnancy

(2014) R. Charlotte Moffett et al.   PLoS One

Role of Endogenous GLP-1 and GIP in Beta Cell Compensatory Responses to Insulin Resistance and Cellular Stress

(2014) Srividya Vasu et al.   PLoS One

A novel acylated form of (d-Ala2)GIP with improved antidiabetic potential, lacking effect on body fat stores

(2013) Christine M.A. Martin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

GLP-1 Responses Are Heritable and Blunted in Acquired Obesity With High Liver Fat and Insulin Resistance

(2013) Niina Matikainen et al.   DIABETES CARE

Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells

(2013) A. M. Habib et al.   DIABETOLOGIA

Transcriptional Regulatory Factor X6 (Rfx6) Increases Gastric Inhibitory Polypeptide (GIP) Expression in Enteroendocrine K-cells and Is Involved in GIP Hypersecretion in High Fat Diet-induced Obesity

(2012) Kazuyo Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peripheral and Central GLP-1 Receptor Populations Mediate the Anorectic Effects of Peripherally Administered GLP-1 Receptor Agonists, Liraglutide and Exendin-4

(2011) Scott E. Kanoski et al.   ENDOCRINOLOGY

Peripheral-Specific Y2 Receptor Knockdown Protects Mice From High-Fat Diet–Induced Obesity

(2011) Yan-chuan Shi et al.   Obesity

Increased β-cell volume in mice fed a high-fat diet: A dynamic study over 12 months

(2011) Jonatan Ahrén et al.   Islets

Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice

(2010) David W. Porter et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Metabolic effects of sustained activation of the GLP-1 receptor alone and in combination with background GIP receptor antagonism in high fat-fed mice

(2009) N. Irwin et al.   DIABETES OBESITY & METABOLISM

The role of peptide YY in appetite regulation and obesity

(2008) Efthimia Karra et al.   JOURNAL OF PHYSIOLOGY-LONDON