Neuroprotective Effects of Sinomenine on Experimental Autoimmune Encephalomyelitis via Anti-Inflammatory and Nrf2-Dependent Anti-Oxidative Stress Activity

Dipeptide Repeat Pathology in C9orf72-ALS Is Associated with Redox, Mitochondrial and NRF2 Pathway Imbalance

(2022) José Jiménez-Villegas et al.   Antioxidants

The Ins and Outs of Central Nervous System Inflammation—Lessons Learned from Multiple Sclerosis

(2021) Valeria Ramaglia et al.   Annual Review of Immunology

Bilirubin nanomedicine ameliorates the progression of experimental autoimmune encephalomyelitis by modulating dendritic cells

(2021) Tae Woo Kim et al.   JOURNAL OF CONTROLLED RELEASE

Suppression of macrophage migration by down-regulating Src/FAK/P130Cas activation contributed to the anti-inflammatory activity of sinomenine

(2021) Wan-Jiao GAO et al.   PHARMACOLOGICAL RESEARCH

4-Ethylguaiacol modulates neuroinflammation and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis

(2021) Wen-Tsan Weng et al.   Journal of Neuroinflammation

Keap1/Nrf2 Signaling Pathway

(2021) Gerasimos P. Sykiotis   Antioxidants

Methyl acetate arrests Th1 in peripheral immune system and alleviates CNS inflammation in EAE

(2021) Ling Xie et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of lysophosphatidic acid receptor 1–3 deteriorates experimental autoimmune encephalomyelitis by inducing oxidative stress

(2021) Jong Hee Choi et al.   Journal of Neuroinflammation

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway

(2021) Xiangjin Zheng et al.   Acta Pharmaceutica Sinica B

New Insights in the Mechanisms of Impaired Redox Signaling and its Interplay With Inflammation and Immunity in Multiple Sclerosis

(2020) D. MICHALIČKOVÁ et al.   PHYSIOLOGICAL RESEARCH

Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis

(2020) Ping-Chang Kuo et al.   Journal of Neuroinflammation

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

(2020) Andrew S. Mendiola et al.   NATURE IMMUNOLOGY

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

(2020) Dominic S. A. Simpson et al.   Antioxidants

RAM-589.555 favors neuroprotective and anti-inflammatory profile of CNS-resident glial cells in acute relapse EAE affected mice

(2020) Rina Zilkha-Falb et al.   Journal of Neuroinflammation

The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis

(2019) Roberta Brambilla   ACTA NEUROPATHOLOGICA

Microglia suppress the secondary progression of autoimmune encephalomyelitis

(2019) Shogo Tanabe et al.   GLIA

Sinomenine inhibits osteolysis in breast cancer by reducing IL-8/CXCR1 and c-Fos/NFATc1 signaling

(2019) Yueyang Zhang et al.   PHARMACOLOGICAL RESEARCH

Th17 cells, γδ T cells and their interplay in EAE and multiple sclerosis

(2018) Aoife M. McGinley et al.   JOURNAL OF AUTOIMMUNITY

The roles of macrophages and microglia in multiple sclerosis and experimental autoimmune encephalomyelitis

(2018) Fengna Chu et al.   JOURNAL OF NEUROIMMUNOLOGY

Multiple sclerosis

(2018) Alan J Thompson et al.   LANCET

Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

(2018) Alan J Thompson et al.   LANCET NEUROLOGY

Microglial control of astrocytes in response to microbial metabolites

(2018) Veit Rothhammer et al.   NATURE

Canonical and non-canonical mechanisms of Nrf2 activation

(2018) Carlos Alfredo Silva-Islas et al.   PHARMACOLOGICAL RESEARCH

OxInflammation: From Subclinical Condition to Pathological Biomarker

(2018) Giuseppe Valacchi et al.   Frontiers in Physiology

Modulation of Multiple Sclerosis and Its Animal Model Experimental Autoimmune Encephalomyelitis by Food and Gut Microbiota

(2017) Ward J. van den Hoogen et al.   Frontiers in Immunology

Excessive Reactive Oxygen Species and Exotic DNA Lesions as an Exploitable Liability

(2016) Safnas F. AbdulSalam et al.   BIOCHEMISTRY

The natural dual cyclooxygenase and 5-lipoxygenase inhibitor flavocoxid is protective in EAE through effects on Th1/Th17 differentiation and macrophage/microglia activation

(2016) Weimin Kong et al.   BRAIN BEHAVIOR AND IMMUNITY

New Insights into the Role of Oxidative Stress Mechanisms in the Pathophysiology and Treatment of Multiple Sclerosis

(2016) Bożena Adamczyk et al.   Oxidative Medicine and Cellular Longevity

Role of ROS and RNS Sources in Physiological and Pathological Conditions

(2016) Sergio Di Meo et al.   Oxidative Medicine and Cellular Longevity

Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases

(2016) Izaskun Buendia et al.   PHARMACOLOGY & THERAPEUTICS

TNF and ROS Crosstalk in Inflammation

(2016) Heiko Blaser et al.   TRENDS IN CELL BIOLOGY

Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation

(2015) Agata A. Mossakowski et al.   ACTA NEUROPATHOLOGICA

Anti-inflammatory effects of novel sinomenine derivatives

(2015) Zijian Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Celastrol Ameliorates EAE Induction by Suppressing Pathogenic T Cell Responses in the Peripheral and Central Nervous Systems

(2015) Ying Wang et al.   Journal of Neuroimmune Pharmacology

Inhibition of NADPH oxidase activation reduces EAE-induced white matter damage in mice

(2015) Bo Young Choi et al.   Journal of Neuroinflammation

Oxidative Stress in Neurodegenerative Diseases

(2015) Ewa Niedzielska et al.   MOLECULAR NEUROBIOLOGY

18β-glycyrrhetinic acid suppresses experimental autoimmune encephalomyelitis through inhibition of microglia activation and promotion of remyelination

(2015) Jieru Zhou et al.   Scientific Reports

Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance

(2014) Ana I. Rojo et al.   ANTIOXIDANTS & REDOX SIGNALING

Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis

(2014) Roy Y. Kim et al.   JOURNAL OF NEUROIMMUNOLOGY

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

(2014) Lior Mayo et al.   NATURE MEDICINE

Dihydroquercetin (DHQ) Induced HO-1 and NQO1 Expression against Oxidative Stress through the Nrf2-Dependent Antioxidant Pathway

(2013) Lu Liang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mitochondrial dysfunction contributes to neurodegeneration in multiple sclerosis

(2013) Maarten E. Witte et al.   TRENDS IN MOLECULAR MEDICINE

TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis

(2012) Benjamin Schattling et al.   NATURE MEDICINE

Progressive multiple sclerosis: pathology and pathogenesis

(2012) Hans Lassmann et al.   Nature Reviews Neurology

Reactive oxygen species: from health to disease

(2012) K Brieger et al.   SWISS MEDICAL WEEKLY

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

(2011) Cris S Constantinescu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Cellular mechanisms of IL-17-induced blood-brain barrier disruption

(2009) Jula Huppert et al.   FASEB JOURNAL