The evolving story of incretins ( GIP and GLP ‐1) in metabolic and cardiovascular disease: A pathophysiological update
出版年份 2021 全文链接
标题
The evolving story of incretins (
GIP
and
GLP
‐1) in metabolic and cardiovascular disease: A pathophysiological update
作者
关键词
-
出版物
DIABETES OBESITY & METABOLISM
Volume 23, Issue S3, Pages 5-29
出版商
Wiley
发表日期
2021-07-26
DOI
10.1111/dom.14496
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling
- (2021) Qian Zhang et al. Cell Metabolism
- Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity
- (2021) Thomas A. Wadden et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Once-Weekly Semaglutide in Adults with Overweight or Obesity
- (2021) John P.H. Wilding et al. NEW ENGLAND JOURNAL OF MEDICINE
- GIP Receptor Antagonist, SKL-14959 Indicated Alteration of the Lipids Metabolism to Catabolism by the Inhibition of Plasma LPL Activity, Resulting in the Suppression of Weight Gain on Diets-Induced Obesity Mice
- (2021) Takashi Nakamura et al. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy
- Chronic peptide-based GIP receptor inhibition exhibits modest glucose metabolic changes in mice when administered either alone or combined with GLP-1 agonism
- (2021) Jason A. West et al. PLoS One
- GIP and GLP-1 Receptor Antagonism During a Meal in Healthy Individuals
- (2020) Lærke S Gasbjerg et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- How May GIP Enhance the Therapeutic Efficacy of GLP-1?
- (2020) Ricardo J. Samms et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Glucagon‐like peptide‐1 receptor is expressed in human and rodent testis
- (2020) Rosario Caltabiano et al. Andrology
- Liraglutide Ameliorates Erectile Dysfunction via Regulating Oxidative Stress, the RhoA/ROCK Pathway and Autophagy in Diabetes Mellitus
- (2020) Penghui Yuan et al. Frontiers in Pharmacology
- Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion
- (2020) Brandon L. Panaro et al. Molecular Metabolism
- Dose‐dependent efficacy of the glucose‐dependent insulinotropic polypeptide ( GIP) receptor antagonist GIP (3‐30) NH 2 on GIP actions in humans
- (2020) Lærke Smidt Gasbjerg et al. DIABETES OBESITY & METABOLISM
- A Pilot Study Examining the Effects of GLP-1 Receptor Blockade Using Exendin-(9,39) on Gastric Emptying and Caloric Intake in Subjects With and Without Bariatric Surgery
- (2020) Esi Kittah et al. Metabolic Syndrome and Related Disorders
- Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism
- (2020) Elizabeth A. Killion et al. Nature Communications
- Revisiting the Complexity of GLP-1 Action from Sites of Synthesis to Receptor Activation
- (2020) Brent A McLean et al. ENDOCRINE REVIEWS
- Using a reporter mouse to map known and novel sites of GLP-1 receptor expression in peripheral tissues of male mice
- (2020) Daniel B Andersen et al. ENDOCRINOLOGY
- Dual GIP and GLP-1 Receptor Agonist Tirzepatide Improves Beta-cell Function and Insulin Sensitivity in Type 2 Diabetes
- (2020) Melissa K Thomas et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Different mechanisms of GIP and GLP-1 action explain their different therapeutic efficacy in type 2 diabetes
- (2020) Eleonora Grespan et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms
- (2020) Jonathan E. Campbell Molecular Metabolism
- A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis
- (2020) Philip N. Newsome et al. NEW ENGLAND JOURNAL OF MEDICINE
- Separate and Combined Gluco-Metabolic Effects of Endogenous Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 in Healthy Individuals
- (2019) Lærke S. Gasbjerg et al. DIABETES
- Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease
- (2019) Shun He et al. NATURE
- Effects of combined GIP and GLP-1 infusion on energy intake, appetite and energy expenditure in overweight/obese individuals: a randomised, crossover study
- (2019) Natasha C. Bergmann et al. DIABETOLOGIA
- Effect of portal glucose sensing on incretin hormone secretion in a canine model
- (2019) Dale S Edgerton et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Free fatty acid receptors, G protein‐coupled receptor 120 and G protein‐coupled receptor 40, are essential for oil‐induced gastric inhibitory polypeptide secretion
- (2019) Akiko Sankoda et al. Journal of Diabetes Investigation
- Role of adipose tissue GLP-1R expression in metabolic improvement after bariatric surgery in patients with type 2 diabetes
- (2019) Miriam Ejarque et al. Scientific Reports
- The Glp-1 Analog Liraglutide Protects Against Angiotensin II and Pressure Overload-Induced Cardiac Hypertrophy via PI3K/Akt1 and AMPKa Signaling
- (2019) Ran Li et al. Frontiers in Pharmacology
- Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake
- (2019) Alice E. Adriaenssens et al. Cell Metabolism
- The rollercoaster history of using physiological and pharmacological properties of incretin hormones to develop diabetes medications with a convincing benefit-risk relationship
- (2019) Michael A. Nauck METABOLISM-CLINICAL AND EXPERIMENTAL
- Evaluation of the incretin effect in humans using GIP and GLP-1 receptor antagonists
- (2019) Lærke S. Gasbjerg et al. PEPTIDES
- Glucose-dependent insulinotropic polypeptide (GIP) and cardiovascular disease
- (2019) Sebastian M. Heimbürger et al. PEPTIDES
- Blockade of gastric inhibitory polypeptide (GIP) action as a novel means of countering insulin resistance in the treatment of obesity-diabetes
- (2019) Nigel Irwin et al. PEPTIDES
- Effects of sequential treatment with lixisenatide, insulin glargine, or their combination on meal‐related glycaemic excursions, insulin and glucagon secretion, and gastric emptying in patients with type 2 diabetes
- (2019) Juris J. Meier et al. DIABETES OBESITY & METABOLISM
- MANAGEMENT OF ENDOCRINE DISEASE: Are all GLP-1 agonists equal in the treatment of type 2 diabetes?
- (2019) Michael A Nauck et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Pharmacological antagonism of the incretin system protects against diet-induced obesity
- (2019) Berit Svendsen et al. Molecular Metabolism
- Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction
- (2018) John R. Ussher et al. Cell Metabolism
- Glucagon-like peptide-1 receptor expression in the human eye
- (2018) Josephine B. Hebsgaard et al. DIABETES OBESITY & METABOLISM
- Semaglutide, reduction in glycated haemoglobin and the risk of diabetic retinopathy
- (2018) Tina Vilsbøll et al. DIABETES OBESITY & METABOLISM
- Calcium-sensing receptor-mediated L-tryptophan-induced secretion of cholecystokinin and glucose-dependent insulinotropic peptide in swine duodenum
- (2018) Xiuying Zhao et al. Journal of Veterinary Science
- Glucose-dependent insulinotropic polypeptide (GIP) receptor antagonists as anti-diabetic agents
- (2018) Lærke Smidt Gasbjerg et al. PEPTIDES
- Cholinergic signaling mediates the effects of xenin-25 on secretion of pancreatic polypeptide but not insulin or glucagon in humans with impaired glucose tolerance
- (2018) Songyan Wang et al. PLoS One
- High Glycemic Index Metabolic Damage – a Pivotal Role of GIP and GLP-1
- (2018) Andreas F.H. Pfeiffer et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- The incretin hormone GIP is upregulated in patients with atherosclerosis and stabilizes plaques in ApoE −/− mice by blocking monocyte/macrophage activation
- (2018) Florian Kahles et al. Molecular Metabolism
- Sensing of L -Arginine by Gut-Expressed Calcium Sensing Receptor Stimulates Gut Satiety Hormones Cholecystokinin and Glucose-Dependent Insulinotropic Peptide Secretion in Pig Model
- (2018) Chao Wang et al. JOURNAL OF FOOD SCIENCE
- Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial
- (2018) Juan Pablo Frias et al. LANCET
- Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models
- (2018) Elizabeth A. Killion et al. Science Translational Medicine
- Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism
- (2018) Piotr A. Mroz et al. Molecular Metabolism
- Pro-inflammatory gene expression profile in obese adults with high plasma GIP levels
- (2017) J Góralska et al. INTERNATIONAL JOURNAL OF OBESITY
- Glucose-Dependent Insulinotropic Polypeptide Receptor Deficiency Leads to Impaired Bone Marrow Hematopoiesis
- (2017) Fernanda Dana Mantelmacher et al. JOURNAL OF IMMUNOLOGY
- 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial
- (2017) Carel W le Roux et al. LANCET
- Difference in protective effects of GIP and GLP-1 on endothelial cells according to cyclic adenosine monophosphate response
- (2017) Dong-Mee Lim et al. Experimental and Therapeutic Medicine
- Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob mice
- (2017) Satoko Shimazu-Kuwahara et al. Molecular Metabolism
- Effects of endogenous GLP-1 and GIP on glucose tolerance after Roux-en-Y gastric bypass surgery
- (2016) Maria S. Svane et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Central GIP signaling stimulates peripheral GIP release and promotes insulin and pancreatic polypeptide secretion in nonhuman primates
- (2016) Paul B. Higgins et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells
- (2016) Arianna Psichas et al. BRITISH JOURNAL OF PHARMACOLOGY
- Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes
- (2016) Åsa Segerstolpe et al. Cell Metabolism
- Suppressive Effects of Glucose-Dependent Insulinotropic Polypeptide on Cardiac Hypertrophy and Fibrosis in Angiotensin II-Infused Mouse Models
- (2016) Munenori Hiromura et al. CIRCULATION JOURNAL
- Acute renal haemodynamic effects of glucagon-like peptide-1 receptor agonist exenatide in healthy overweight men
- (2016) M. H. A. Muskiet et al. DIABETES OBESITY & METABOLISM
- Glucose-dependent insulinotropic peptide secretion is induced by inflammatory stimuli in an interleukin-1-dependent manner in mice
- (2016) F. Kahles et al. DIABETES OBESITY & METABOLISM
- Occurrence of nausea, vomiting and diarrhoea reported as adverse events in clinical trials studying glucagon-like peptide-1 receptor agonists: A systematic analysis of published clinical trials
- (2016) Karolin Bettge et al. DIABETES OBESITY & METABOLISM
- GPR119, a Major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Coacting in Synergy With FFA1 (GPR40)
- (2016) Jeppe H. Ekberg et al. ENDOCRINOLOGY
- Glucose-Dependent Insulinotropic Polypeptide Is Associated With Lower Low-Density Lipoprotein But Unhealthy Fat Distribution, Independent of Insulin: The ADDITION-PRO Study
- (2016) Cathrine Laustrup Møller et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Insulin Plays a Permissive Role for the Vasoactive Effect of GIP Regulating Adipose Tissue Metabolism in Humans
- (2016) Meena Asmar et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
- (2016) Steven P. Marso et al. NEW ENGLAND JOURNAL OF MEDICINE
- Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells
- (2016) Ramona Pais et al. PEPTIDES
- Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells
- (2016) Catherine E. Moss et al. PEPTIDES
- The blunted effect of glucose-dependent insulinotropic polypeptide in subcutaneous abdominal adipose tissue in obese subjects is partly reversed by weight loss
- (2016) M Asmar et al. Nutrition & Diabetes
- The incretin effect in healthy individuals and those with type 2 diabetes: physiology, pathophysiology, and response to therapeutic interventions
- (2016) Michael A Nauck et al. Lancet Diabetes & Endocrinology
- Activation of GLP-1 Receptor Promotes Bone Marrow Stromal Cell Osteogenic Differentiation through β-Catenin
- (2016) Jingru Meng et al. Stem Cell Reports
- The 2-monoacylglycerol moiety of dietary fat appears to be responsible for the fat-induced release of GLP-1 in humans
- (2015) Mette J Mandøe et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Gastric inhibitory polypeptide immunoneutralization attenuates development of obesity in mice
- (2015) Michael O. Boylan et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Renal extraction and acute effects of glucagon-like peptide-1 on central and renal hemodynamics in healthy men
- (2015) Ali Asmar et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Direct effect of incretin hormones on glucose and glycerol metabolism and hemodynamics
- (2015) Kristian Karstoft et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- GLP-1 Receptor Agonist Exenatide Attenuates the Detrimental Effects of Obesity on Inflammatory Profile in Testis and Sperm Quality in Mice
- (2015) Erhong Zhang et al. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
- Evidence of Extrapancreatic Glucagon Secretion in Man
- (2015) Asger Lund et al. DIABETES
- GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study
- (2015) Kristine Færch et al. DIABETES
- Contrasting Effects of Lixisenatide and Liraglutide on Postprandial Glycemic Control, Gastric Emptying, and Safety Parameters in Patients With Type 2 Diabetes on Optimized Insulin Glargine With or Without Metformin: A Randomized, Open-Label Trial
- (2015) Juris J. Meier et al. DIABETES CARE
- GIP increases adipose tissue expression and blood levels of MCP-1 in humans and links high energy diets to inflammation: a randomised trial
- (2015) Özlem Gögebakan et al. DIABETOLOGIA
- Expression and Distribution of Glucagon-Like Peptide-1 Receptor mRNA, Protein and Binding in the Male Nonhuman Primate (Macaca mulatta) Brain
- (2015) Kristy M. Heppner et al. ENDOCRINOLOGY
- Free Fatty Acid Receptor GPR120 Is Highly Expressed in Enteroendocrine K Cells of the Upper Small Intestine and Has a Critical Role in GIP Secretion After Fat Ingestion
- (2015) Kanako Iwasaki et al. ENDOCRINOLOGY
- Pre-Treatment With Glucagon-Like Peptide-1 Protects Against Ischemic Left Ventricular Dysfunction and Stunning Without a Detected Difference in Myocardial Substrate Utilization
- (2015) Liam M. McCormick et al. JACC-Cardiovascular Interventions
- Effect of Glucagon-like Peptide-1 on High-Glucose-induced Oxidative Stress and Cell Apoptosis in Human Endothelial Cells and Its Underlying Mechanism
- (2015) Rehua Wang et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- GLP1 and GIP cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness
- (2015) Berit Svendsen et al. JOURNAL OF ENDOCRINOLOGY
- Antagonism of gastric inhibitory polypeptide (GIP) by palmitoylation of GIP analogues with N- and C-terminal modifications improves obesity and metabolic control in high fat fed mice
- (2015) V. Pathak et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells
- (2015) Mohamed-Sami Trabelsi et al. Nature Communications
- Fructose induces glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and insulin secretion: Role of adenosine triphosphate-sensitive K+channels
- (2015) Yusuke Seino et al. Journal of Diabetes Investigation
- Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans
- (2014) Rune E. Kuhre et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Adipocyte Inflammation Is Essential for Healthy Adipose Tissue Expansion and Remodeling
- (2014) Ingrid Wernstedt Asterholm et al. Cell Metabolism
- Molecular Mechanisms of Glucose-Stimulated GLP-1 Secretion From Perfused Rat Small Intestine
- (2014) Rune E. Kuhre et al. DIABETES
- GLP-1 Secretion Is Increased by Inflammatory Stimuli in an IL-6-Dependent Manner, Leading to Hyperinsulinemia and Blood Glucose Lowering
- (2014) F. Kahles et al. DIABETES
- Effect of Exogenous Intravenous Administrations of GLP-1 and/or GIP on Circulating Pro-Atrial Natriuretic Peptide in Subjects With Different Stages of Glucose Tolerance: Figure 1
- (2014) Natalia Rudovich et al. DIABETES CARE
- Albiglutide does not impair the counter-regulatory hormone response to hypoglycaemia: a randomized, double-blind, placebo-controlled, stepped glucose clamp study in subjects with type 2 diabetes mellitus
- (2014) M. Hompesch et al. DIABETES OBESITY & METABOLISM
- Nutritional strategy to prevent fatty liver and insulin resistance independent of obesity by reducing glucose-dependent insulinotropic polypeptide responses in mice
- (2014) Farnaz Keyhani-Nejad et al. DIABETOLOGIA
- GLP-1 Receptor Localization in Monkey and Human Tissue: Novel Distribution Revealed With Extensively Validated Monoclonal Antibody
- (2014) Charles Pyke et al. ENDOCRINOLOGY
- Disruption of GIP/GIPR Axis in Human Adipose Tissue Is Linked to Obesity and Insulin Resistance
- (2014) Victòria Ceperuelo-Mallafré et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- GIP Contributes to Islet Trihormonal Abnormalities in Type 2 Diabetes
- (2014) Chee W. Chia et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss
- (2014) Anna Secher et al. JOURNAL OF CLINICAL INVESTIGATION
- KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state
- (2014) Hidetada Ogata et al. JOURNAL OF ENDOCRINOLOGY
- Long-Acting Glucose-Dependent Insulinotropic Polypeptide Ameliorates Obesity-Induced Adipose Tissue Inflammation
- (2014) Chen Varol et al. JOURNAL OF IMMUNOLOGY
- Glucagon-like-peptide-1 receptor expression in normal and diseased human thyroid and pancreas
- (2014) Beatrice Waser et al. MODERN PATHOLOGY
- A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
- (2014) Brian Finan et al. NATURE MEDICINE
- High saturated fatty acid intake induces insulin secretion by elevating gastric inhibitory polypeptide levels in healthy individuals
- (2014) Kazue Itoh et al. NUTRITION RESEARCH
- Expression of the Fatty Acid Receptor GPR120 in the Gut of Diet-Induced-Obese Rats and Its Role in GLP-1 Secretion
- (2014) Sarah Juel Paulsen et al. PLoS One
- Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac/PLC-ε pathway and modulated by endogenous H2S
- (2014) Vanitha Bala et al. Frontiers in Physiology
- Systemic bile acid sensing by G protein-coupled bile acid receptor 1 (GPBAR1) promotes PYY and GLP-1 release
- (2013) C Ullmer et al. BRITISH JOURNAL OF PHARMACOLOGY
- Incretin Action in the Pancreas: Potential Promise, Possible Perils, and Pathological Pitfalls
- (2013) D. J. Drucker DIABETES
- Comparative Effects of Prolonged and Intermittent Stimulation of the Glucagon-Like Peptide 1 Receptor on Gastric Emptying and Glycemia
- (2013) M. M. Umapathysivam et al. DIABETES
- Link Between GIP and Osteopontin in Adipose Tissue and Insulin Resistance
- (2013) E. Ahlqvist et al. DIABETES
- Secretion of Glucose-Dependent Insulinotropic Polypeptide in Patients With Type 2 Diabetes: Systematic review and meta-analysis of clinical studies
- (2013) S. Calanna et al. DIABETES CARE
- A novel long-acting glucose-dependent insulinotropic peptide analogue: enhanced efficacy in normal and diabetic rodents
- (2013) K. Tatarkiewicz et al. DIABETES OBESITY & METABOLISM
- Secretion of glucagon-like peptide-1 in patients with type 2 diabetes mellitus: systematic review and meta-analyses of clinical studies
- (2013) S. Calanna et al. DIABETOLOGIA
- Effects of induced hyperinsulinaemia with and without hyperglycaemia on measures of cardiac vagal control
- (2013) M. Berkelaar et al. DIABETOLOGIA
- Preserved GLP-1 and exaggerated GIP secretion in type 2 diabetes and relationships with triglycerides and ALT
- (2013) Marjan Alssema et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Glucose-dependent insulinotropic polypeptide has impaired effect on abdominal, subcutaneous adipose tissue metabolism in obese subjects
- (2013) M Asmar et al. INTERNATIONAL JOURNAL OF OBESITY
- Glucose-dependent Insulinotropic Polypeptide: Blood Glucose Stabilizing Effects in Patients With Type 2 Diabetes
- (2013) Mikkel B. Christensen et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- GLP-1 promotes angiogenesis in human endothelial cells in a dose-dependent manner, through the Akt, Src and PKC pathways
- (2013) Konstantinos N. Aronis et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Acute peripheral administration of synthetic human GLP-1 (7–36 amide) decreases circulating IL-6 in obese patients with type 2 diabetes mellitus: A potential role for GLP-1 in modulation of the diabetic pro-inflammatory state?
- (2013) Christina Daousi et al. REGULATORY PEPTIDES
- Glucagon-like peptide-1: effect on pro-atrial natriuretic peptide in healthy males
- (2013) Jeppe Skov et al. Endocrine Connections
- Role of fatty acid transport protein 4 in oleic acid-induced glucagon-like peptide-1 secretion from murine intestinal L cells
- (2012) M. A. Poreba et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Glucose-dependent insulinotropic polypeptide induces cytokine expression, lipolysis, and insulin resistance in human adipocytes
- (2012) Katharina Timper et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents
- (2012) C. E. Moss et al. DIABETOLOGIA
- Glucose-dependent insulinotropic peptide impairs insulin signaling via inducing adipocyte inflammation in glucose-dependent insulinotropic peptide receptor-overexpressing adipocytes
- (2012) Yaohui Nie et al. FASEB JOURNAL
- Glucose-dependent Insulinotropic Polypeptide (GIP) Inhibits Signaling Pathways of Advanced Glycation End Products (AGEs) in Endothelial Cells via its Antioxidative Properties
- (2012) A. Ojima et al. HORMONE AND METABOLIC RESEARCH
- The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine
- (2012) Oliver J. Mace et al. JOURNAL OF PHYSIOLOGY-LONDON
- Glucose-Dependent Insulinotropic Polypeptide Prevents the Progression of Macrophage-Driven Atherosclerosis in Diabetic Apolipoprotein E-Null Mice
- (2012) Yukinori Nogi et al. PLoS One
- GIP-Overexpressing Mice Demonstrate Reduced Diet-Induced Obesity and Steatosis, and Improved Glucose Homeostasis
- (2012) Su-Jin Kim et al. PLoS One
- Glucagon-like peptide-1 activates endothelial nitric oxide synthase in human umbilical vein endothelial cells
- (2011) Li Ding et al. ACTA PHARMACOLOGICA SINICA
- A Pilot Study to Assess Whether Glucagon-Like Peptide-1 Protects the Heart From Ischemic Dysfunction and Attenuates Stunning After Coronary Balloon Occlusion in Humans
- (2011) Philip A. Read et al. Circulation-Cardiovascular Interventions
- The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY)
- (2011) R.E. Steinert et al. CLINICAL NUTRITION
- Glucose-Dependent Insulinotropic Polypeptide: A Bifunctional Glucose-Dependent Regulator of Glucagon and Insulin Secretion in Humans
- (2011) M. Christensen et al. DIABETES
- GIP Does Not Potentiate the Antidiabetic Effects of GLP-1 in Hyperglycemic Patients With Type 2 Diabetes
- (2011) N. Mentis et al. DIABETES
- Rapid Tachyphylaxis of the Glucagon-Like Peptide 1-Induced Deceleration of Gastric Emptying in Humans
- (2011) M. A. Nauck et al. DIABETES
- Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2
- (2011) G. Tolhurst et al. DIABETES
- Study of the Potential Association of Adipose Tissue GLP-1 Receptor with Obesity and Insulin Resistance
- (2011) Joan Vendrell et al. ENDOCRINOLOGY
- Cardioprotection against ischaemia induced by dobutamine stress using glucagon-like peptide-1 in patients with coronary artery disease
- (2011) Philip A Read et al. HEART
- Transgenic Rescue of Adipocyte Glucose-dependent Insulinotropic Polypeptide Receptor Expression Restores High Fat Diet-induced Body Weight Gain
- (2011) Randi Ugleholdt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Incretin Hormone and Insulin Responses to OralVersusIntravenous Lipid Administration in Humans
- (2011) Ola Lindgren et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Impaired Regulation of the Incretin Effect in Patients with Type 2 Diabetes
- (2011) Jonatan I. Bagger et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Glutamine Reduces Postprandial Glycemia and Augments the Glucagon-Like Peptide-1 Response in Type 2 Diabetes Patients
- (2011) Dorit Samocha-Bonet et al. JOURNAL OF NUTRITION
- Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
- (2011) Helga Ellingsgaard et al. NATURE MEDICINE
- Insulin-sensitive obesity
- (2010) Nora Klöting et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Cardiovascular and metabolic effects of 48-h glucagon-like peptide-1 infusion in compensated chronic patients with heart failure
- (2010) Mads Halbirk et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Physiologic and Pharmacologic Modulation of Glucose-Dependent Insulinotropic Polypeptide (GIP) Receptor Expression in -Cells by Peroxisome Proliferator-Activated Receptor (PPAR)- Signaling: Possible Mechanism for the GIP Resistance in Type 2 Diabetes
- (2010) D. Gupta et al. DIABETES
- Is the Diminished Incretin Effect in Type 2 Diabetes Just an Epi-Phenomenon of Impaired -Cell Function?
- (2010) J. J. Meier et al. DIABETES
- Glucose-Dependent Insulinotropic Polypeptide May Enhance Fatty Acid Re-esterification in Subcutaneous Abdominal Adipose Tissue in Lean Humans
- (2010) M. Asmar et al. DIABETES
- Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?
- (2010) M. A. Nauck et al. DIABETOLOGIA
- GIP increases human adipocyte LPL expression through CREB and TORC2-mediatedtrans-activation of theLPLgene
- (2010) Su-Jin Kim et al. JOURNAL OF LIPID RESEARCH
- Exendin-4 stimulates proliferation of human coronary artery endothelial cells through eNOS-, PKA- and PI3K/Akt-dependent pathways and requires GLP-1 receptor
- (2010) Ö. Erdogdu et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- A GIP Receptor Agonist Exhibits β-Cell Anti-Apoptotic Actions in Rat Models of Diabetes Resulting in Improved β-Cell Function and Glycemic Control
- (2010) Scott B. Widenmaier et al. PLoS One
- On the role of glucose-dependent insulintropic polypeptide in postprandial metabolism in humans
- (2009) Meena Asmar et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Exogenous Glucose-Dependent Insulinotropic Polypeptide Worsens Post prandial Hyperglycemia in T ype 2 Diabetes
- (2009) C. W. Chia et al. DIABETES
- GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell
- (2009) L. M. Lauffer et al. DIABETES
- Metabolic effects of diets differing in glycaemic index depend on age and endogenous glucose-dependent insulinotrophic polypeptide in mice
- (2009) F. Isken et al. DIABETOLOGIA
- The effects of GLP-1 infusion in the hepatic portal region on food intake
- (2009) Dong-Hoon Kim et al. REGULATORY PEPTIDES
- Targeted Ablation of Glucose-dependent Insulinotropic Polypeptide-producing Cells in Transgenic Mice Reduces Obesity and Insulin Resistance Induced by a High Fat Diet
- (2008) Matthew C. Althage et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expression of the GLP-1 Receptor in Mouse, Rat, and Human Pancreas
- (2008) Ditte Tornehave et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study
- (2008) Daniel J Drucker et al. LANCET
- Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic β cells
- (2008) Toshiki Tanaka et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- GLP-1 suppresses gastrointestinal motility and inhibits the migrating motor complex in healthy subjects and patients with irritable bowel syndrome
- (2008) p. m. hellström et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Prolonged GIP receptor activation using stable mini-PEGylated GIP improves glucose homeostasis and beta-cell function in age-related glucose intolerance
- (2008) Barry D. Kerr et al. PEPTIDES
- The Murine Glucagon-Like Peptide-1 Receptor Is Essential for Control of Bone Resorption
- (2007) Chizumi Yamada et al. ENDOCRINOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started