E2 ubiquitin-conjugating enzyme UBE2L6 promotes Senecavirus A proliferation by stabilizing the viral RNA polymerase

Isolation of Three Novel Senecavirus A Strains and Recombination Analysis Among Senecaviruses in China

(2020) Zhenhua Guo et al.   Frontiers in Veterinary Science

A functional variant in UBE2L3 contributes to HBV infection and maintains cccDNA stability by inducing degradation of APOBEC3A protein

(2019) Li Zhou et al.   HEPATOLOGY

MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment

(2019) Sathish Kumar et al.   Cell Reports

Monoclonal antibody against EV71 3Dpol inhibits the polymerase activity of RdRp and virus replication

(2019) Yaoming Li et al.   BMC IMMUNOLOGY

RNF8 is responsible for ATRA resistance in variant acute promyelocytic leukemia with GTF2I/RARA fusion, and inhibition of the ubiquitin–proteasome pathway contributes to the reversion of ATRA resistance

(2019) Wenzhe Yan et al.   Cancer Cell International

Adenovirus E1B-55K targets SMARCAL1 for degradation during infection and modulates cellular DNA replication

(2019) Reshma Nazeer et al.   JOURNAL OF VIROLOGY

The ubiquitin-proteasome system is necessary for the replication of duck Tembusu virus

(2019) Kaikai Han et al.   MICROBIAL PATHOGENESIS

E3 ligase ASB8 promotes porcine reproductive and respiratory syndrome virus proliferation by stabilizing the viral Nsp1α protein and degrading host IKKβ kinase

(2019) Ruiqiao Li et al.   VIROLOGY

The Present and Future of Novel Protein Degradation Technology

(2019) Liwen Xia et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Aryl hydrocarbon receptor (AhR) regulates adipocyte differentiation by assembling CRL4B ubiquitin ligase to target PPARγ for proteasomal degradation

(2019) Hao Dou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Live Attenuated Vaccine Candidate Protects Against Heterologous Senecavirus A Challenge

(2019) Bishwas Sharma et al.   Frontiers in Immunology

Towards Computational Models of Identifying Protein Ubiquitination Sites

(2018) Lidong Wang et al.   CURRENT DRUG TARGETS

Stabilization of p27Kip1/CDKN1B by UBCH7/UBE2L3 catalyzed ubiquitinylation: a new paradigm in cell-cycle control

(2018) Elizabeth A. Whitcomb et al.   FASEB JOURNAL

Seneca Valley Virus 3C protease negatively regulates the type I interferon pathway by acting as a viral deubiquitinase

(2018) Qiao Xue et al.   ANTIVIRAL RESEARCH

Encephalomyocarditis virus 2C protein antagonizes interferon-β signaling pathway through interaction with MDA5

(2018) Liang Li et al.   ANTIVIRAL RESEARCH

Genome-wide CRISPR Analysis Identifies Substrate-Specific Conjugation Modules in ER-Associated Degradation

(2018) Dara E. Leto et al.   MOLECULAR CELL

N 6-methyladenosine modification and METTL3 modulate enterovirus 71 replication

(2018) Haojie Hao et al.   NUCLEIC ACIDS RESEARCH

RIG-I is responsible for activation of type I interferon pathway in Seneca Valley virus-infected porcine cells to suppress viral replication

(2018) Pengfei Li et al.   Virology Journal

Isolation and phylogenetic analysis of an emerging Senecavirus A in China, 2017

(2018) Cun Liu et al.   INFECTION GENETICS AND EVOLUTION

Emergence and whole-genome sequence of Senecavirus A in Colombia

(2017) D. Sun et al.   Transboundary and Emerging Diseases

Substrate Ubiquitination Controls the Unfolding Ability of the Proteasome

(2016) Eden L. Reichard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathological, Immunohistochemical and Molecular Findings Associated with Senecavirus A-Induced Lesions in Neonatal Piglets

(2016) R.A. Leme et al.   JOURNAL OF COMPARATIVE PATHOLOGY

SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication

(2016) Yan Liu et al.   JOURNAL OF VIROLOGY

SCFFbl12Increases p21Waf1/Cip1Expression Level through Atypical Ubiquitin Chain Synthesis

(2016) Fuminori Tsuruta et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation

(2016) Bo Shu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ELL targets c-Myc for proteasomal degradation and suppresses tumour growth

(2016) Yu Chen et al.   Nature Communications

RNF4-Dependent Oncogene Activation by Protein Stabilization

(2016) Jane J. Thomas et al.   Cell Reports

Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus Regulators

(2016) Ye Ji Kim et al.   PLoS Pathogens

Proteomics Analysis of EV71-Infected Cells Reveals the Involvement of Host Protein NEDD4L in EV71 Replication

(2015) Rei-Lin Kuo et al.   JOURNAL OF PROTEOME RESEARCH

The nonstructural protein 11 of porcine reproductive and respiratory syndrome virus inhibits NF-κB signaling by means of its deubiquitinating activity

(2015) Dang Wang et al.   MOLECULAR IMMUNOLOGY

Senecavirus A: An Emerging Vesicular Infection in Brazilian Pig Herds

(2015) R. A. Leme et al.   Transboundary and Emerging Diseases

Identification and Complete Genome of Seneca Valley Virus in Vesicular Fluid and Sera of Pigs Affected with Idiopathic Vesicular Disease, Brazil

(2015) F. A. Vannucci et al.   Transboundary and Emerging Diseases

Epigenetic downregulation of the ISG15–conjugating enzyme UbcH8 impairs lipolysis and correlates with poor prognosis in nasopharyngeal carcinoma

(2015) Xiaoying Zhou et al.   Oncotarget

Construction and characterization of an infectious cDNA clone of encephalomyocarditis virus from pigs in China

(2014) Puxian Fang et al.   ARCHIVES OF VIROLOGY

The Ubiquitin-Conjugating Enzyme, UbcM2, Is Restricted to Monoubiquitylation by a Two-Fold Mechanism That Involves Backside Residues of E2 and Lys48 of Ubiquitin

(2014) Linda Nguyen et al.   BIOCHEMISTRY

Curcumin inhibits the replication of enterovirus 71 in vitro

(2014) Ying Qin et al.   Acta Pharmaceutica Sinica B

Structural Features of a Picornavirus Polymerase Involved in the Polyadenylation of Viral RNA

(2013) B. J. Kempf et al.   JOURNAL OF VIROLOGY

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

(2012) Benjamin Stieglitz et al.   EMBO REPORTS

Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation

(2011) Gabriel Tsz-Mei Lok et al.   NUCLEIC ACIDS RESEARCH

Ubiquitin: Same Molecule, Different Degradation Pathways

(2010) Michael J. Clague et al.   CELL

The ubiquitous role of ubiquitin in the DNA damage response

(2010) Abdallah Al-Hakim et al.   DNA REPAIR

The E2 Ubiquitin-conjugating Enzymes Direct Polyubiquitination to Preferred Lysines

(2010) Yael David et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cysteine Protease Domain of Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 2 Possesses Deubiquitinating and Interferon Antagonism Functions

(2010) Z. Sun et al.   JOURNAL OF VIROLOGY

Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase

(2010) P. Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of the UbcH8−Ubiquitin Complex Shows a Unique Ubiquitin Interaction Site

(2009) Stephanie A. Serniwka et al.   BIOCHEMISTRY

Polyubiquitination by HECT E3s and the Determinants of Chain Type Specificity

(2009) H. C. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Nonproteolytic Functions of Ubiquitin in Cell Signaling

(2009) Zhijian J. Chen et al.   MOLECULAR CELL

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

(2009) Simon Bekker-Jensen et al.   NATURE CELL BIOLOGY

Ubiquitination Is Required for Effective Replication of Coxsackievirus B3

(2008) Xiaoning Si et al.   PLoS One