Ube2L6 Promotes M1 Macrophage Polarization in High-Fat Diet-Fed Obese Mice via ISGylation of STAT1 to Trigger STAT1 Activation

Adipose tissue macrophage in obesity-associated metabolic diseases

(2022) Jingfei Yao et al.   Frontiers in Immunology

IFIH1/IRF1/STAT1 promotes sepsis associated inflammatory lung injury via activating macrophage M1 polarization

(2022) Ailing Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A Prediction Model of the Incidence of Type 2 Diabetes in Individuals with Abdominal Obesity: Insights from the General Population

(2022) Caixia Tan et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

The good and bad of adipose tissue macrophage exosomes in obesity

(2021) Andrew S. Greenberg et al.   Cell Metabolism

Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity

(2021) Andrew D. Hildreth et al.   NATURE IMMUNOLOGY

Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection

(2021) Deeksha Munnur et al.   NATURE IMMUNOLOGY

ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A Review

(2021) Mengdi Zhang et al.   Frontiers in Cell and Developmental Biology

UBE2L6 is Involved in Cisplatin Resistance by Regulating the Transcription of ABCB6

(2020) Midori Murakami et al.   Anti-Cancer Agents in Medicinal Chemistry

E2 ubiquitin-conjugating enzyme UBE2L6 promotes Senecavirus A proliferation by stabilizing the viral RNA polymerase

(2020) Liang Li et al.   PLoS Pathogens

Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis

(2020) Weiping Wei et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA‐induced differentiation of leukemic cells

(2019) Nina Orfali et al.   Molecular Oncology

UHRF1 epigenetically down-regulates UbcH8 to inhibit apoptosis in cervical cancer cells

(2018) Qishu Zhang et al.   CELL CYCLE

Biochemical characterization of a novel tyrosine phenol-lyase from Fusobacterium nucleatum for highly efficient biosynthesis of l -DOPA

(2018) Ren-Chao Zheng et al.   ENZYME AND MICROBIAL TECHNOLOGY

Ectopic fat obesity presents the greatest risk for incident type 2 diabetes: a population-based longitudinal study

(2018) Takuro Okamura et al.   INTERNATIONAL JOURNAL OF OBESITY

ISG'ylation increases stability of numerous proteins including Stat1, which prevents premature termination of immune response in LPS-stimulated microglia

(2018) Piotr Przanowski et al.   NEUROCHEMISTRY INTERNATIONAL

Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite?

(2018) John I. Malone et al.   PEDIATRIC DIABETES

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Adipose tissue macrophages: going off track during obesity

(2016) Lily Boutens et al.   DIABETOLOGIA

Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus

(2016) Alexandra Kautzky-Willer et al.   ENDOCRINE REVIEWS

Macrophages, Immunity, and Metabolic Disease

(2014) Joanne C. McNelis et al.   IMMUNITY

A decade of progress in adipose tissue macrophage biology

(2014) Andrea A. Hill et al.   IMMUNOLOGICAL REVIEWS

Enhanced ROS production and oxidative damage in subcutaneous white adipose tissue mitochondria in obese and type 2 diabetes subjects

(2014) Mrittika Chattopadhyay et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Origins and Drivers of Insulin Resistance

(2013) Andrew M.F. Johnson et al.   CELL

Identification of a Loss-of-Function Mutation in Ube2l6 Associated With Obesity Resistance

(2013) Genevieve Marcelin et al.   DIABETES

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification

(2010) H. X. Shi et al.   MOLECULAR AND CELLULAR BIOLOGY