Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism
出版年份 2020 全文链接
标题
Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism
作者
关键词
-
出版物
Nature Communications
Volume 11, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-10-05
DOI
10.1038/s41467-020-18751-8
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- A Randomized, Controlled Trial of Liraglutide for Adolescents with Obesity
- (2020) Aaron S. Kelly et al. NEW ENGLAND JOURNAL OF MEDICINE
- Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake
- (2019) Alice E. Adriaenssens et al. Cell Metabolism
- Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition
- (2019) Kentaro Kaneko et al. JOURNAL OF CLINICAL INVESTIGATION
- Glucose-Dependent Insulinotropic Polypeptide Receptor Therapies For The Treatment Of Obesity, Do Agonists = Antagonists?
- (2019) Elizabeth A Killion et al. ENDOCRINE REVIEWS
- Human GIP(3-30)NH 2 inhibits G protein-dependent as well as G protein-independent signaling and is selective for the GIP receptor with high-affinity binding to primate but not rodent GIP receptors
- (2018) Maria Buur Nordskov Gabe et al. BIOCHEMICAL PHARMACOLOGY
- GPCR desensitization: Acute and prolonged phases
- (2018) Sudarshan Rajagopal et al. CELLULAR SIGNALLING
- Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial
- (2018) Juan Pablo Frias et al. LANCET
- Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models
- (2018) Elizabeth A. Killion et al. Science Translational Medicine
- Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism
- (2018) Piotr A. Mroz et al. Molecular Metabolism
- Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
- (2017) Valérie Turcot et al. NATURE GENETICS
- Reappraisal of GIP Pharmacology for Metabolic Diseases
- (2016) Brian Finan et al. TRENDS IN MOLECULAR MEDICINE
- Downregulation of a GPCR by β-Arrestin2-Mediated Switch from an Endosomal to a TGN Recycling Pathway
- (2016) Nazish Abdullah et al. Cell Reports
- Chronic Reduction of GIP Secretion Alleviates Obesity and Insulin Resistance Under High-Fat Diet Conditions
- (2014) D. Nasteska et al. DIABETES
- A Naturally Occurring GIP Receptor Variant Undergoes Enhanced Agonist-Induced Desensitization, Which Impairs GIP Control of Adipose Insulin Sensitivity
- (2014) S. Mohammad et al. MOLECULAR AND CELLULAR BIOLOGY
- Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- (2013) Sonja I Berndt et al. NATURE GENETICS
- Resistin Knockout Mice Exhibit Impaired Adipocyte Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR) Expression
- (2012) S.-J. Kim et al. DIABETES
- Gipr Is Essential for Adrenocortical Steroidogenesis; However, Corticosterone Deficiency Does Not Mediate the Favorable Metabolic Phenotype of Gipr-/- Mice
- (2011) H. E. Bates et al. DIABETES
- Pleiotropic Effects of GIP on Islet Function Involve Osteopontin
- (2011) V. Lyssenko et al. DIABETES
- Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
- (2010) Richa Saxena et al. NATURE GENETICS
- Pharmacological Characterization of Human Incretin Receptor Missense Variants
- (2009) J.-P. Fortin et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Inhibition of GIP signaling modulates adiponectin levels under high-fat diet in mice
- (2008) Rei Naitoh et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Targeted Ablation of Glucose-dependent Insulinotropic Polypeptide-producing Cells in Transgenic Mice Reduces Obesity and Insulin Resistance Induced by a High Fat Diet
- (2008) Matthew C. Althage et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome
- (2008) David P Macfarlane et al. JOURNAL OF ENDOCRINOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now