Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection

IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis

(2021) Shuai Yan et al.   JOURNAL OF CLINICAL INVESTIGATION

The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles

(2020) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1

(2020) Akhee Sabiha Jahan et al.   Cell Reports

A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion

(2020) Min Zhang et al.   CELL

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming

(2020) Meike Kespohl et al.   Science Advances

Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing

(2020) Wen Wen et al.   Cell Discovery

The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease

(2020) Dennis McGonagle et al.   AUTOIMMUNITY REVIEWS

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

(2020) Donghyuk Shin et al.   NATURE

Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins

(2020) Caleb D. Swaim et al.   Cell Reports

Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles

(2020) Ming Yuan Li et al.   Nature Communications

Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity

(2020) Adan Pinto-Fernandez et al.   BRITISH JOURNAL OF CANCER

Downregulation of MHC Class I Expression by Influenza A and B Viruses

(2019) Marios Koutsakos et al.   Frontiers in Immunology

The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection

(2019) Yifeng Zhang et al.   Nature Communications

ISG15 in antiviral immunity and beyond

(2018) Yi-Chieh Perng et al.   NATURE REVIEWS MICROBIOLOGY

Beyond ISGlylation: Functions of Free Intracellular and Extracellular ISG15

(2017) Paula Fernandes dos Santos et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Extracellular ISG15 Signals Cytokine Secretion through the LFA-1 Integrin Receptor

(2017) Caleb D. Swaim et al.   MOLECULAR CELL

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

(2017) Rudragouda Channappanavar et al.   Seminars in Immunopathology

ISG15: In Sickness and in Health

(2017) Mark Hermann et al.   TRENDS IN IMMUNOLOGY

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification

(2016) Jong Ho Park et al.   Nature Communications

Secretory autophagy

(2015) Marisa Ponpuak et al.   CURRENT OPINION IN CELL BIOLOGY

Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8+ T cells

(2015) Zhongfang Wang et al.   Nature Communications

ISG15 counteracts Listeria monocytogenes infection

(2015) Lilliana Radoshevich et al.   eLife

Novel Mode of ISG15-Mediated Protection against Influenza A Virus and Sendai Virus in Mice

(2014) David J. Morales et al.   JOURNAL OF VIROLOGY

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

(2014) Xianqin Zhang et al.   NATURE

Pathogenic potential of interferon αβ in acute influenza infection

(2014) Sophia Davidson et al.   Nature Communications

Type I Interferon Imposes a TSG101/ISG15 Checkpoint at the Golgi for Glycoprotein Trafficking during Influenza Virus Infection

(2013) Sumana Sanyal et al.   Cell Host & Microbe

Pathogenesis of influenza-induced acute respiratory distress syndrome

(2013) Kirsty R Short et al.   LANCET INFECTIOUS DISEASES

Response of Primary Human Airway Epithelial Cells to Influenza Infection: A Quantitative Proteomic Study

(2012) Andrea L. Kroeker et al.   JOURNAL OF PROTEOME RESEARCH

Innate Immune Response of Human Alveolar Macrophages during Influenza A Infection

(2012) Jieru Wang et al.   PLoS One

Mycobacterial Disease and Impaired IFN-  Immunity in Humans with Inherited ISG15 Deficiency

(2012) D. Bogunovic et al.   SCIENCE

Influenza-induced innate immunity: regulators of viral replication, respiratory tract pathology & adaptive immunity

(2011) Karen L Oslund et al.   Future Virology

Viral Replication and Innate Host Responses in Primary Human Alveolar Epithelial Cells and Alveolar Macrophages Infected with Influenza H5N1 and H1N1 Viruses

(2011) W. C. L. Yu et al.   JOURNAL OF VIROLOGY

Induction and evasion of type I interferon responses by influenza viruses

(2011) Adolfo García-Sastre   VIRUS RESEARCH

Critical Role of Airway Macrophages in Modulating Disease Severity during Influenza Virus Infection of Mice

(2010) M. D. Tate et al.   JOURNAL OF VIROLOGY

ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells

(2010) C. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-Induced ISG15 Conjugation Inhibits Influenza A Virus Gene Expression and Replication in Human Cells

(2009) T.-Y. Hsiang et al.   JOURNAL OF VIROLOGY

The Pathology of Influenza Virus Infections

(2008) Jeffery K. Taubenberger et al.   Annual Review of Pathology-Mechanisms of Disease